中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2017, Vol. 46 ›› Issue (1): 55-58.doi: 10.12007/j.issn.0258-4646.2017.01.012

• 论著 • 上一篇    下一篇

原发性肾病综合征患儿血尿酸水平及其影响因素分析

黄晓芳 1,2,毛建华 1,沈辉君 1,傅海东 1,王晶晶 1   

  1. 1浙江大学医学院附属儿童医院肾内科,杭州 310001;2杭州市中医院儿科,杭州 310001
  • 收稿日期:2016-03-28 出版日期:2017-01-28 发布日期:2017-01-10
  • 通讯作者: 毛建华 E-mail:maojh88@gmail.com
  • 作者简介:黄晓芳(1981 -),女,主治医师,本科 .

Serum Uric Acid Level and Its Influencing Factors in Children with Primary Nephrotic Syndrome

HUANG Xiaofang1,2,MAO Jianhua1,SHEN Huijun1,FU Haidong1,WANG Jingjing1   

  1. 1Department of Nephrology,The Children’s Hospital,Zhejiang University School of Medicine,Hangzhou 310001,China;2 Department of Paediatrics,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310001,China
  • Received:2016-03-28 Online:2017-01-28 Published:2017-01-10

摘要: 目的 分析原发性肾病综合征(PNS)患儿血尿酸水平与各尿酸排泄指标的相关性,探讨 PNS 患儿高尿酸血症患病的可 能机制。方法 回顾性分析 74 例 PNS 患儿的临床资料,比较合并高尿酸血症组(HUA 组)与尿酸正常组(NUA 组)患儿年龄、血 尿酸、肌酐、尿素、胱抑素 C、血甘油三酯、血胆固醇、血白蛋白、肌酐清除率、24 h 尿尿酸、血尿酸/血肌酐、尿酸清除率、尿酸排泄 分数等指标的差异,并对尿酸排泄指标进行相关性分析。结果 HUA 组血白蛋白 、尿酸排泄分数较 NUA 组低(P 分别为0.034),而 HUA 组血胱抑素 C、血尿酸/血肌酐比值较 NUA 组高(P 分别为 0.038、0.001);PNS 患儿尿酸排泄分数与血尿酸水平呈 负相关(r = -0.43,P = 0.016),血尿酸/血肌酐比值与血尿酸呈正相关(r = 0.486,P = 0.001)。结论 PNS 可引起血尿酸生成增多及排泄减少;血尿酸水平与肾小管功能密切相关。

关键词: 肾病综合征, 尿酸, 尿酸排泄分数, 儿童

Abstract: Objective To explore the correlation between serum uric acid levels and uric acid excretion indexes in children with primary nephrot ic syndrome(PNS),and to reveal the prevalence of hyperuricemia and its possible causes in PNS. Methods The clinical data in 74 cases of pediatric PNS were retrospectively analyzed. These patients were grouped as hyperuric acid(HUA)or non-hyperuric acid(NUA),and their clinical features and laboratory findings were compared between two groups,including age,serum uric acid,serum creatinine,urea,cystatin C,triglyceride,cholesterol,albumin,creatinine clearance rate,24 hours urine uric acid,serum uric acid / serum creatinine,uric acid clearance,and the fractional excretion of uric acid and other indicators of differences. In addition,a correlation analysis was carried out for the excretion of uric acid index. Results Several factors were lower in HUA group than that of NUA group,such as the serum albumin and fractional excretion of uric acid(P1 =0.034,P2 = 0.025);while the serum cystatin C and serum uric acid /serum creatinine ratio(P1 = 0.038,P2 = 0.001)was higher in HUA group.The uric acid excretion was negatively correlated with serum uric acid levels in all 74 children with PNS(r = -0.43,P = 0.016),and the serum uric acid / creatinine ratio was positively correlated with serum uric acid(r = 0.486,P = 0.001). Conclusion Both the increase of blood uric acid production and excretion reduction were observed in children with PNS,and the serum uric acid levels and renal tubular function is closely related.

Key words: primary nephrotic syndrome, uric acid, uric acid excretion fraction, children

中图分类号: 

  • R725
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