中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2017, Vol. 46 ›› Issue (4): 345-348.doi: 10.12007/j.issn.0258-4646.2017.04.015

• 论著 • 上一篇    下一篇

视神经脊髓炎谱系疾病患者中水通道蛋白 4 抗体与视神经损害的相关性

于鹭,汤可娜,仲星星,李梅,管阳太   

  1. 第二军医大学附属长海医院神经内科,上海 200433
  • 收稿日期:2016-10-12 出版日期:2017-04-30 发布日期:2017-04-19
  • 通讯作者: 管阳太 E-mail:yangtaiguan@sina.com
  • 作者简介:于鹭(1992 -),女,硕士研究生 .
  • 基金资助:
    上海市优秀学术带头人计划(14XD1403400)

Correlation between Aquaporin-4 Antibody and Optic Neuropathy in Patients with Neuromyelitis Optica Spectrum Disorder

YU Lu,TANG Kena,ZHONG Xingxing,LI Mei,GUAN Yangtai   

  1. Department of Neurology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
  • Received:2016-10-12 Online:2017-04-30 Published:2017-04-19

摘要: 目的 探讨视神经脊髓炎谱系疾病(NMOSD)患者中水通道蛋白 4(AQP4)抗体与视神经损害的关系及其临床意义。方法 回顾性分析 2010 年 1 月至 2015 年 10 月我院经 AQP4 抗体检测确诊的 53 例 NMOSD 患者的临床与生化资料。根据是否有视 神经损害分为视神经损害组与无视神经损害组,比较 2 组患者的临床与生化特征。根据 AQP4 抗体是否阳性将患者分为 AQP4 抗体阳性组与阴性组,比较 2 组视神经损害发生率。分析 AQP4 抗体与视神经损害的相关性。结果 视神经损害组与无视神经 损害组比较,患者性别、发病年龄、病程、括约肌功能障碍发生率、外周血白细胞计数、谷丙转氨酶值、脑脊液蛋白值、脑脊液免 疫球蛋白指数及寡克隆带阳性率的差异无统计学意义(P > 0.05),复发次数、浅感觉减退发生率、血肌酐值及 AQP4 抗体阳性率 的差异有统计学意义(P < 0.05)。AQP4 抗体阳性组与 AQP4 抗体阴性组比较,视神经损害发生率的差异有统计学意义(F =4.93,P < 0.05)。AQP4 抗体与视神经损害发生呈正相关(r = 0.297,P < 0.05)。结论 NMOSD 患者 AQP4 抗体阳性易出现视神 经损害,两者的正相关关系有助于 NMOSD 患者视神经损害的早期预判及病情监测。

关键词: 视神经脊髓炎谱系疾病, 水通道蛋白 4 抗体, 视神经损害, 脑脊液

Abstract: Objective To determine the correlation between aquaporin-4 antibody(AQP4-Ab)and optic neuropathy in patients with neuromyelitis optica spectrum disorder(NMOSD). Methods The clinical and biochemical data of 53 patients with NMOSD diagnosis based on AQP4-Ab level in Changhai Hospital between January 2010 and October 2015 were retrospectively analyzed. According to optic neuropathy occurrence,the NMOSD patients were divided into optic neuropathy and non-optic neuropathy groups. Clinical and biochemical characteristics were compared between the two groups. According to the serum AQP4-Ab levels,the NMOSD patients were divided into AQP4-Ab seropositive and seronegative groups. The incidence of optic neuropathy was compared between the two groups. The correlation between optic neuropathy and AQP4-Ab levels was analyzed. Results Between the optic neuropathy and non - optic neuropathy groups,no significant differences in sex,age at onset,disease course,serum alanine aminotransferase levels,protein levels in cerebral spinal fluid,IgG index,and oligoclonal band were observed(P > 0.05). However,statistically significant differences were found in frequency,superficial sensory impairment,serum creatinine level,and serum AQP4-Ab leve(l P < 0.05). Between the AQP4-Ab seropositive and seronegative groups,a statistically significant difference in the incidence of optic neuropa- thy was observed(F = 4.93,P < 0.05).The incidence of optic neuropathy positively correlated with AQP4-Ab levels(r = 0.297,P < 0.05). Conclusion NMOSD patients with AQP4-Ab seropositivity could be prone to optic neuropathy,and the correlation may be beneficial to early diagnosis,therapy,and monitoring of NMOSD.

Key words: neuromyelitis optica spectrum disorder, aquaporin-4 antibody, optic neuropathy, cerebrospinal fluid

中图分类号: 

  • R744.5
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