中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2017, Vol. 46 ›› Issue (4): 342-344.doi: 10.12007/j.issn.0258-4646.2017.04.014

• 论著 • 上一篇    下一篇

甘草对高脂血症大鼠模型洛伐他汀药代动力学的影响

张瑛瑛,李季泓   

  1. 辽宁中医药大学附属医院药学部,沈阳 110032
  • 收稿日期:2016-12-21 出版日期:2017-04-30 发布日期:2017-04-19
  • 作者简介:张瑛瑛(1970 -),女,主管药师,本科 .
  • 基金资助:
    辽宁省自然科学基金(2014020051)

Effects of Licorice on Pharmacokinetics of Lovastatin in Hyperlipidemic Rats

ZHANG Yingying,LI Jihong   

  1. Department of Pharmacy,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China
  • Received:2016-12-21 Online:2017-04-30 Published:2017-04-19

摘要: 目的 研究高脂血症大鼠模型中甘草对洛伐他汀药代动力学过程的影响。方法 将 18 只 SD 大鼠随机分为对照组(n = 6)和实验组(n = 12)。实验组采用高脂饲料喂养大鼠,构建高脂血症大鼠模型,随机分为洛伐他汀单独给药组(n = 6)和洛 伐他汀与甘草联合给药组(n = 6)。联合给药组给予甘草颗粒,单独给药组给予相应体积的生理盐水,连续 7 d 后,2 组大鼠单剂 量灌胃给予洛伐他汀胶囊(20 mg/kg,0.5% CMC-Na 溶液)。分别于给药前和给药后不同时间点采集血浆样品,采用液相色谱- 质谱联用方法测定血药浓度,计算药代动力学参数,并进行组间比较。结果 长期给予甘草导致洛伐他汀代谢产物洛伐他汀酸在高脂血症大鼠中血浆暴露水平显著升高,联合给药组平均 Cmax 较单独给药组升高约 80%(P < 0.05),而 AUC0-t 和 AUC0-∞分别 升高 115%和 109%(P = 0.005 和 P = 0.027)。联合给药组与单独给药组比较,洛伐他汀的 Cmax 和 AUC 增加,但无统计学差异(P >0.05)。结论 甘草可抑制洛伐他汀在高脂血症大鼠体内的代谢,增加其体内暴露水平。

关键词: 洛伐他汀, 洛伐他汀酸, 甘草, 药代动力学, 高脂血症大鼠, 药物相互作用

Abstract: Objective To study the effect of licorice on the pharmacokinetics of lovastatin in hyperlipidemic rat model. Methods Eighteen rats were randomly divided into control group(n = 6)and test group(n = 12). Rats in the test group were administered high fat diet to construct hyperlipidemic rat model. The 12 hyperlipidemic rats were then randomly divided into two groups:lovastatin group(n = 6)and lovastatin combined with licorice group(n = 6). The rats in both groups were administered lovastatin capsule(20 mg/kg,0.5% CMC-Na solution)after receiving licorice(for lovastatin combined with licorice group)or saline(for lovastatin group)for 7 days. Blood samples were collected at different time points before and after the administration of lovastatin capsule. The plasma concentrations of lovastatin and lovastatin acid(an active metabolite of lovastatin)were determined by LC-MS/MS method. Pharmacokinetics parameters were calculated using DAS 2.0 software,and the two groups were compared using SPSS 18.0 software. Results Long-term administration of licorice resulted in a significant increase in the plasma level of lovastatin acid in the hyperlipidemic rat,and the corresponding mean Cmax was approximately 80% higher than that of the lovastatin group(P < 0.05),while AUC0-t and AUC0-∞ increased by 115% and 109%,respectively(P = 0.005 and P = 0.027). Cmax and AUC of lovastatin also increased,but there was no statistical significance(P > 0.05). Conclusion Licorice can inhibit the metabolism of lovastatin in hyperlipidemic rats and increase its exposure in vivo.

Key words: lovastatin, lovastatin acid, licorice, pharmacokinetics, hyperlipidemic rat, drug interaction

中图分类号: 

  • R977
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