中国医科大学学报

中国医科大学学报
  • 中文核心期刊
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (3): 222-225.doi: 10.12007/j.issn.0258-4646.2018.03.007

• 论著 • 上一篇    下一篇

小细胞肺癌中DBC1的表达及预后相关性研究

张苏宁, 刘宗昂   

  1. 中国医科大学附属盛京医院胸外科, 沈阳 110004
  • 收稿日期:2017-07-11 出版日期:2018-03-30 发布日期:2018-03-24
  • 通讯作者: 张苏宁 E-mail:zhangsn@sj-hospital.org
  • 作者简介:张苏宁(1964-),男,副教授,博士.
  • 基金资助:
    辽宁省自然科学基金(LFWK201708)

Expression of DBC1 in Small Cell Lung Cancer Tissues and Correlation with Prognosis

ZHANG Suning, LIU Zongang   

  1. Department of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, China
  • Received:2017-07-11 Online:2018-03-30 Published:2018-03-24

摘要: 目的 探讨乳腺癌缺失基因1(DBC1)在可手术的小细胞肺癌组织中的表达情况及其与预后的相关性。方法 回顾性分析中国医科大学附属盛京医院2009年12月至2013年6月行手术治疗的73例小细胞肺癌患者的临床资料。采用定量RT-PCR检测上述病例肺癌标本中DBC1的表达水平,分析DBC1表达水平与各临床病理参数及小细胞肺癌生存的相关性,并用Cox风险比例模型分析预后的独立影响因素。结果 DBC1表达水平与复发转移情况相关(P < 0.05),与患者的性别、年龄、病理类型、分期及吸烟史无明显相关,生存分析显示DBC1高表达组生存期明显低于低表达组(P < 0.01),Cox风险比例模型分析显示DBC1表达可作为小细胞肺癌患者预后的独立影响因素。结论 DBC1高表达与小细胞肺癌复发转移相关,可提示小细胞肺癌患者预后不良。

关键词: 乳腺癌缺失基因1, 小细胞肺癌, 复发转移, 预后

Abstract: Objective To investigate the expression of deleted in breast cancer 1 (DBC1) in small cell lung cancer (SCLC) and its correlation with prognosis. Methods The clinical data of 73 SCLC patients who underwent surgery in Shengjing Hospital of China Medical University between December 2009 and June 2013 were retrospectively analyzed. The expression levels of DBC1 in lung cancer tissues were detected using quantitative real-time polymerase chain reaction (RT-PCR). The correlation between the expression of DBC1 and the clinicopathological parameters of SCLC patients were analyzed. The Kaplan-Meier method was used to analyze the relationship between DBC1 expression and survival of the SCLC patients;independent factors of prognosis were analyzed using the Cox proportional hazards model. Results The expression of DBC1 was significantly associated with recurrence and metastasis (P < 0.05),whereas it was not significant correlated with the patients gender,age,pathological type,stage,and smoking history. Results of the Kaplan-Meier analysis showed that survival rates were significantly decreased in patients with higher DBC1 expression levels when compared to those with lower expression levels (P < 0.01). Cox proportional hazard model analysis showed that the expression of DBC1 can be used as an independent factor for the prognosis of SCLC patients. Conclusion High expression of DBC1 is correlated with recurrence and metastasis of SCLC,and associated with poorer prognosis in SCLC patients.

Key words: deleted in breast cancer-1, small cell lung cancer, recurrence and metastasis, prognosis

中图分类号: 

  • R734.2
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