中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2017, Vol. 46 ›› Issue (11): 1009-1012.doi: 10.12007/j.issn.0258‐4646.2017.11.011

• 论著 • 上一篇    下一篇

急性冠状动脉综合征患者缺血修饰白蛋白水平与冠状动脉病变 程度的相关性研究

紫净1,余陆娇2,张子新3   

  1. 1 民航总医院心内科,北京 100000;2 中国医科大学附属第一医院老年病科,沈阳 110001;3 中国医科大学附属第一医院心内科,沈阳 110001
  • 收稿日期:2017-05-09 出版日期:2017-11-30 发布日期:2017-11-01
  • 通讯作者: 张子新 E-mail:1871521270@qq.com
  • 作者简介:紫净(1990-),女,医师,硕士
  • 基金资助:
    沈阳市科学技术计划(F16-206-9-06)

Correlation between Ischemia-modified Albumin Levels and Coronary Artery Lesions in Patients with Acute Coronary Syndrome

ZI Jing1,YU Lujiao2,ZHANG Zixin3   

  1. 1 Department of Cardiology,Civil Aviation General Hospital,Beijing 100000,China;2 Geriatrics Department,The First Hospital,China Medical University,Shenyang 110001,China;3 Department of Cardiology,The First Hospital,China Medical University,Shenyang 110001,China
  • Received:2017-05-09 Online:2017-11-30 Published:2017-11-01

摘要: 目的 探讨急性冠状动脉综合征(ACS)患者缺血修饰白蛋白(IMA)水平与冠状动脉病变程度的相关性。方法 入选ACS 患者51例。所有患者入院后均进行冠状动脉造影检查及冠状动脉粥样硬化性心脏病规范治疗,收集冠状动脉造影结果并计算 Gensini评分,检测IMA水平。同期选取健康志愿者10例作为对照组。结果 冠状动脉病变组IMA水平均高于对照组(P < 0.05);但 各冠状动脉病变组组间比较IMA水平均无统计学差异。IMA水平与其Gensini评分无相关性;但Gensini评分中度组TIMI血流3级 比例低。结论 ACS患者IMA水平升高,但IMA水平与冠状动脉病变程度无相关性,IMA不能准确反映冠状动脉病变程度,IMA水平升高提示心肌缺血处于不稳定状态。

关键词: 急性冠状动脉综合征, 缺血修饰白蛋白, Gensini评分

Abstract: Objective To evaluate the correlation between ischemia-modified albumin(IMA)levels and severity of coronary artery le- sions in patients with acute coronary syndrome(ACS). Methods This study included 51 in-hospital patients diagnosed as having ACS. All patients had undergone coronary angiography and received the standard treatment for coronary heart disease. Meanwhile,we included 10 healthy volunteers as the control group. Coronary angiography reports were collected,Gensini scores were calculated,and serum IMA levels were measured. Results The IMA levels of patients with ACS were higher than those of the controls(P < 0.05). However,when di- vided by the degree of coronary artery stenosis,number of vessel lesions,and Gensini scores,the IMA levels showed no significant differ- ence between the groups. The IMA levels were not related with the Gensini scores. The moderate group had a low ratio of TIMI flow grade 3. Conclusion Patients with ACS had higher IMA levels. We found no correlation between IMA level and coronary artery lesions. IMA level may not accurately reflect the severity of coronary artery lesions. Increased IMA level may indicate the unstable status of ischemia.

Key words: acute coronary syndrome, ischemia modified albumin, Gensini score

中图分类号: 

  • R543.3
[1] 王迪, 赵玫. 血清胱抑素C、血尿酸水平与冠状动脉粥样硬化性心脏病患者发生急性冠状动脉综合征的相关分析[J]. 中国医科大学学报, 2018, 47(4): 305-307,311.
[2] 胡巍娜,周东晖,王琦,金元哲. 不同年龄段急性冠状动脉综合征患者临床及冠状动脉造影特点分析[J]. 中国医科大学学报, 2017, 46(6): 566-568.
[3] 刘君,雷明明,王妍,金元哲. FKN在急性心肌梗死早期诊断中的作用[J]. 中国医科大学学报, 2015, 44(4): 307-310.
[4] 彭帆,,刘闺男. 老年STEMI伴高尿酸血症患者冠状动脉病变特点分析[J]. 中国医科大学学报, 2015, 44(4): 338-341.
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