中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (6): 519-521.doi: 10.12007/j.issn.0258‐4646.2018.06.009

• 论著 • 上一篇    下一篇

肿瘤坏死因子α与高血压病合并阻塞型睡眠呼吸暂停综合征的相关性

李雪佳1, 李宇1, 李晓鸥1, 景可晖1, 张茜2, 李飞3   

  1. 1. 沈阳医学院医学应用技术学院2013级康复治疗学专业, 沈阳 110034;
    2. 沈阳医学院医学应用技术学院2014级康复治疗学专业, 沈阳 110034;
    3. 沈阳医学院附属第二医院心内科, 沈阳 110032
  • 收稿日期:2018-03-13 出版日期:2018-06-30 发布日期:2018-05-29
  • 通讯作者: 李飞 E-mail:850438376@qq.com
  • 作者简介:李雪佳(1994-),女,本科在读.
  • 基金资助:
    国家级大学生创新创业训练计划(20160829);辽宁省科学技术计划(2017225077);沈阳医学院科技基金(20162031)

Correlation of Tumor Necrosis Factor α Expression and Hypertension with Obstructive Sleep Apnea Symptoms

LI Xuejia1, LI Yu1, LI Xiaoou1, JING Kehui1, ZHANG Xi2, LI Fei3   

  1. 1. 2013, Department of Rehabilitation Medicine, School of Medical Application Technology, Shenyang Medical College, Shenyang 110034, China;
    2. 2014, Department of Rehabilitation Medicine, School of Medical Application Technology, Shenyang Medical College, Shenyang 110034, China;
    3. Department of Cardiology, The Second Affiliated Hospital of Shenyang Medical College, Shenyang 110032, China
  • Received:2018-03-13 Online:2018-06-30 Published:2018-05-29

摘要: 目的 探讨高血压病合并阻塞型睡眠呼吸暂停综合征(OSAS)患者血清肿瘤坏死因子α(TNF-α)水平的变化。方法 采用ELISA方法测定160例不同程度高血压病合并OSAS患者和500例单纯高血压患者血清TNF-α的变化。结果 轻、中、重度OSAS组患者TNF-α水平显著高于单纯高血压组,重度OSAS组患者TNF-α水平显著高于轻度、中度OSAS组。多重线性回归分析显示,自变量体质量指数的β值为0.172;自变量TNF-α的β值为0.176,说明TNF-α对模型的贡献大于体质量指数。结论 高血压病合并OSAS患者的TNF-α水平越高,OSAS程度越重,TNF-α水平升高可能加重OSAS的严重程度。

关键词: 阻塞型睡眠呼吸暂停综合征, 高血压, 肿瘤坏死因子α

Abstract: Objective To investigate the relationship between the expression of tumor necrosis factor α (TNF-α) and obstructive sleep apnea syndrome (OSAS) with hypertension. Methods The expression of TNF-α in 160 OSAS patients with hypertension and 500 patients with simple hypertension were determined by ELISA. Results The levels of TNF-α in patients with mild, moderate, and severe OSAS were significantly higher than those in the simple hypertension group, and TNF-α levels were significantly higher in the severe OSAS group than in the mild and moderate OSAS groups. Multiple linear regression analysis showed that the value of body mass index (BMI), an independent variable, was 0.172. The value of TNF-α was 0.176, indicating that the contribution of TNF-α to the model is greater than that of BMI. Conclusion Higher levels of TNF-α in OSAS patients with hypertension were positively correlated with the severity of OSAS, potentially because increases in TNF-α levels may aggravate the severity of OSAS.

Key words: obstructive sleep apnea syndrome, hypertension, tumor necrosis factor α

中图分类号: 

  • R544.1
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