中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2016, Vol. 45 ›› Issue (5): 406–408.doi: 10.12007/j.issn.0258-4646.2016.05.006

• 论著 • 上一篇    下一篇

重症监护病房老年患者鲍曼不动杆菌感染的临床特点及药敏分析

吴宝刚,万小旭,刘丹,白雪,王佳贺   

  1. 中国医科大学附属盛京医院老年病科,沈阳 110004
  • 收稿日期:2015-12-06 出版日期:2016-05-30 发布日期:2016-05-09
  • 作者简介:吴宝刚(1976 -),男,讲师,博士.
  • 基金资助:
    国家自然科学基金(81101224)

Clinical Characteristics of Acinetobacter baumannii Infections in Elderly Patients in Intensive Care Unit and Analysis of Drug Susceptibility

WU Baogang,WAN Xiaoxu,LIU Dan,BAI Xue,WANG Jiahe   

  1. Department of Geriatrics,Shengjing Hospital,China Medical University,Shenyang 110004,China
  • Received:2015-12-06 Online:2016-05-30 Published:2016-05-09

摘要: 目的 探讨重症监护病房(ICU)老年患者鲍曼不动杆菌感染的临床分布特点及药敏分析。方法 选取 2013 年 1 月至2015 年 12 月本院 ICU 住院鲍曼不动杆菌感染老年患者 220 例,送检的各种临床标本中分离培养细菌,使用 Bio-Merieux 公司生产的 VITEK-32 型全自动微生物鉴定分析仪进行细菌鉴定。应用 WHONET5.6 软件进行数据处理分析。结果 共分离出鲍曼不动杆菌 259 株。其中痰标本分离出 185 株(71.43%);引流液分离出 34 株(13.13%);血标本中分离出 16 株(6.18%);其他标本分离出 24 株(9.26%)。鲍曼不动杆菌感染的老年患者中男多于女,感染患者及分离出的菌株数逐年增加。鲍曼不动杆菌对抗菌药物呈现广泛耐药性,但对替加环素的敏感性最高(70.13%~80.85%),耐药性最低(0~23.38%)。结论 鲍曼不动杆菌对不同抗菌药物的药敏性不同,临床上抗感染治疗应以本地区分离菌株的体外抗菌药物敏感性试验结果为依据,选择敏感的抗菌药物进行治疗。

关键词: 鲍曼不动杆菌, 老年患者, 药敏

Abstract: Objective To understand the clinical characteristics of Acinetobacter baumannii infections in elderly patients in intensive care unit(ICU) and investigate its drug susceptibility. Methods Bacterial identification was carried out by VITEK - 32 automatic micro - analyzer(Bio-Merieux Company of French). Data processing was performed with WHONET5.6 software. ResultsTotally 259 strains of Acinetobacter baumannii were isolated from 220 infected elderly patients. The detection rate of Acinetobacter baumannii was 71.43%(185 strains),13.13%(34 strains),6.18%(16 strains) and 9.26%(24 strains) from sputum, drainage fluid, blood and other specimens, respectively . Drug resistance of Acinetobacter baumannii to antibiotics was relatively high. Resistance to tigecycline of Acinetobacter baumannii strains was the lowest(0%-23.38%)while the susceptibility was the highest(70.13%-80.85%)in all kinds of antibiotics in this study. Conclusion Acinetobacter baumannii varied in drug resistance to different antibiotics. It is necessary to choose susceptible antibiotics for clinical anti-infection treatment on the basis of in-vitro antibiotics susceptibility testing for isolated strains from local regions.

Key words: Acinetobacter baumannii, elderly patients, drug susceptibility

中图分类号: 

  • R378
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