中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (3): 198-201.doi: 10.12007/j.issn.0258-4646.2018.03.002

• 论著 • 上一篇    下一篇

利用频域光学相干断层扫描分析高度近视患者黄斑区视网膜外核层厚度

陈禹橦, 刘贤洁, 刘美丹, 马小力   

  1. 中国医科大学附属第一医院眼科, 沈阳 110001
  • 收稿日期:2017-12-02 出版日期:2018-03-30 发布日期:2018-03-24
  • 通讯作者: 马小力 E-mail:xiaolimax@hotmail.com
  • 作者简介:陈禹橦(1990-),女,医师,硕士研究生.
  • 基金资助:
    国家自然科学基金(81200656);辽宁省自然科学基金(201602844)

Application of Spectral-domain Optical Coherence Tomography in the Measurement of the Macular Outer Nuclear Layer in Patients with High Myopia

CHEN Yutong, LIU Xianjie, LIU Meidan, MA Xiaoli   

  1. Department of Ophthalmology, The First Hospital, China Medical University, Shenyang 110001, China
  • Received:2017-12-02 Online:2018-03-30 Published:2018-03-24

摘要: 目的 应用频域光学相干断层扫描技术(SD-OCT)定量观察高度近视患者与正视者黄斑区视网膜外核层(ONL)厚度的差异,分析高度近视患者视网膜ONL厚度的变化特点及分布规律。方法 收集受检者78例78眼,根据其等效球镜(SE)分为2组,其中正视组(-0.25D~+0.25D) 24例24眼,高度近视组(SE<-6.00D) 54例54眼。通过海德堡Spectralis SD-OCT的后极部非对称性分析模式对受检者黄斑区视网膜进行扫描,以早期糖尿病性视网膜病变治疗研究标准将黄斑区进行分区,通过定量分析比较不同区域高度近视患者与正视者视网膜ONL厚度的差异。结果 黄斑中央区视网膜ONL厚度高于黄斑区上方、鼻侧、下方和颞侧,差异均有统计学意义(P < 0.001);黄斑区下方视网膜ONL厚度低于中央、上方、鼻侧、颞侧,差异均有统计学意义(P < 0.001),其余各分区之间比较ONL厚度的差异无统计学意义。高度近视组中央、上方、鼻侧、下方、颞侧视网膜ONL厚度均低于正视组对应区域,差异均有统计学意义(P < 0.05)。结论 视网膜ONL厚度分布存在区域性特征,高度近视患者视网膜ONL厚度变薄。

关键词: 外核层, 光学相干断层扫描, 高度近视, 视网膜厚度

Abstract: Objective To quantitatively analyze the difference in retinal thickness of the macular outer nuclear layer (ONL) between high myopia patients and normal subjects using spectral-domain optical coherence tomography (SD-OCT). Methods Seventy-eight participants (78 eyes) were divided into normal control group and high myopia group,according to the spherical equivalent (SE) of each eye. There were 24 cases (24 eyes) in the normal control group (-0.25 D~+0.25 D) and 54 cases (54 eyes) in the high myopia group (SE<-6.00 D). The macular retina was scanned using the posterior pole asymmetry analysis mode of the Heidelberg Spectralis (SD-OCT) system and divided into 9 areas according to Early Treatment of Diabetic Retinopathy Study. Quantitative analysis was performed to compare the difference in retinal thickness of the macular ONL in each area between the high myopia and normal control groups. Results The ONL thickness in the central area of the macular retina was significantly higher than that in the superior,nasal,inferior,and temporal areas (P < 0.001 for all comparisons). The ONL thickness in the inferior area of the macular retina was significantly lower than that in the central,superior,nasal,and temporal areas (P < 0.001 for all comparisons). In other sub-regions,no difference in the ONL thickness was found. The ONL thickness in the central,superior,nasal,inferior,and temporal areas was significantly lower in the high myopia group than in the normal control group (P < 0.05 for all comparisons). Conclusion Regional variation is observed in the ONL thickness. The ONL thickness in the macular area of patients with high myopia is thinner.

Key words: outer nuclear layer, optical coherence tomography, high myopia, retinal thickness

中图分类号: 

  • R774.5
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[4] 马小力,陈禹橦,刘贤洁,李丹丹,张宏伟,宁宏. 频域光学相干断层扫描测量青光眼视网膜神经纤维层厚度的可重复性研究[J]. 中国医科大学学报, 2016, 45(3): 197-200.
[5] 马小力,刘贤洁,陈禹橦,李丹丹,张宏伟,华瑞. 利用频域光学相干断层扫描测量青光眼视盘旁萎缩区[J]. 中国医科大学学报, 2015, 44(12): 1057-1060.
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