中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2016, Vol. 45 ›› Issue (9): 809–812.doi: 10.12007/j.issn.0258-4646.2016.09.010

• 论著 • 上一篇    下一篇

Rho 激酶对急性冠脉综合征患者左心功能的影响

李文华,何国平,李勇   

  1. 常州市武进人民医院心内科,江苏 常州 213000
  • 收稿日期:2016-02-23 出版日期:2016-09-28 发布日期:2016-08-29
  • 作者简介:李文华(1979 -),男,副主任医师,硕士 .
  • 基金资助:
    常州市武进发展科技基金(WS201320)

Influence of Rho-kinase on Left Heart Function in Patients with Acute Coronary Syndrome

LI Wenhua,HE Guoping,LI Yong   

  1. Department of Cardiology,Changzhou Wujin People′s Hospital,Changzhou 213000,China
  • Received:2016-02-23 Online:2016-09-28 Published:2016-08-29

摘要: 目的 探讨 Rho 激酶活性对急性冠脉综合征(ACS)患者左心功能的影响。方法 入选 2013 年 3 月至 2014 年 12 月间我科收治的 ACS 患者 180 例,根据 Rho 激酶活性的高低分为高活性组和低活性组,随访 12 个月,对比观察 2 组入院时、治疗结束出 院后 3 和 12 个月 Rho 激酶活性、氨基末端脑钠肽前体(NT-proBNP)水平和左心功能指标的差异,评价 Rho 激酶对 ACS 患者左心 功能的影响以及对治疗结束后 12 个月 ACS 患者左心功能的预测价值。结果 随访 12 个月时,高活性组 Rho 激酶和 NT-proBNP 水平明显高于低活性组(P < 0.05)。高活性组左房内径、左室舒张末期内径值明显高于低活性组(P < 0.05),左室射血分数和心 脏指数明显低于低活性组(P < 0.05)。相关性分析显示,Rho 激酶与 NT-proBNP 呈正相关(r = 0.685,P < 0.01)。logistic 回归分析 显示,Rho 激酶活性是影响 ACS 患者治疗结束后 12 个月左心功能的独立预测因子(P < 0.05)。结论 Rho 激酶与 NT-proBNP 呈 正相关,可作为评价 ACS 患者左心功能的一项可靠指标。Rho 激酶是 ACS 患者治疗结束后 12 个月左心功能的独立预测因子。

关键词: Rho 激酶, 急性冠脉综合征, 氨基末端脑钠肽前体, 心脏指数

Abstract: Objective To explore the influence of Rho-kinase activity on left heart function in patients with acute coronary syndrome(ACS). Methods A total of 180 patients with ACS,according to the level of Rho-kinase activity,were enrolled for the study and divided into highly reactive group and lowly reactive group. The changes of Rho-kinase activity,N-terminal pro-B-type natriuretic peptide(NT-proBNP)and left heart function were detected in each group. The influence of Rho-kinase activity on left heart function within 12 months was analyzed. Results The Rho-kinase activity and NT-proBNP were significantly higher in highly reactive group compared with lowly reactive group(P < 0.05). At 12-month follow-up,the measurements of left ventricular end diastolic diameter and left atrial diameter in highly activity group were significantly larger than those in lowly activity group(P < 0.05). The left ventricular ejection fraction and cardiac index were significantly smaller than those in lowly activity group(P < 0.05). There was positive correlation between Rho-kinase activity and NT-proBNP. The logistic regression analysis displayed that Rho-kinase activity is an independent risk factor which may predict the left heart function of ACS patients within 12 months after admission. Conclusion Rho-kinase could be a reliable parameter for evaluating the severity of left heart function in ACS patients,which is also an independent predictive biomarker of left heart function in ACS patients within 12 months after admission.

Key words: Rho-kinase, acute coronary syndrome, N-terminal pro-B-type natriuretic peptide, cardiac index

中图分类号: 

  • R541.4
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