中国医科大学学报

中国医科大学学报
  • 中文核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
  • BA、CA收录

中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (3): 212-216.doi: 10.12007/j.issn.0258-4646.2018.03.005

• 论著 • 上一篇    下一篇

家兔失血性休克死后肝脏CT影像学变化与死亡时间的关系

郑吉龙, 倪首涛, 章彪, 霍德民, 赵开放, 刘夏, 杨森   

  1. 中国刑事警察学院法医系法医病理教研室, 沈阳 110035
  • 收稿日期:2017-07-11 出版日期:2018-03-30 发布日期:2018-03-24
  • 通讯作者: 郑吉龙 E-mail:jilong412@126.com
  • 作者简介:郑吉龙(1976-),男,教授,博士.
  • 基金资助:
    公安部技术研究计划(2016JSYJC56);国家级大学生创新训练计划(2017DXSCXXLJH049);中国刑警学院研究生创新能力提升项目(2017JKF075)

Experimental Study on Estimating the Postmortem Interval in Rabbits Hemorrhagic Shock Death Model Using Liver Computed Tomography Images

ZHENG Jilong, NI Shoutao, ZHANG Biao, HUO Demin, ZHAO Kaifang, LIU Xia, YANG Sen   

  1. Department of Forensic Medicine, National Police University of China, Shenyang 110035, China
  • Received:2017-07-11 Online:2018-03-30 Published:2018-03-24

摘要: 目的 研究家兔失血性休克死后129 h内肝脏CT影像学的变化与死后经过时间的关系。方法 以失血性休克处死家兔,在死后不同时间对家兔进行肝脏螺旋CT扫描,选取第一腰椎层面测定肝组织平均CT值和肝脏面积/腰椎面积。结果 肝脏面积/腰椎面积在肝窗上呈现"相对不变-快速减小-缓慢减小"的时间变化,肝脏组织平均CT值呈先上升后下降的总体趋势。将每个参数的测量值进行多项式运算,获得了更能体现2项指标与死亡时间关系的二项式回归方程,均具有高度的统计学意义(P均<0.01)。结论 CT扫描可动态、客观显示家兔死后肝脏的影像学变化,肝脏组织平均CT值变化对早期死亡时间推断更准确,肝脏面积/腰椎面积变化对中晚期死亡时间推断更灵敏。

关键词: 法医病理学, 死亡时间, 肝脏面积/腰椎面积, 肝脏组织平均CT值

Abstract: Objective To investigate the relationship between changes in the liver computed tomography (CT) images and the postmortem interval (PMI) of rabbits 129 h after their death due to hemorrhagic shock. Methods CT scanning was used to investigate the hemorrhagic shock death model in 23 rabbits to identify the postmortem cerebral changes from 0 h to 129 h after death. Results The liver or lumbar area in the liver window showed the following characteristic changes:from unchanged,to rapid shrinkage,to slow shrinkage;the mean CT values of the liver initially increased and subsequently decreased. The regression equations for the relationship between the two indices and PMI were established by surgery,and they all had statistical significance (P < 0.01). Conclusion CT scanning can accurately show changes in the rabbit liver after death. The mean CT value of the liver tissue is more sensitive for inferring early PMI. Furthermore,the liver area/lumbar area ratio parameters are more sensitive for inferring mid-late PMI.

Key words: postmortem interval, forensic pathology, the liver area/lumbar area ratio, liver tissue average CT value

中图分类号: 

