中国医科大学学报

中国医科大学学报
  • 中文核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (2): 119-122,144.doi: 10.12007/j.issn.0258-4646.2018.02.006

• 论著 • 上一篇    下一篇

小脑锌指结构4在子宫内膜癌组织中的表达及意义

马剑, 孔繁菲, 丛蓉, 马晓欣   

  1. 中国医科大学附属盛京医院妇产科, 沈阳 110020
  • 收稿日期:2017-12-05 出版日期:2018-02-28 发布日期:2018-01-11
  • 通讯作者: 马晓欣 E-mail:maxiaoxin666@aliyun.com
  • 作者简介:马剑(1990-),女,博士研究生.
  • 基金资助:
    国家自然科学基金(81472438,81272874);沈阳市科学技术计划(F14-158-9-47);盛京自由研究者基金(201601)

Expression of ZIC4 in Endometrial Carcinoma and Its Significance

MA Jian, KONG Fanfei, CONG Rong, MA Xiaoxin   

  1. Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang 110020, China
  • Received:2017-12-05 Online:2018-02-28 Published:2018-01-11

摘要: 目的 检测小脑锌脑指结构4(ZIC4)在子宫内膜癌组织中的表达,探讨ZIC4表达与子宫内膜癌患者临床病理参数的关系及临床意义。方法 应用免疫组化方法检测子宫内膜癌、非典型增生及正常子宫内膜石蜡标本中ZIC4的表达结果 非典型增生与子宫内膜癌组织中ZIC4的阳性率高于正常内膜组织。ZIC4表达与子宫内膜癌临床分期、分化、子宫浸润深度以及淋巴结转移有关。生存分析显示ZIC4低表达组子宫内膜癌患者预后更佳。结论 ZIC4在子宫内膜癌组织中的表达水平明显升高。ZIC4可用于监测子宫内膜癌患者预后。

关键词: ZIC4, 子宫内膜癌, 临床病理参数

Abstract: Objective To investigate zinc finger of the cerebellum 4(ZIC4) expression in endometrial cancer tissue and its relationship with clinicopathological parameters.Methods Immunohistochemistry was used to detect ZIC4 expression in endometrial paraffin specimens.Results The positivity rate of ZIC4 expression in atypical hyperplasia and endometrial carcinoma was higher than that in normal endometrial tissue. ZIC4 expression was correlated with the clinical stage,differentiation,depth of uterine invasion,and lymph node metastasis of endometrial cancer. Survival analysis revealed that patients with endometrial cancer who had low ZIC4 expression levels had better prognosis.Conclusion The ZIC4 expression level in endometrial carcinoma is significantly increased;thus,ZIC4 expression level can be used to monitor the prognosis of patients with endometrial cancer.

Key words: zinc finger of the cerebellum 4, endometrial cancer, clinicopathological parameter

中图分类号: 

  • R3
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