中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2017, Vol. 46 ›› Issue (11): 976-979.doi: 10.12007/j.issn.0258‐4646.2017.11.004

• 论著 • 上一篇    下一篇

骨形成蛋白2在脑多形性胶质母细胞瘤中的表达及临床意义

张少校1,吴瑛2   

  1. 1 辽宁省盘锦市中心医院VIP病房,辽宁 盘锦 124010;2 中国医科大学附属第一医院全科医学科,沈阳 110001
  • 收稿日期:2017-04-14 出版日期:2017-11-30 发布日期:2017-11-01
  • 通讯作者: 吴瑛 E-mail:1779716865@qq.com
  • 作者简介:张少校(1978-),男,副教授,硕士
  • 基金资助:
    国家自然科学基金(81302023,81201801)

Analysis of the Clinical Significance of Bone Morphogenetic Protein 2 in Glioblastoma Multiforme

ZHANG Shaoxiao1,WU Ying2   

  1. 1 VIP Department,Liaoning Provincial Panjin City Centre Hospital,Panjin 124010,China;2 General Practice Department,The First Hospital,China Medical University,Shenyang 110001,China
  • Received:2017-04-14 Online:2017-11-30 Published:2017-11-01

摘要: 目的 分析人多形性胶质母细胞瘤(GBM)中骨形成蛋白2(BMP2)表达的预后意义和可能的相关信号机制。方法 利用癌症基因组图谱(TCGA)数据库获取GBM标本的RNASeqV2数据,从人类肿瘤相关基因表达汇编(GEO)数据库下载GBM样本数 据集GSE7696的表达谱数据。利用单因素Kaplan-Meier和多因素COX逐步回归法确定BMP2表达与GBM患者预后的关系。利用基 因集富集分析方法预测BMP2相关的基因通路。结果 低表达BMP2是GBM术后患者预后不良的独立因素。BMP2 低表达富集了 干扰素α反应的相关通路。结论 GBM组织中BMP2低表达预示患者预后不良,其作用机制可能是干扰素α反应基因异常。

关键词: 骨形成蛋白2, 多形性胶质母细胞瘤, 癌症基因组图谱, 基因表达汇编

Abstract: Objective To investigate the prognostic significance of bone morphogenetic protein 2(BMP2)expression in glioblastoma multiforme(GBM)and related pathways. Methods RNASeqV2 data and GSE7696 series matrix data were downloaded from The Cancer Genome Atlas(TCGA)and The Gene Expression Omnibus(GEO)database,respectively. The correlation between BMP2 expression and prognosis was evaluated using Kaplan-Meier and multivariate COX analysis. Gene set enrichment analysis(GSEA)was used to predict the functional gene sets and/or pathways modulated by BMP2. Results Decreased expression of BMP2 is an independent predictor of poor prognosis. Furthermore,genes that are upregulated in response to interferon-αproteins were enriched in samples with low BMP2 expres- sion. Conclusion Low expression of BMP2 indicates poor prognosis in GBM patients. Genes that are upregulated in response to interfer- on-α proteins may also be implicated in prognosis.

Key words: bone morphogenetic protein 2, glioblastoma multiforme, the cancer genome atlas, gene expression omnibus

中图分类号: 

  • R739.4
[1] 王硕,李智,郑春雷,曲秀娟,刘静,曲晶磊,车晓芳,刘云鹏. 利用TCGA数据集分析AKT3在胃癌中的表达及临床意义[J]. 中国医科大学学报, 2016, 45(5): 398-401.
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