中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2016, Vol. 45 ›› Issue (5): 434–437.doi: 10.12007/j.issn.0258-4646.2016.05.013

• 论著 • 上一篇    下一篇

吉兰-巴雷综合征患者神经电生理特点及其与机械通气、远期预后的相关性分析

朱皓月 1,李妍 1,金娟 1,赵珊珊 1,曲慧玲 2,赵传胜 1   

  1. 1 中国医科大学附属第一医院神经内科,沈阳 110001; 2 辽宁省人民医院神经内科,沈阳 110016
  • 收稿日期:2015-10-20 出版日期:2016-05-30 发布日期:2016-05-09
  • 通讯作者: 赵传胜 E-mail:cszhao@mail.cmu.edu.cn
  • 作者简介:朱皓月(1990 -),女,硕士研究生.
  • 基金资助:
    辽宁省自然科学基金(201202276)

Correlation Analysis between Electrophysiological Features and Mechanical Ventilation and Long-term Outcome in Patients with Guillain-Barré Syndrome

ZHU Haoyue 1,LI Yan 1,JIN Juan 1,ZHAO Shanshan 1,QU Huiling 2,ZHAO Chuansheng 1   

  1. 1 Department of Neurology,The First Hospital,China Medical University,Shenyang 110001,China; 2 Department of Neurology,People′s Hospital of Liaoning Province,Shenyang 110016,China
  • Received:2015-10-20 Online:2016-05-30 Published:2016-05-09

摘要: 目的 回顾性研究吉兰-巴雷综合征(GBS)患者神经电生理特点及其与机械通气、远期预后的相关性。方法 收集2013 年 4 月至 2015 年 9 月就诊于中国医科大学附属第一医院神经内科的 38 例 GBS 患者的神经电生理数据及临床资料,根据病程中是否接受机械通气分为上机组和未上机组;根据 Hadden 等的分型标准分为急性炎性脱髓鞘性多发神经根神经病(AIDP)、急性运动轴索性神经病(AMAN)和未分类组,分别比较组间神经电生理及临床特点。结果 上机组腓总神经近端/远端复合肌肉动作电位波幅(p/d CMAP,48.7±15.3)比值明显低于非上机组(80.8±24.0,P = 0.005),AIDP 中接受机械通气的比例(46%)明显高于 AMAN(0%)及未分类组(9%,P = 0.027),AMAN 的远期预后评分(4.3±1.3)明显低于 AIDP(2.5±0.9,P = 0.028)。结论 神经电生理检查对机械通气及远期预后有预示作用,腓总神经 p/dCMAP 比值下降可以预测机械通气;AIDP 患者更易发生呼吸衰竭,与 AMAN 患者相比预后不良。

关键词: 吉兰-巴雷综合征, 神经电生理, 机械通气, 远期预后

Abstract: Objective To study the correlation between the electrophysiological features and mechanical ventilation and long-term outcome in Guillain-Barré syndrome(GBS)patients. Methods Electrophysiological and clinical data were retrospectively collected, and compared between ventilated and not ventilated patients,as well as among each subtype of GBS. ResultsTotally 38 GBS patients were included in the study, among which 12(32%)were ventilated. The p/d CMAP ratio of the common peroneal nerve was significantly lower in ventilated group compared to not ventilated group(48.7±15.3 vs 80.8±24.0,P = 0.005). AIDP was the most common subtype in ventilated patients compared with AMAN and undetermined (46% vs 0% and 9%,P = 0.027). The long-term outcome score of AMAN was significantly lower than AIDP(4.3±1.3 vs 2.5±0.9,P = 0.028). Conclusion Electrophysiological testing was predictive for mechanical ventilation and long-term outcome: low p/d CMAP ratio of the common peroneal nerve was helpful for predicting mechanical ventilation, AIDP was prone to develop respiratory failure and had a worse outcome compared to AMAN.

Key words: Guillain-Barré syndrome, electrophysiology, mechanical ventilation, long-term outcome

中图分类号: 

  • R745.4
[1] 张晓雨. 机械振动排痰机在重症肺炎患儿机械通气气道护理中的应用[J]. 中国医科大学学报, 2018, 47(2): 185-187.
[2] 吴鹏飞,王明昊,崔晓,王维,赵丹,刘济源,马跃,王英奇,仇波,陶钧,王运杰. 延髓海绵状血管瘤的显微外科手术治疗[J]. 中国医科大学学报, 2017, 46(6): 505-509.
[3] 赵璠,贺琳晰. 高频机械通气治疗急性呼吸窘迫综合征患儿的护理体会[J]. 中国医科大学学报, 2016, 45(2): 167-168.
[4] 刘晓伟,靳妍,马涛,裴培,刘志. 吸痰对患者呼吸力学和气体交换的影响[J]. 中国医科大学学报, 2013, 42(9): 825-829.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!

中国医科大学学报版权所有©2018

未经允许,严禁擅自转载本站图文资料

地址:中国 沈阳市沈北新区蒲河路77号 110122

辽ICP备05014850

JOURNAL OF CHINA MEDICAL UNIVERSITY

ADDRESS: NO.77 PUHE ROAD

SHENYANG NORTH NEW AREA, SHENYANG

LIAONING PROVINCE, P.R. CHINA