  • R89
[1] 赵子琴. 法医病理学[M]. 3版. 北京:人民卫生出版社,2004:38-63.
[2] FLIGNER CL. Review of forensic medicine:fundamentals and perspectives[J]. J Forensic Sci,2015,59(6):1688. DOI:10.1111/1556-4029.12600.
[3] TAKATA T,KITAO T,MIYAISHI S. Relationship between post-mortem interval and creatine concentration in vitreous humour and cerebrospinal fluid[J]. Aust J Forensic Sci,2014,46(2):160-165. DOI:10.1080/00450618.2013.824027.
[4] THALI M. Virtual autopsy (virtopsy) in forensic science[J]. Pathologe,2011,32(2):292-295. DOI:10.1007/s00292-011-1520-5.
[5] 余艳红,赵克森,龚时鹏. 孕兔失血性休克动物模型的建立[J]. 中华围产医学杂志,2007(3):162-165. DOI:10.3760/cma.j.issn.1007-9408.2007.03.005.
[6] GRIMM H. Ethics in laboratory animal science[M]. Vienna:Springer,2014. DOI 10.1007/978-3-7091-1559-6_15.
[7] NABAVI DG,CENIC A,HENDERSON S,et al. Perfusion mapping using computed tomography allows accurate prediction of cerebral infarction in experimental brain ischemia[J]. Stroke,200132(1):175-183. DOI:10.1161/01.STR.32.1.175.
[8] RHEA JT,NOVELLINE RA. How to simplify the CT diagnosis of Le Fort fractures[J]. AJR Am J Roentgenol,2005,184(5):1700-1705. DOI:10.2214/ajr.184.5.01841700.
[9] 杨安峰. 兔的解剖[M]. 北京:科学出版社,1979.
[10] WILLIMAS T,SONI S,WHITE J,et al. Evaluation of DNA degradation using flow cytometry:promising tool for postmortem interval determination[J]. Am J Forensic Med Pathol,2015,36(2):104. DOI:10.1097/PAF.0000000000000146.
[11] PITTNER S,MONTICELLI FC,PFISTERER A,et al. Postmortem degradation of skeletal muscle proteins:a novel approach to determine the time since death[J]. Dtsch Z Gesamte Gerichtl Med,2015,130(2):1-11. DOI:10.1007/s00414-015-1210-6.
[12] 赵伟,张敏,刘旭丹,等. 尸体心血红细胞ATP降解规律与早期死亡时间的相关性[J]. 中国法医学杂志,2014,29(1):1-3. DOI:10.13618/j.issn.1001-5728.2014.01.001.
[13] TAKATA T,KITAO T,MIYAISHI S. Relationship between post-mortem interval and creatine concentration in vitreous humour and cerebrospinal fluid[J]. Aust J Forensic Sci,2014,46(2):160-165. DOI:10.1080/00450618.2013.824027.
[14] COSTA I,CARVALHO F,MAGALHAES T,et al. Promising blood-derived biomarkers for estimation of the postmortem interval[J]. Toxicol Res,2015,4(6):1443-1452. DOI:10.1039/C5TX00209E.
[15] VILLA C,OLSEN K B,HANSEN SH. Virtual animation of victim-specific 3D models obtained from CT scans for forensic reconstructions:living and dead subjects[J]. Forensic Sci Int,2017(278):e27-e33. DOI:10.1016/j.forsciint.2017.06.033.
[16] 肖坚,张会霞,骆昌政,等. 新西兰白兔死亡后颅脑CT检查与死亡时间关系的研究[J]. 中国法医学杂志,2006,21(2):82-84. DOI:10.13618/j.issn.1001-5728.2006.02.007.
[17] BAYAT AR,KOOPMANSCHAP D,KLEIN WM. Postmortem interval estimation:value of postmortem cerebral CT[J]. J Forensic Radio Imaging,2014,2(2):98. DOI:10.1016/j.jofri.2014.02.013.
[18] KOOPMANSCHAP D,BAYAT AR,KUBAT B,et al. The radiodensity of cerebrospinal fluid and vitreous humor as indicator of the time since death[J]. Forensic Sci Med Pathol,2016,12(3):248-256. DOI:10.1007/s12024-016-9778-9.
[19] 吴玉锋,祝志伟,潘莲莲,等. 晚期尸体现象推断死亡时间49例分析[J]. 法医学杂志,2012,28(6):435-437. DOI:10.3969/j.issn.l004-5619.2012.06.009.
[20] WILLEMINK MJ,DAN HARDER AM,DE JONG PA,et al. The future of the CT scan:will CT replace conventional radiography?[J]. Nederlands Tijdschrift Voor Geneeskunde,2014,158:A7438.
[1] 孙溢华, 邢佳鑫, 宣金锋, 姚军, 夏皙, 王保捷. X-STR侧翼序列SNPs在特殊亲缘关系及混合样品鉴定中的意义[J]. 中国医科大学学报, 2018, 47(12): 1072-1076.
[2] 郑吉龙, 倪首涛, 章彪, 巩京慧, 王玖琳, 许高帅. 血痕颜色时序性变化的实验性研究[J]. 中国医科大学学报, 2018, 47(5): 415-419,425.
[3] 邢佳鑫 ,孙溢华,,宣金锋 ,姚军 ,丁梅 ,庞灏 ,李春梅 ,夏皙 ,王保捷. 荧光标记 LDR-PCR 复合扩增方法对高度降解 DNA 检材的SNPs 分型研究[J]. 中国医科大学学报, 2017, 46(8): 703-709.
[4] 杜傲 ,任鹏 ,,何柏林 ,杨顺成 ,丁润涛 ,沈瑞鹏 ,李延柠 ,董志斌 ,卢岩 ,吴旭. 氯胺酮长期滥用后小鼠海马区 caspase-3 和 PSD-95 的表达变化[J]. 中国医科大学学报, 2017, 46(3): 193-196.
[5] 董会,李彩霞,王晶,贾竟,刘超. 一种快速聚合酶链式反应方法的探究和法医学应用[J]. 中国医科大学学报, 2014, 43(10): 931-937.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!

中国医科大学学报版权所有©2018

未经允许,严禁擅自转载本站图文资料

地址:中国 沈阳市沈北新区蒲河路77号 110122

辽ICP备05014850

JOURNAL OF CHINA MEDICAL UNIVERSITY

ADDRESS: NO.77 PUHE ROAD

SHENYANG NORTH NEW AREA, SHENYANG

LIAONING PROVINCE, P.R. CHINA