中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2016, Vol. 45 ›› Issue (8): 733–738.doi: 10.12007/j.issn.0258-4646.2016.08.015

• 论著 • 上一篇    下一篇

幽门螺杆菌感染与自身免疫性甲状腺病关系的 meta 分析

岳春艳 1,杨彩哲 2,杨殷 2,刘朝阳 2   

  1. 1 河北北方学院研究生院内科学,河北 张家口 075000;2 空军总医院内分泌科,北京 100142
  • 收稿日期:2015-12-09 出版日期:2016-08-20 发布日期:2016-07-23
  • 通讯作者: 杨彩哲 E-mail:yangcaizhe2008@163.com
  • 作者简介:岳春艳(1984 -),女,住院医师,硕士 .

Meta Analysis of Relationship between Helicobacter pylori Infection and Autoimmune Thyroid Diseases

YUE Chunyan1,YANG Caizhe2,YANG Yin2,LIU Chaoyang2   

  1. 1 Hebei North University Graduate School,Internal medicine,Zhangjiakou 075000,China;2 Department of Endocrinology,General Hospital of Air Force,Beijing 100142,China
  • Received:2015-12-09 Online:2016-08-20 Published:2016-07-23

摘要: 目的 通过 meta 分析探讨幽门螺杆菌(H. pylori)感染与自身免疫性甲状腺病(ATDs)的相关性。方法 检索国内外各大型数据库自建库至 2015 年 10 月发表的有关 H. pylori 感染与 ATDs 关系的文献。由 2 名研究人员独立提取资料并评价纳入文 献质量,采用 Revman 5.3 软件分析,计算合并 OR 值及其 95%CI。结果 共 12 篇文献纳入研究,总样本量 1 615 例,病例组 918 例,对照组 697 例。与对照组比较,H. pylori 感染增加 ATDs 发生风险[OR =1.86,95% CI 为(1.18,2.94)];H. pylori 细胞毒素相关 蛋白(H. Pylori-CagA)阳性菌株感染增加 ATDs 发生风险[OR =2.66,95% CI 为(1.61,4.41);H. pylori 感染与格雷夫斯(Graves)病[OR =3.37,95% CI 为(1.90,5.97)]和桥本甲状腺炎[OR =1.83,95% CI 为(1.22,2.76)的发生均有关。发表偏倚和敏感性分析证 实上述 meta 分析结果是稳定和可靠的。结论 H. Pylori 感染与 ATDs 的发生有关。

关键词: 幽门螺杆菌, 自身免疫性甲状腺病, meta 分析

Abstract: Objective To investigate the association between Helicobacter pylori(H. pylori) infection and Autoimmune thyroid diseases(ATDs). Methods The literatures on the association of H. pylori with ATDs were retrieved by searching databases from the inception of each database to October 2015. Data extraction and quality assessment were completed by two authors. Meta analysis was performed using RevMan 5.3 software,calculating the odds ratio and 95% confidence interval. Results Twelve papers were included for the meta-analysis. The total sample size was 1 615,with 918 cases and 697 controls,respectively. Compared with the controls,H.pylori infection significantly increased the risk of auto- immune thyroid diseases development with a pooled of[OR =1.86,95% C(I 1.18,2.94)]. H. Pylori-CagA infection significantly increased the risk of autoimmune thyroid diseases development with a pooled of[OR =2.66,95% CI(1.61,4.41)]. H. pylori infection is associated with Graves dis- ease[OR =3.37,95% C(I 1.90-5.97)]and Hashimoto′s thyroiditis[OR =1.83,95% C(I 1.22,2.76)]. The results of publication bias and sensitivi- ty analysis confirmed the reliability and stability of this meta analysis. Conclusion H. pylori infection may be associated with an increased risk of developing the autoimmune thyroid diseases.

Key words: Helicobacter pylori, autoimmune thyroid diseases, meta analysis

中图分类号: 

  • R581.9
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