中国医科大学学报

中国医科大学学报
  • 中文核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
  • BA、CA收录

中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (2): 167-170.doi: 10.12007/j.issn.0258-4646.2018.02.016

• 综述 • 上一篇    下一篇

盐敏感性高血压与膳食功能因子

梁思聪1, 陈思娇2, 祝之明3   

  1. 1. 中国医科大学临床一系八年制实验班, 沈阳 110001;
    2. 中国医科大学附属第一医院老年医学科, 沈阳 110001;
    3. 陆军军医大学大坪医院高血压与内分泌科, 全军高血压及代谢病中心, 重庆 400042
  • 收稿日期:2017-08-21 出版日期:2018-02-28 发布日期:2018-01-11
  • 通讯作者: 陈思娇 E-mail:csjcmu@sina.com
  • 作者简介:梁思聪(1996-),女,本科在读.
  • 基金资助:
    国家重点基础研究发展计划(2012CB517800);中国医科大学2017年大学生创新创业训练计划省级项目(201710159000123)

Salt Sensitivity Hypertension and Dietary Functional Factors

LlANG Sicong1, CHEN Sijiao2, ZHU Zhiming3   

  1. 1. Eight-year-system Experimental Class, The First Department of Clinical Medicine, China Medical University, Shenyang 110122, China;
    2. Department of Geriatrics, The First Hospital, China Medical University, Shenyang 110001, China;
    3. Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University, Chongqing 400042, China
  • Received:2017-08-21 Online:2018-02-28 Published:2018-01-11

摘要: 高血压患者多是盐敏感者,控制食盐摄入意义重大。本综述阐述盐敏感性高血压(SSHT)发生发展的病理生理机制(钠通道异常、内皮功能受损、钠泵异常及相关基因等),介绍膳食功能因子(辣椒素、咖啡因、芹菜素、牛磺酸、姜黄素、薄荷醇、黄连素)对SSHT的影响途径,为从人群中筛查盐敏感者,从膳食角度对高血压进行预防和治疗提供理论依据。

关键词: 盐敏感, 高血压, 膳食功能因子

Abstract: Of those who have hypertension,several patients are salt sensitive and need to restrict their salt intake. This article elucidates the physiological and pathological mechanisms of salt-sensitive hypertension (SSHT),including the dysfunction of the epithelial sodium channel (ENaC),epithelial damage,and the malfunction of the sodium pump,and relative genetic study,followed by a comparison of various salt-sensitivity examination methods. Another important discussion is about the influence of dietary factors (capsaicin,caffeine,apigenin,taurine,curcumin,menthol,and berberine) on SSHT. This review provides a solid foundation for understanding the biology of SSHT,screening of the salt-sensitive population,and prevention and cure of SSHT through everyday diet.

Key words: salt sensitivity, hypertension, dietary functional factor

中图分类号: 

