中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2016, Vol. 45 ›› Issue (9): 835–837.doi: 10.12007/j.issn.0258-4646.2016.09.015

• 论著 • 上一篇    下一篇

重组人促红素在人工膝关节表面置换术后红细胞动员中的作用

边磊,白希壮,王立国,王军,杜张珍,李旭   

  1. 中国医科大学附属第一医院运动医学/关节外科,沈阳 110001
  • 收稿日期:2015-05-21 出版日期:2016-09-28 发布日期:2016-08-29
  • 通讯作者: 李旭 E-mail:likyoku@aliyun.com
  • 作者简介:边磊(1990 -),男,硕士研究生 .

Effects of Recombinant Human Erythropoietin in the Red Blood Cell Mobilization after Total Knee Arthroplasty

BIAN Lei,BAI Xizhuang,WANG Liguo,WANG Jun,DU Zhangzhen,LI Xu   

  1. Department of Sports Medicine/Joint Surgery,The First Hospital,China Medical University,Shenyang 110001,China
  • Received:2015-05-21 Online:2016-09-28 Published:2016-08-29

摘要: 目的 探讨重组人促红素(rhEPO)在人工膝关节表面置换术(TKA)后红细胞动员中的作用,并简单评价其安全性。方法 随机将 36 例行初次单侧 TKA 的膝关节骨性关节炎患者分为实验组与对照组,每组 18 例。实验组术后开始给予 rhEPO,对照组不给予 rhEPO,其他同实验组。对 2 组患者术后血常规检测结果及血压情况进行分析。结果 2 组血红蛋白值于术后 7 d开始出现差异,而血小板结果及血压值无明显差异。结论 TKA 术后应用 rhEPO 能够较早地纠正术后贫血,且具有一定的安全性。

关键词: 重组人促红素, 人工膝关节表面置换术, 贫血

Abstract: Objective To investigate the effects of recombinant human erythropoietin(rhEPO)in the red blood cell mobilization after total knee arthroplasty(TKA)and evaluate its safety. Methods A total of 36 cases of knee osteoarthritis were divided into experimental group and control group randomly,with 18 cases in each group. The patients received primary unilateral TKA,then the patients in the experimental group were given rhEPO after surgery,and control group was not. The postoperative blood routine tests were performed for both groups and blood pressure were analyzed. Results Among the two groups,Hb value differences began to appear on the 7th day after surgery,and no significant difference was found on the PLT or the blood pressure value. Conclusion The application of rhEPO is helpful for early postoperative anemia correction after TKA,and has a certain security.

Key words: recombinant human erythropoietin, total knee arthroplasty, anemia

中图分类号: 

  • R684.3
[1] 娄晔,于艺冰,詹立辉,邓娜,李巍巍,樊华. 骨髓增生异常综合征中FANCF蛋白及甲基化研究[J]. 中国医科大学学报, 2013, 42(7): 595-598.
[2] 蔡大利,高峰,高然,李艳. 异基因外周血造血干细胞联合骨髓移植治疗重型再生障碍性贫血:4例报告[J]. 中国医科大学学报, 2013, 42(4): 379-382.
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