中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (1): 32-35.doi: 10.12007/j.issn.0258-4646.2018.01.008

• 论著 • 上一篇    下一篇

类风湿关节炎患者甲状腺相关抗体的临床分析

于婷婷, 张宁   

  1. 中国医科大学附属盛京医院第二风湿免疫科, 沈阳 110004
  • 收稿日期:2017-04-28 出版日期:2018-01-30 发布日期:2017-12-23
  • 通讯作者: 张宁 E-mail:zhangning@sj-hsopital.org
  • 作者简介:于婷婷(1991-),女,硕士研究生.
  • 基金资助:
    辽宁省自然科学基金(2014021081)

Clinical Analysis of Thyroid-associated Antibodies in Patients with Rheumatoid Arthritis

YU Tingting, ZHANG Ning   

  1. Department of Rheumatology, Shengjing Hospital, China Medical University, Shenyang 110004, China
  • Received:2017-04-28 Online:2018-01-30 Published:2017-12-23

摘要: 目的 研究类风湿关节炎疾病活动度(DAS28)与甲状腺相关抗体之间的关系。方法 以住院治疗的确诊初发RA患者300例为研究对象,按甲状腺相关抗体的水平分为双阴性组、单阳性组、双阳性组,记录其年龄、初诊的肿胀关节数、压痛关节数、红细胞沉降率及甲状腺过氧化物酶抗体和甲状腺球蛋白抗体检测结果,计算DAS28值,并进行分析。结果 甲状腺相关抗体阳性组DAS28高于阴性组,差异有统计学意义,但单阳性组与双阳性组之间差异无统计学意义。甲状腺相关抗体与DAS28无明显相关性。结论 甲状腺相关抗体虽然与DAS28无相关性,但其可能对DAS28有一定的影响,提示自身免疫性疾病之间有一定的相互作用。

关键词: 类风湿关节炎, 甲状腺相关抗体, 疾病活动度, 自身免疫疾病

Abstract: Objective To study the relationship between rheumatoid arthritis (RA) disease activity (DAS28) and thyroid-associated antibodies. Methods Three hundred patients with newly diagnosed RA who were hospitalized were divided into three groups, namely the double-negative, single-positive, and double-positive groups. We recorded the ages of the patients, the number of swollen joints and tender joints, and the values of erythrocyte sedimentation rate, thyroid peroxidase antibody, and thyroglobulin antibody to calculate the DAS28 score and analyze the results. Results The differences in DAS28 score among the three groups were statistically significant, and the DAS28 scores in the positive group was higher than that in the negative group. However, no significant differences were found between the single-positive group and the double-positive group. Thyroid-related antibodies were not significantly associated with DAS28 score. Conclusion Although the thyroid-associated antibody level did not correlate with DAS28 score, a certain effect may exist on the DAS28 score, suggesting a certain interaction among autoimmune diseases.

Key words: rheumatoid arthritis, thyroid related antibodies, disease activity, autoimmune diseases

中图分类号: 

  • R593.22
[1] 蔡茂文,张晶,周彬.彝族人群类风湿关节炎患者甲状腺功能状况分析及临床意义[J]. 实用医院临床杂志,2013,10(4):110-112. DOI:10.3969/j.issn.1672-6170.2013.04.039.
[2] EMAMIFAR A, HANGAARD J. Thyroid disorders in patients with newly diagnosed rheumatoid arthritis is associated with poor initial treatment response evaluated by disease activity score in 28 joints-C-reactive protein (DAS28-CRP):An observational cohort study[J]. Medicine (Baltimore),2017,96(43):e8357.DOI:10.1097/MD.0000000000008357.
[3] LAZÚROVÁ I, JOCHMANOVÁ I, BENHATCHI K. Autoimmune thyroid disease and rheumatoid arthritis:relationship and the role of genetics[J]. Immunol Res,2014,60(2/3):193-200. DOI:10.1007/s12026-014-8598-9.
[4] HEZARKHANI S, SEDIGHI S, AGHAEI M, et al. Rheumatologic manifestations in Iranian patients with autoimmune thyroid diseases[J]. J Clin Diagn Res:JCDR,2014,8(10):MC06-8.DOI:10.7860/JCDR/2014/7974.4981.
[5] KOSZARNY A, MAJDAN M, SUSZEK D, et al. Relationship between rheumatoid arthritis activity and antithyroid antibodies[J]. Pol Arch Med Wewn,2013,123(7-8):394-400.DOI:10.20452/pamw.1829.
[6] RATERMAN HG,VOSKUYL AE,SIMSEK S, et al. Increased progression of carotid intima media thickness in thyroid peroxidase antibodies-positive rheumatoid arthritis patients[J].Eur J Endocrinol,2013,169(6):751-757.DOI:10.1530/EJE-13-0394.
[7] BESEDOVSKY H. Network of immune-neuroendocrine interactions[J]. Clin Exp Immunol,1977,27(1):1-12.
[8] 施春花,王友莲,尚可,等.类风湿关节炎甲状腺状况的临床研究[J]. 江西医药,2011,46(5):441-443.DOI:10.3969/j.issn.1006-2238.2011.05.028.
[9] ZHANG R, LUAN M, SHANG Z, et al. RADB:a database of rheumatoid arthritis-related polymorphisms[J]. Database (Oxford),2014,2014:bau090. DOI:10.1093/database/bau090.
[10] ATZENI F,DORIA A,GHIRARDELLO A,et a1.Organ-specific autoantiboies in patients with rheumatoid arthritis treated with adalimumab:a prospective long-term follow-up[J].Autoimmunity,2008,41(1):87-91. DOI:10.1080/08916930701620050.
[11] 胡庆伟,徐芳.类风湿关节炎患者合并甲状腺疾病的临床分[J].四川医学,2014,35(8):1003-1005.DOI:10.16252/j.cnki.issn1004-0501-2014.08.030.
[12] SCHOELS M, ALASTI F, SMOLEN JS. Evaluation of newly proposed remission cut-points for disease activity score in 28 joints (DAS28) in rheumatoid arthritis patients upon IL-6 pathwayinhibition[J]. Arthritis Res Ther,2017,19(1):155. DOI:10.1186/s13075-017-1346-5.
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