  • R544.1
[1] 国家卫生和计划生育委员会. 中国卫生和计划生育统计年鉴[M]. 北京:中国协和医科大学出版社,2013.
[2] SMITH SC,FELDMAN TE,HIRSHFELD JW,et al. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention:a report of the American college of cardiology/American heart association task force on practice guidelines (ACC/AHA/SCAI writing committee to update the 2001 guidelines for percutaneous coronary intervention)[J]. J Am Coll Cardiol,2006,47(1):e1-e121. DOI:10.1016/j.jacc.2005.12.001.
[3] 牟建军,刘治全. 关注盐和盐敏感性提高我国高血压防治水平[J]. 中华高血压杂志,2010,3:201-202.
[4] 陈思娇,刘道燕. 高血压防治——科学证据解读[M]. 北京:人民卫生出版社,2017.
[5] 李玉明,刘治全,杨鼎颐. 盐敏感性高血压Na+·K+-ATP酶α1亚单位的基因改变[J]. 北京医科大学学报,1994,26(S1):244-245.
[6] LIU K,LIU J,HUANG Y,et al. Alpha-adducin Gly460Trp polymorphism and hypertension risk:a meta-analysis of 22 studies including 14303 cases and 15961 controls[J]. PLoS One,2010,5(9):e13057. DOI:10.1371/journal.pone.0013057.
[7] ZHANG H,PU Y,CHEN J,et al. Gastrointestinal intervention ameliorates high blood pressure through antagonizing overdrive of the sympathetic nerve in hypertensive patients and rats[J]. J Am Heart Assoc,2014,3(5):e000929. DOI:10.1161/JAHA.114.000929.
[8] DUARTE T,MENEZES-RODRIGUES FS,GODINHO RO. Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle[J]. J Pharmacol Exp Ther,2012,341(3):820-828. DOI:10.1124/jpet.112.192997.
[9] ROY A,AL-QUSAIRI L,DONNELLY BF,et al. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action[J]. J Clin Invest,2015,125(9):3433-3448. DOI:10.1172/JCI75245.
[10] ZHU J,HUANG T,LOMBARD JH. Effect of high-salt diet on vascular relaxation and oxidative stress in mesenteric resistance arteries[J]. J Vasc Res,2007,44(5):382-390. DOI:10.1159/000102955.
[11] CITTERIO L,SIMONINI M,ZAGATO L,et al. Genes involved in vasoconstriction and vasodilation system affect salt-sensitive hypertension[J]. PLoS One,2011,6(5):e19620. DOI:10.1371/journal.pone.0019620.
[12] 汪洋,牟建军,刘富强,等. 高盐喂食对Dahl盐敏感大鼠肾小管上皮向间质转化和肾脏纤维化的影响[J]. 中华高血压杂志,2015, 23(3):238-244. DOI:10.16439/j.cnki.1673-7245.2015.03.013.
[13] WALKOWSKA A,PAWLAK M,JANE SM,et al. Effects of high and low sodium diet on blood pressure and heart rate in mice lacking the functional grainyhead-like 1 gene[J]. Physiol Res,2017,66(1):163-165.
[14] DIAO Z,ASICO LD,VILLAR VA,et al. Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice[J]. Free Radic Biol Med,2017,106:80-90. DOI:10.1016/j.freeradbiomed.2017.02.021.
[15] HUANG BS,AMIN MS,LEENEN FH. The central role of the brain in salt-sensitive hypertension[J]. Curr Opin Cardiol,2006,21(4):295-304. DOI:10.1097/01.hco.0000231398.64362.94.
[16] CHEN K,FU C,CHEN C,et al. Role of GRK4 in the regulation of arterial AT1 receptor in hypertention[J]. J Am Soc Hypertens,2016,10(Suppl 1):e3. DOI:10.1016/j.jash.2016.06.011.
[17] OSBORN JW,OLSON DM,GUZMAN P,et al. The neurogenic phase of angiotensin Ⅱ-salt hypertension is prevented by chronic intracerebroventricular administration of benzamil[J]. Physiol Rep,2014,2(2):e00245. DOI:10.1002/phy2.245.
[18] WEINBERGER MH. Salt sensitivity of blood pressure in humans[J]. Hypertension,1996,27(3/2):481-490.
[19] WEIR MR,DENGEL DR,BEHRENS MT,et al. Salt-induced increases in systolic blood pressure affect renal hemodynamics and proteinuria[J]. Hypertension,1995,25(6):1339-1344.
[20] KASAGI F,AKAHOSHI M,SHIMAOKA K. Relation between cold pressor test and development of hypertension based on 28-year follow-up[J]. Hypertension,1995,25(1):71-76.
