中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2016, Vol. 45 ›› Issue (5): 389–393.doi: 10.12007/j.issn.0258-4646.2016.05.002

• 论著 • 上一篇    下一篇

频域光学相干断层扫描测量黄斑区视网膜神经节细胞层厚度

马小力,陈禹橦,刘贤洁,李丹丹,张宏伟,宁宏   

  1. 中国医科大学附属第一医院眼科,沈阳 110001
  • 收稿日期:2016-01-07 出版日期:2016-05-30 发布日期:2016-05-09
  • 通讯作者: 宁宏 E-mail:hongning1978@sina.com
  • 作者简介:马小力(1978 -),女,副教授,博士.
  • 基金资助:
    国家自然科学基金(81200656);辽宁省博士启动基金(20111097);辽宁省科学技术计划(2013225303);辽宁省自然科学基金(2013021029)

Application of Spectral-domain Optical Coherence Tomography in the Measurement of Macular Ganglion Cell Layer

MA Xiaoli,CHEN Yutong,LIU Xianjie,LI Dandan,ZHANG Hongwei,NING Hong   

  1. Department of Ophthalmology,The First Hospital,China Medical University,Shenyang 110001,China
  • Received:2016-01-07 Online:2016-05-30 Published:2016-05-09

摘要: 目的 利用频域光学相干断层扫描(SD-OCT)测量正常人和青光眼患者黄斑区视网膜神经节细胞层(GCL)厚度,并对测量结果进行重复性检验。方法 本研究纳入正常志愿者 24 例(正常对照组)、青光眼患者 21 例(青光眼组),随机选择受试者一侧眼进行测量。利用海德堡 Spectralis SD-OCT 后极部非对称性分析软件对黄斑区视网膜进行扫描,以早期糖尿病视网膜病变治疗研究标准对黄斑区进行分区,分析比较正常对照组和青光眼组黄斑各分区视网膜 GCL 厚度,并计算组内标准差(Sw)、变异系数(CV)和组内相关系数(ICC)。结果 正常对照组黄斑中央区 GCL 厚度为(12.58±2.69)μm,内环平均 GCL 厚度为(48.87±3.81)μm,外环平均 GCL 厚度为(37.28±1.75)μm,呈开口向颞侧的“马蹄形”分布;青光眼组黄斑中央区 GCL 厚度为(9.57±2.06)μm,内环平均 GCL 厚度为(34.70±9.67)μm,外环平均 GCL 厚度为(28.20±5.51)μm,各区视网膜 GCL 均较正常对照组明显变薄。正常对照组各分区 GCL 厚度的 Sw 为 0.46~0.87 μm,CV 为 0.67%~3.71%,ICC 为 0.904~0.977;青光眼组 Sw 为 0.53~1.65 μm,CV 为 1.18%~5.75%,ICC 为 0.833~0.993,2 组均具有良好的重复性。结论 利用 Spectralis SD-OCT 测量视网膜黄斑区 GCL 厚度在正常人和青光眼患者中均具有良好的可重复性,可用于临床青光眼的检查和长期随访。

关键词: 视网膜神经节细胞层, 频域光学相干断层扫描, 青光眼

Abstract: Objective To evaluate the reproducibility of macular ganglion cell layer(GCL)measurements with high-resolution spectral domainoptical coherence tomography(SD-OCT)in both normal people and glaucoma patients. Methods In this study,24 normal subjects and 21 glaucoma patients were prospectively included. Macular GCL thickness in 9 areas defined by Early Treatment Diabetic Retinopathy Study was measured with Spectralis SD-OCT applying posterior pole asymmetry analysis pattern. Within-subject standard deviation(Sw),coefficient of variation(CV) and intraclass correlation coefficient(ICC)in normal subjects and glaucoma patients were assessed. ResultsIn normal subjects,the GCL thickness in macular central area was 12.58±2.69 μm,the average GCL thickness in inner ring area was 48.87±3.81 μm,the average GCL thickness in outer ring area was 37.28±1.75 μm,and the GCL thickness mapping in normal subjects was horseshoe-shaped with opening to temporal. In glaucoma patients,the GCL thickness in central area was 9.57±2.06 μm,the average GCL thickness in inner ring area was 34.70±9.67 μm,the average GCL thickness in outer ring area was 28.20±5.51 μm,and the GCL thickness in every macular area in glaucoma eyes was thinner than that in normal eyes(P < 0.001). For measurements of GCL thickness in normal subjects,Sw was 0.46 to 0.87 μm,CV was 0.67% to 3.71%,and ICC was 0.904 to 0.977. For measurements of GCL thickness in glaucoma patients,Sw was 0.53 to 1.65 μm,CV was 1.18% to 5.75%,and ICC was 0.833 to 0.993. Conclusion Spectralis SD-OCT had an excellent reproducibility for measurements of GCL thickness in both normal people and glaucoma patients, which is a reliable technique for evaluating longitudinal change and follow-up in glaucoma.

Key words: ganglion cell layer, spectral domain-optical coherence tomography, glaucoma

中图分类号: 

  • R775
[1] 刘贤洁, 陈禹橦, 刘美丹, 马小力. 应用频域光学相干断层扫描分析高度近视患者黄斑区外层视网膜厚度[J]. 中国医科大学学报, 2018, 47(5): 390-393.
[2] 黄婷, 秦宇, 曲勃. AS-OCT、Lenstar、UBM测量中央角膜厚度的结果比较[J]. 中国医科大学学报, 2018, 47(2): 123-127.
[3] 马小力,陈禹橦,刘贤洁,李丹丹,张宏伟,宁宏. 频域光学相干断层扫描测量青光眼视网膜神经纤维层厚度的可重复性研究[J]. 中国医科大学学报, 2016, 45(3): 197-200.
[4] 马小力,刘贤洁,陈禹橦,李丹丹,张宏伟,华瑞. 利用频域光学相干断层扫描测量青光眼视盘旁萎缩区[J]. 中国医科大学学报, 2015, 44(12): 1057-1060.
[5] 尚琢, 彭程, 赵芳坤, 刘野, 赵江月, 张劲松. 心理干预对青光眼患者生活质量的影响[J]. 中国医科大学学报, 2012, 41(2): 190-190.
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