中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2017, Vol. 46 ›› Issue (12): 1076-1081.doi: 10.12007/j.issn.0258-4646.2017.12.005

• 论著 • 上一篇    下一篇

40周岁及以上双胎妊娠产妇的临床结局分析

李洋洋, 那全, 刘彩霞, 尹少尉   

  1. 中国医科大学附属盛京医院妇产科, 沈阳 110004
  • 收稿日期:2017-02-26 出版日期:2017-12-30 发布日期:2017-12-08
  • 通讯作者: 刘彩霞 E-mail:liucx1716@163.com
  • 作者简介:李洋洋(1991-),女,硕士研究生.
  • 基金资助:
    国家卫生计生委公益性行业科研专项(201402006);辽宁省产科疾病转化医学研究中心及协同研究网络建设(2014225007)

Clinical Outcome Analysis of Twin Pregnancies in Women Over the Age of 40 Years

LI Yangyang, NA Quan, LIU Caixia, YIN Shaowei   

  1. Department of Gynecology and Obstetrics, Shengjing Hospital, China Medical University, Shenyang 110004, China
  • Received:2017-02-26 Online:2017-12-30 Published:2017-12-08

摘要: 目的 探讨40周岁及以上双胎妊娠产妇在围产期并发症及妊娠结局上的差异。方法 对国内12家医院2013年1月至12月住院的3 127例双胎妊娠产妇临床资料进行回顾性分析,分别比较≥ 40周岁、35~<40周岁及18~<35周岁产妇围产期并发症及妊娠结局的差异。结果 ≥ 40周岁组与35~<40周岁组及18~<35周岁组相比产后出血、流产、早期早产、早产活产儿中低出生体质量儿及新生儿轻度窒息发生率明显升高,差异均有统计学意义(均P < 0.05);≥ 40周岁组妊娠期高血压疾病发生率高于35~<40周岁及18~<35周岁组,但差异无统计学意义(P > 0.05)。结论 40周岁及以上双胎妊娠产妇更易发生母体并发症及围产儿不良预后。因此,加强孕期及围产期管理,尽可能延长妊娠孕周,对改善围产儿预后具有重要意义。

关键词: 双胎妊娠, 高龄产妇, 辅助生殖, 产后出血, 新生儿窒息

Abstract: Objective To examine perinatal complications and outcomes of twin pregnancies in women aged over 40 years. Methods A retrospective study was performed on the clinical data of 3 127 twin pregnancies,managed in 12 national hospitals from January 2013-December 2013,to analyze differences in perinatal complications and outcomes between women aged over 40 years,and those aged 35 to <40 years and 18 to <35 years. Results For twin pregnancies,the incidence of postpartum hemorrhage,abortion,early preterm birth,termination of gestation,very low birth weight infants,mild neonatal asphyxia,and preterm births in women aged over 0 years was significantly higher than in women aged 35 to <40 years and 18 to <35 years (P < 0.05). Among women aged over 40 years and those aged 35 to <40 years,the incidence of gestational hypertension was not significantly higher than in women aged 18 to <35 years for twin pregnancies (P > 0.05). Conclusion Women aged over 40 years with twin pregnancies were more likely to develop maternal complications and poor perinatal outcomes. Therefore,twin pregnancies in women aged over 40 years should receive comprehensive perinatal management to extend the gestation and improve the perinatal prognosis.

Key words: twin pregnancy, advanced maternal age women, assisted reproductive technology, postpartum hemorrhage, neonatal asphyxia

中图分类号: 

  • R714.7
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[1] 崔红,陈静,刘彩霞. 2001年和2011年产后出血的救治及高危因素的临床分析[J]. 中国医科大学学报, 2013, 42(6): 532-534.
[2] 陈肖侠,解丽梅. 超声诊断双胎妊娠并单脐动脉胎儿异常分析[J]. 中国医科大学学报, 2013, 42(5): 451-453.
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