[21] 王征,韩飞舟,杨建涛,等. 急性静脉盐水负荷试验与冷加压试验检测盐敏感性的对照研究[J]. 中华保健医学杂志,2012, 14(1):13-15.
[22] FALKNER B,ONESTI G,ANGELAKOS ET,et al. Cardiovascular response to mental stress in normal adolescents with hypertensive parents. Hemodynamics and mental stress in adolescents[J]. Hypertension,1979,1(1):23-30.
[23] XIE C,WANG DH. Effects of a high-salt diet on TRPV-1-dependent renal nerve activity in dahl salt-sensitive rats[J]. Am J Nephrol,2010,32(3):194-200. DOI:10.1159/000316528.
[24] LI L,WANG F,WEI X,et al. Transient receptor potential vanilloid 1 activation by dietary capsaicin promotes urinary sodium excretion by inhibiting epithelial sodium channel α subunit-mediated sodium reabsorption[J]. Hypertension,2014,64(2):397-404. DOI:10.1161/HYPERTENSIONAHA.114.03105.
[25] YU H,YANG T,GAO P,et al. Caffeine intake antagonizes salt sensitive hypertension through improvement of renal sodium handling[J]. Sci Rep,2016,6:25746. DOI:10.1038/srep25746.
[26] 蒲云飞. 植物多酚拮抗高盐升压作用及保护靶器官的机制研究[D]. 第三军医大学,2013.
[27] SUN Q,WANG B,LI Y,et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension randomized,double-blind,placebo-controlled study[J]. Hypertension,2016,67(3):541-549. DOI:10.1161/HYPERTENSIONAHA.115.06624.
[28] CHEANG WS,LAM MY,WONG WT,et al. Menthol relaxes rat aortae,mesenteric and coronary arteries by inhibiting calcium influx[J]. Eur J Pharmacol,2013,702(1/3):79-84. DOI:10.1016/j.ejphar.2013.01.028.
[29] WANG Y,DING Y. Berberine protects vascular endothelial cells in hypertensive rats[J]. Int J Clin Exp Med,2015,8(9):14896-14905.
[30] SAN CHEANG W,YUEN NGAI C,YEN TAM Y,et al. Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress[J]. Sci Rep,2015,5:10340. DOI:10.1038/srep10340.
[1] 李雪佳, 李宇, 李晓鸥, 景可晖, 张茜, 李飞. 肿瘤坏死因子α与高血压病合并阻塞型睡眠呼吸暂停综合征的相关性[J]. 中国医科大学学报, 2018, 47(6): 519-521.
[2] 王佳莉,任卫东,王欣,赵梦峤. 超声动脉分析技术评价妊娠期高血压患者的颈动脉 径向应变和应变率[J]. 中国医科大学学报, 2017, 46(8): 686-688.
[3] 谭昭,李文歌. 厄贝沙坦延缓高血压合并糖尿病肾病患者肾病的进展[J]. 中国医科大学学报, 2017, 46(11): 1024-1027.
[4] 周飞,李金凤,明君,侯铁铎. 北方某煤矿集团高血压矿工领悟社会支持、自尊和 幸福感的相关性分析[J]. 中国医科大学学报, 2017, 46(10): 917-920.
[5] 张添甜 ,张潇怡 ,赵紫薇 ,孙光 ,牛一蒙 ,林杰. 原发高血压老年患者低舒张压对心脏舒张功能的影响[J]. 中国医科大学学报, 2016, 45(6): 514-517.
[6] 张潇怡, 问文敏, 张添甜, 赵紫薇, 孙光. 老年原发性高血压合并舒张性心力衰竭患者的临床特点分析[J]. 中国医科大学学报, 2015, 44(9): 803-805.
[7] 吴宝刚,郝瑩,李乃静,白雪,周勇. 原发性高血压并左心室肥厚与基质金属蛋白酶[J]. 中国医科大学学报, 2015, 44(6): 485-488.
[8] 付龙,孙溢晗,张月兰. MTHFR基因C677T多态性与H型高血压合并冠心病患者HCY、冠状动脉病变的关系[J]. 中国医科大学学报, 2015, 44(4): 351-356.
[9] 刘红梅,史丽丽,祝维萱. 护理干预对高血压患者睡眠质量及其不良情绪的影响[J]. 中国医科大学学报, 2015, 44(11): 1020-1023.
[10] 李飞,胡健. 血浆C末端内皮素1前体与高血压肾损害的相关性[J]. 中国医科大学学报, 2014, 43(6): 564-565.
[11] 李黎光,张信芳,刘轶丹,钟凯,刘学文. 121例椎-基底动脉延长扩张症患者不同临床特征系统分析[J]. 中国医科大学学报, 2014, 43(11): 1003-1007.
[12] 赵雅宁,王珠,李建民,刘乐,常学优,陈长香 . 内质网应激相关分子CHOP和磷酸化JNK在高血压全脑缺血大鼠海马区的表达[J]. 中国医科大学学报, 2013, 42(5): 431-435.
[13] 左光银,于宏伟,袁玉会,张颜礼,景方坤,邹鹏. 不同术式治疗高血压脑出血的疗效比较[J]. 中国医科大学学报, 2012, 41(6): 565-566.
[14] 裴丽峰 , , 韩英, 向东贤, 胡健. 老年高血压患者血浆同型半胱氨酸浓度与颈动脉内膜-中层厚度相关性的临床研究[J]. 中国医科大学学报, 2012, 41(2): 166-168.
[15] 孙广萍,于李汀,边晓慧,杨旭,王艳秋,李德天. NADPH氧化酶参与机械牵张大鼠血管平滑肌细胞MCP-1mRNA的生成[J]. 中国医科大学学报, 2012, 41(11): 1014-1017.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!

中国医科大学学报版权所有©2018

未经允许,严禁擅自转载本站图文资料

地址:中国 沈阳市沈北新区蒲河路77号 110122

辽ICP备05014850

JOURNAL OF CHINA MEDICAL UNIVERSITY

ADDRESS: NO.77 PUHE ROAD

SHENYANG NORTH NEW AREA, SHENYANG

LIAONING PROVINCE, P.R. CHINA