中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2017, Vol. 46 ›› Issue (12): 1129-1132,1137.doi: 10.12007/j.issn.0258-4646.2017.12.015

• 论著 • 上一篇    下一篇

肥胖伴牙周炎患者龈沟液及血清中脂联素与内脂素的表达

胥丹妮, 靳赢, 王越, 宋利明, 林晓萍   

  1. 中国医科大学附属盛京医院口腔科, 沈阳 110004
  • 收稿日期:2017-06-02 出版日期:2017-12-30 发布日期:2017-12-08
  • 通讯作者: 林晓萍 E-mail:xiaoping_ba@126.com
  • 作者简介:胥丹妮(1991-),女,医师,硕士研究生.

Expression of Adiponectin and Visfatin in the Gingival Crevicular Fluid and Serum of Patients with Obesity and Chronic Periodontitis

XU Danni, JIN Ying, WANG Yue, SONG Liming, LIN Xiaoping   

  1. Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 110004, China
  • Received:2017-06-02 Online:2017-12-30 Published:2017-12-08

摘要: 目的 检测肥胖伴牙周炎患者龈沟液及血清中脂联素与内脂素的表达水平。方法 本研究共纳入80例我科就诊患者,分为4组。其中对照组20例(H组)、牙周炎组20例(CP组)、肥胖组20例(OB组)、肥胖伴牙周炎组20例(OB+CP组);记录患者的一般信息和临床指标;收集龈沟液及静脉血清样本,采用ELISA法测定龈沟液及血清中脂联素与内脂素的表达水平;利用SPSS 17.0软件包对数据进行统计学分析。结果 CP组、OB组及OB+CP组血清中脂联素的浓度低于H组(P < 0.05)。OB+CP组血清中脂联素的浓度低于CP组及OB组(P < 0.05)。CP组、OB组及H组龈沟液中脂联素的浓度高于OB+CP组(P < 0.05)。CP组、OB组及H组血清中内脂素的浓度低于OB+CP组(P < 0.05)。结论 肥胖可能通过抑制脂联素表达、促进内脂素的表达加重牙周组织的破坏。

关键词: 肥胖, 牙周炎, 脂联素, 内脂素

Abstract: Objective To investigate the expression levels of adiponectin and visfatin in the gingival crevicular fluid (GCF) and serum of patients with obesity and chronic periodontitis. Methods The study included 80 patients. Among them,20 were healthy controls (H group),20 had periodontitis (CP group),20 had obesity (OB group),and 20 had both obesity and periodontitis (OB+CP group). The patients' baseline information and clinical parameters were recorded,and the GCF and serum were collected. The concentration of adiponectin and visfatin in the GCF and serum were then assayed using ELISA. Use the SPSS 17.0 software package for statistical analysis. Results The concentration of adiponectin in the serum of the CP group,the OB group,and the OB+CP group were significantly lower than that of the H group (P < 0.05). The concentration of adiponectin in the serum of the OB+CP group was lower than that of both the CP and OB groups (P < 0.05). The concentration of adiponectin in the GCF of the CP group,the OB group,and the H group were higher than that of the OB+CP group (P < 0.05). The concentration of adiponectin in the GCF of the CP group,the OB group,and the H group were lower than that of the OB+CP group (P < 0.05). Conclusion Obesity may aggravate the destruction of periodontal tissue by inhibiting the expression of adiponectin and promoting the expression of visfatin.

Key words: obesity, periodontitis, adiponectin, visfatin

中图分类号: 

  • R781.4
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