中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2017, Vol. 46 ›› Issue (9): 825-829.doi: 10.12007/j.issn.0258-4646.2017.09.013

• 论著 • 上一篇    下一篇

钙卫蛋白在肿瘤坏死因子抑制剂治疗幼年特发性关节炎 临床应答中的预测作用

李晖,蔡玮,陈开澜   

  1. 武汉市妇女儿童医疗保健中心血液肿瘤科,武汉 430016
  • 收稿日期:2016-10-25 出版日期:2017-09-30 发布日期:2017-09-19
  • 通讯作者: 蔡玮 E-mail:caiweii918@163.com
  • 作者简介:李晖(1970 -),女,副主任医师,硕士

Correlation of Serum Calprotectin Expression with Clinical Response in Juvenile Idiopathic Arthritis Patients Treated with a Tumor Necrosis Factor Inhibitor

LI Hui,CAI Wei,CHEN Kailan   

  1. Department of Hematology and Oncology,Wuhan Medical and Health Center for Women and Children,Wuhan 430016,China
  • Received:2016-10-25 Online:2017-09-30 Published:2017-09-19

摘要: 目的 评估血清钙卫蛋白(MRP8/14)水平在肿瘤坏死因子(TNF)抑制剂治疗中国人群幼年特发性关节炎(JIA)患者临床应答中的预测作用。方法 纳入 72 例接受依那西普治疗 24 周的 JIA 患者和 30 例健康志愿者(HCs),采用免疫酶吸附法检测 JIA 患者基线期和 HCs 血清 MRP8/14 水平。临床应答定义为实现 ACR 儿科临床应答标准 ACRpedi 50。结果 JIA 患者中血清 MRP8/14 水平显著高于 HCs(P < 0.001)。基线期应答组患者血清 MRP8/14 水平显著高于不应答组(P < 0.001)。受试者工作特 征曲线显示,MRP8/14 水平预测临床应答曲线下面积为 0.823(95% CI:0.706~0.939)。进一步行单因素、多因素 logistic 回归分析 发现,血清 MRP8/14 高水平是临床应答的独立预测因素(P = 0.003)。结论 血清 MRP8/14 水平可作为可靠的、新颖的预测 TNF 抑制剂治疗 JIA 患者临床应答的生物标志物。

关键词: 幼年特发性关节炎, 钙卫蛋白, 肿瘤坏死因子抑制剂, 临床应答

Abstract: Objective To investigate the correlation of serum calprotectin(MRP8/14)expression with clinical response in Chinese juvenile idio pathic arthritis(JIA)patients treated with a tumor necrosis factor(TNF)inhibitor. Methods Seventy-two JIA patients and 30 health volunteers(HCs)were enrolled in this prospective study. All JIA patients received etanercept for 24 weeks. Serum was collected from JIA patients at baseline before treatment and from HCs. Clinical response was defined according to the American College of Rheumatology(ACR)Pedi 50 criteria. Results Serum MRP8/14 expression was greater in JIA patients than in HCs(P < 0.001). Serum MRP8/14 level was greater in responders than in non-responders(area under the receiver operating characteristic curve,0.823;95% CI:0.706-0.939). Univariate and multivariate logistic analysis showed that high serum MRP8/14 expression was an independent predictive factor for clinical response(P = 0.003). Conclusion Serum MRP8/14 level can be used as a convincing and novel biomarker for clinical response in JIA patients treated with a TNF inhibitor

Key words: juvenile idiopathic arthritis, calprotectin, tumor necrosis factor inhibitor, clinical response

中图分类号: 

  • R593.22
[1] 范晓蕾, 刘中华, 岳涛, 何东仪. 血清TNF-α、IL-1β、IL-6和IL-17表达水平在阿达木单抗治疗活动性类风湿关节炎中的疗效预测作用[J]. 中国医科大学学报, 2018, 47(6): 556-561.
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