中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2017, Vol. 46 ›› Issue (1): 68-71.doi: 10.12007/j.issn.0258-4646.2017.01.015

• 论著 • 上一篇    下一篇

2型糖尿病患者血清维生素D 水平及其影响因素

毛琳,李莉   

  1. 中国医科大学附属盛京医院第一内分泌科,沈阳 110004
  • 收稿日期:2016-05-16 出版日期:2017-01-28 发布日期:2017-01-10
  • 通讯作者: 李莉 E-mail:lilysy90@hotmail.com
  • 作者简介:毛琳(1989 -),女,医师,硕士研究生 .

Expression Levels and Its Influencing Risk Factors of Serum Vitamin D in Type 2 Diabetes Patients

MAO Lin,LI Li   

  1. Department of Endocrinology and Metabolism,Institute of Endorinology,Shengjing Hospital,China Medical University,Shenyang 110004,China
  • Received:2016-05-16 Online:2017-01-28 Published:2017-01-10

摘要: 目的 评估 2 型糖尿病患者血清 25-羟维生素 D3 [ 25(OH)D3]水平与代谢的关系。方法 选择 2014 年 6 月至 2015 年 6 月 于我院内分泌科住院的辽宁省地区 2 型糖尿病患者 254 例,根据血清 25(OH)D3 测定时间将所有患者分为 A 组(1~5 月和 12 月) 和 B 组(6~11 月),比较 2 组 25(OH)D3、糖化血红蛋白、空腹血糖等代谢指标,另外根据血清 25(OH)D3 水平将 A、B 2 组各分为 4 个亚组:A1 组和 B1 组,25(OH)D3≥30 ng/mL;A2 组和 B2 组,25(OH)D3 为 20~<30 ng/mL;A3 组和 B3 组,25(OH)D3 为 10~<20 ng/mL;A4 组和 B4 组,25(OH)D3<10 ng/mL。比较各亚组相关代谢指标。结果 B 组血清 25(OH)D3 水平高于 A 组(P < 0.001)。 A3 组糖化血红蛋白低于 A4 组(P = 0.043)。A 组和 B 组以及各个亚组间血钙差异无统计学意义(P > 0.05)。结论 辽宁省地区 的 2 型糖尿病患者维生素 D 水平普遍较低,冬春季较夏秋季更显著。辽宁省地区 2 型糖尿病患者需要补充维生素 D,增加户外 运动。2 型糖尿病患者维生素 D 缺乏与血糖水平有关。血清钙不能作为评估维生素 D 的指标。

关键词: 2 型糖尿病, 维生素 D, 25-羟维生素 D3

Abstract: Objective To evaluate the serum 25-hydroxyvitamin D3 [ 25(OH)D3]level in type 2 diabetes mellitus patients and explore its relationship with energy metabolism. Methods A total of 254 type 2 diabetes mellitus patients from Liaoning Province admitted to the Endocrinology Department of our hospital from June 2014 to June 2015 were enrolled into this study. The serum 25(OH)D3 levels of the patients were measured, and the subjects were divided into different groups as follow:the measurement time of 25(OH)D3 from January to May and December was group A,June to November was group B. The parameters of 25(OH)D3,hemoglobin A1C,fasting plasma glucose and other metabolic indicators were compared between the two groups. In addition,the two groups were divided into four subgroups abased on the level of serum 25(OH)D3:≥30 ng/ mL in subgroups A1 and B1,20-<30 ng/mL in subgroups A2 and B2,10-<20 ng/mL in subgroups A3 and B3,and <10 ng/mL in subgroups A4 and B4. The metabolic indexes of different subgroups were compared. Results Serum 25(OH)D3 in group B was higher than that in group A(P < 0.001). In subgroup A3,hemoglobin A1c was lower than that in subgroup A4(P = 0.043). Groups A and B and each subgroup had no statistical significance in serum calcium(P > 0.05). Conclusion The level of serum vitamin D has a prevalently decrease in type 2 diabetes mellitus in Liaoning Province,especially in winter and spring. These patients would benefit from supplement vitamin D and outdoor exercise. Vitamin D deficiency in patients with type 2 diabetes is associated with blood sugar. Serum calcium can not be used as an indicator of vitamin D.

Key words: type 2 diabetes mellitus, vitamin D, 25-hydroxyvitamin D3

中图分类号: 

  • R587.1
[1] 陈建康 ,严瑜 ,潘晓莉 ,张泓 ,林帆 ,朱鹏立 ,柯俊. 膜联蛋白 A1 对糖尿病大鼠心功能及炎症反应的影响[J]. 中国医科大学学报, 2017, 46(6): 532-535.
[2] 王平,单忠艳,姜雅秋. 217 例 2 型糖尿病住院患者血糖波动的影响因素[J]. 中国医科大学学报, 2017, 46(3): 244-247.
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