中国医科大学学报

中国医科大学学报
  • 中文核心期刊
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (6): 513-518.doi: 10.12007/j.issn.0258‐4646.2018.06.008

• 论著 • 上一篇    下一篇

术前血浆纤维蛋白原和D-二聚体水平与结直肠癌预后的关系

芦婷婷, 王治博   

  1. 中国医科大学附属第一医院肛肠外科, 沈阳 110001
  • 收稿日期:2018-03-26 出版日期:2018-06-30 发布日期:2018-05-29
  • 通讯作者: 芦婷婷 E-mail:sunnylutt@163.com
  • 作者简介:芦婷婷(1982-),女,主治医师,博士.
  • 基金资助:
    辽宁省科学事业公益研究基金(2015005002)

Prognostic Value of Preoperative Fibrinogen and D-dimer Levels in Patients with Colorectal Cancer

LU Tingting, WANG Zhibo   

  1. Department of Anus and Intestine Surgery, The First Hospital, China Medical University, Shenyang 110001, China
  • Received:2018-03-26 Online:2018-06-30 Published:2018-05-29

摘要: 目的 探讨术前血浆纤维蛋白原(Fg)和D-二聚体(D-D)与结直肠癌(CRC)病理生物学行为及预后的关系。方法 选取行根治性手术治疗的CRC患者330例,检测术前血浆Fg和D-D水平,并进行术后随访。结果 CRC患者术前血浆Fg和D-D的阳性率高于CA125、CA153及AFP的阳性率(P<0.05)。术前血浆Fg和D-D均与患者的年龄、肿瘤的部位、分化程度和肿瘤的大小相关(P<0.05)。术前血浆Fg与远处转移相关(P<0.01),术前D-D水平水平还与患者的性别(P=0.017)及饮酒史(P=0.036)相关。多因素生存分析发现,术前血浆D-D水平升高的患者预后较差(校正后HR=1.87,95% CI:1.20~2.92,P<0.01)。结论 术前血浆Fg和D-D与CRC生物学行为及预后密切相关,在临床上有望成为良好的预测肿瘤的标志物。

关键词: 纤维蛋白原, D-二聚体, 结直肠癌, 预后

Abstract: Objective To explore the effect of preoperative plasma fibrinogen (Fg) and D-dimer (D-D) levels in the progression and prognosis of colorectal cancer (CRC). Methods Plasma Fg and D-D levels were measured in 330 CRC patients before undergoing radical surgery. Results The positive rate of plasma Fg and D-D was higher than that of CA125, CA153, and alpha fetoprotein (P<0.05). Preoperative plasma Fg and D-D levels were higher in aged patients, patients with colon cancer, and patients with poorly differentiated or larger tumors (P<0.05). Fg was significantly higher in patients with distant metastasis than in those without distant metastasis (P<0.01). The D-D level was also related to the patient's gender (P=0.017) and drinking history (P=0.036). Survival analysis showed that high plasma D-D levels before surgery were associated with poor survival (adjusted HR=1.87, 95% CI:1.2-2.92, P<0.01). Conclusion Preoperative Fg and D-D levels were associated with the biological behavior and prognosis of CRC and might function as a predictor for the progression and prognosis of CRC.

Key words: fibrinogen, D-dimer, colorectal cancer, prognosis

中图分类号: 

  • R735.34
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