中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2016, Vol. 45 ›› Issue (6): 546–549.doi: 10.12007/j.issn.0258-4646.2016.06.017

• 论著 • 上一篇    下一篇

124 例干燥综合征合并肺间质病变患者的临床分析

阙雪莹,肖卫国   

  1. 中国医科大学附属第一医院风湿免疫科,沈阳 110001
  • 收稿日期:2015-10-25 出版日期:2016-06-28 发布日期:2016-05-30
  • 通讯作者: 肖卫国 E-mail:sunnyquexueying@163.com
  • 作者简介:阙雪莹(1986 -),女,医师,硕士.

Clinical Analysis of 124 Patients with Sj?gren Syndrome Associated with Interstitial Lung Disease

QUE Xueying,XIAO Weiguo   

  1. Department of Rheumatology and Immunology,The First Hospital,China Medical University,Shenyang 110001,China
  • Received:2015-10-25 Online:2016-06-28 Published:2016-05-30

摘要: 目的 探讨干燥综合征(SS)合并肺间质病变(ILD)患者的临床特点。方法 回顾性分析 124 例 SS 患者的临床资料,其中 ILD 组 51 例,无 ILD 组 73 例,对其临床表现及实验室检验指标等进行分析。结果 SS 患者 ILD 的发生率为 41.13%,ILD 组患者的平均年龄高于无 ILD 组。ILD 组雷诺现象、呼吸道症状、发热、血清γ-球蛋白升高、免疫球蛋白升高、炎性指标升高的发生率均高于无 ILD 组(P < 0.05)。结论 SS 患者中,高龄,出现发热、呼吸道症状或雷诺现象,γ-球蛋白、免疫球蛋白升高,C 反应蛋白、红细胞沉降率升高均可提示 ILD 的可能,为 ILD 的危险因素。

关键词: 干燥综合征, 肺间质病变

Abstract: Objective To investigate the clinical characteristics of Sj?gren syndrome(SS)patients combined with interstitial lung disease(ILD). Methods The medical records of clinical manifestation and laboratory tests from 124 SS patients were retrospective analyzed,of which 51 patients were diagnosed with ILD and 73 patients without ILD. Results The incidence of ILD in SS patients was 41.13%. The average age of onset was later in SS with ILD than that in SS without ILD. The Raynaud′s phenomenon,fever and respiratory clinical manifestations were more common in SS with ILD than that in SS without ILD.Compared with patients without ILD,patients with ILD had significantly higher level of γ-globulin,immunoglobulin and inflammatory markers(P < 0.05). Conclusion The advanced age,Raynaud′s phenomenon,fever or respiratory clinical manifestations,higher level of γ-globulin,immunoglobulin,C-reactive protein and erythrocyte sedimentation rate in SS patients may suggest complication with ILD. Those were the risk factors for ILD.

Key words: Sj?gren syndrome, interstitial lung disease

中图分类号: 

  • R593.2
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[3] 杨晓晴,赵文娟,艾汐汐,肖卫国. 男性及女性干燥综合征患者的临床及血清学特点对比分析[J]. 中国医科大学学报, 2014, 43(11): 1028-1032.
[4] 刘儒曦,杨娉婷,李裔烁,肖卫国. 自身免疫性肝病合并干燥综合征患者肝功能的研究[J]. 中国医科大学学报, 2012, 41(12): 1146-1147.
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