中国医科大学学报

中国医科大学学报
  • 中文核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
  • BA、CA收录

中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (3): 275-277,281.doi: 10.12007/j.issn.0258-4646.2018.03.019

• 综述 • 上一篇    下一篇

软骨下骨在骨关节炎中的病理改变及其机制

易新1, 周青2, 李波1   

  1. 1. 中国医科大学附属口腔医院口腔解剖生理学教研室, 沈阳 110002;
    2. 中国医科大学附属口腔医院口腔颌面外科学教研室, 沈阳 110002
  • 收稿日期:2017-06-27 出版日期:2018-03-30 发布日期:2018-03-24
  • 通讯作者: 李波 E-mail:libo919@hotmail.com
  • 作者简介:易新(1982-),女,讲师,博士研究生.
  • 基金资助:
    辽宁省教育厅高校科研计划(L2015574);沈阳市科学技术计划(17-133-6-00)

Role of the Subchondral Bone in Osteoarthritis

YI Xin1, ZHOU Qing2, LI Bo1   

  1. 1. Department of Oral Anatomy and Physiology, School of Stomatology, China Medical University, Shenyang 110002, China;
    2. Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang 110002, China
  • Received:2017-06-27 Online:2018-03-30 Published:2018-03-24

摘要: 近年来,软骨下骨的改变在骨关节炎(OA)发生和发展中的作用得到了公认。软骨下骨已被认为是有潜力的治疗OA的靶点。本文就软骨下骨在OA中的病理改变及其机制的研究进展进行综述,为OA的治疗提供治疗依据。

关键词: 软骨下骨, 骨关节炎, 颞下颌关节

Abstract: Temporomandibular joint osteoarthritis (OA) is the most severe type of temporomandibular joint disorder of the oral and maxillofacial region. This disorder has a high incidence,and its main characteristic is articular cartilage injury,accompanied by changes in the synovium and subchondral bone. The role of the changes in the subchondral bone in the development and progression of OA has attracted attention in recent years,and the importance of the subchondral bone has been recognized. At present,the subchondral bone has been considered a promising target for the treatment of OA. This manuscript summarizes the research progress in the pathological changes of the cartilage bone in OA,and its mechanism,which would be helpful for the treatment of this disease.

Key words: subchondral bone, osteoarthritis, temporomandibular joint

中图分类号: 

  • R782.6
[1] CHEN D,SHEN J,ZHAO W,et al.Osteoarthritis:toward a comprehensive understanding of pathologicalmechanism[J]. Bone Res,2017,5:16044. DOI:10.1038/boneres.2016.44.
[2] WANG XD,ZHANG JN,GAN YH,et al. Current understanding of pathogenesis and treatment of TMJ osteoarthritis[J]. J Dent Res,2015,94(5):666-6673. DOI:10.1177/0022034515574770.
[3] PARK DY,JIN LH,MIN BH,et al. Subchondral bone scan uptake correlates with articular cartilage degeneration in osteoarthritic knees[J]. Int J Rheum Dis,2016,20(10):1393-1402. DOI:10.1111/1756-185X.12909.
[4] 孟娟红,甘业华,马绪臣. 颞下颌关节骨关节炎发病的分子机制及相关治疗的实验研究[J]. 北京大学学报(医学版),2013,45(1):5-8. DOI:10.3969/j.issn.1671-167X.2013.01.002.
[5] LIU J,DAI J,WANG Y,et al. Significance of new blood vessels in the pathogenesis of temporomandibular joint osteoarthritis[J]. Exp Ther Med,2017,13(5):2325-2331. DOI:10.3892/etm.2017.4234.
[6] CASTAÑEDA S,ROMAN-BLAS JA,LARGO R,et al. Subchondral bone as a key target for osteoarthritis treatment[J]. Biochem Pharmacol,2012,83(3):315-323. DOI:10.1016/j.bcp.2011.09.018.
[7] GOLDRING M,GOLDRING S. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis[J]. Ann NY Acad Sci,2010,1192(1):230-237. DOI:10.1111/j.1749-6632.2009.05240.x.
[8] MILZ S,PUTZ R.Quantitative morphology of the subchondral plate of thetibial plateau[J]. J Anat,1994,185(Pt 1):103-110.
[9] 许跃,陈扬熙.颞下颌关节软骨下骨改建[J]. 国际口腔医学杂志,2008,35(1):51-53.
[10] SURI S,WALSH DA. Osteochondral alterations in osteoarthritis[J]. Bone,2012,51(2):204-211. DOI:10.1016/j.bone.2011.10.010.
[11] Li G,Yin J,Gao J,et al. Subchondral bone in osteoarthritis:insight into risk factors andmicrostructural changes[J]. Arthritis Res Ther,2013,15(6):223.DOI:10.1186/ar4405.
[12] CASTANEDA S,ROMAN-BLAS JA,LARGO R,et al. Subchondral bone as a key target for osteoarthritis treatment[J]. Biochem Pharmacol,2012,83(3):315-323. DOI:10.1016/j.bcp.2011.09.018.
[13] FOWLER TW,ACEVEDO C,MAZUR CM,et al. Glucocorticoid suppression of osteocyte perilacunar remodeling is associatedwith subchondral bone degeneration in osteonecrosis[J]. Sci Rep,2017,22(7):44618. DOI:10.1038/srep44618.
[14] 杜明昌,祖启明,刘宪民,等.软骨下骨病理骨重建过程中骨细胞的代谢机制[J]. 中国组织工程研究与临床康复,2011,15(37):6995-6999. DOI:10.3969/j.issn.1673-8225.2011.37.037.
[15] LAJEUNESSE D,REBOUL P. Subchondral bone in osteoarthritis:a biologic link with articular cartilage leading to abnormal remodeling[J]. Curr Opin Rheumatol,2003,15(5):628-633. DOI:10.1097/00002281-200309000-00018.
[16] MARUOTTI N,CORRADO A,CANTATORE FP. Osteoblast role in osteoarthritis pathogenesis[J]. J Cell Physiol,2017,232(11):2957-2963. DOI:10.1002/jcp.25969.
[17] FINDLAY DM,ATKINS GJ. Osteoblast-chondrocyte interactions in osteoarthritis[J]. Curr Osteoporosis Reports,2014,12(1):127-134. DOI:10.1007/s11914-014-0192-5.
[18] Burr DB,Gallant MA. Bone remodeling in osteoarthritis[J]. Nat Rev Rheumatol,2012,8(11):665-673. DOI:10.1038/nrrheum.2012.130.
[19] FAZZALARI N,PARKINSON IH. Fractal properties of subchondral cancellous bone in severe osteoarthritis of the hip[J]. J Bone Miner Res,1997,12(4):632-640. DOI:10.1359/jbmr.1997.12.4.632.
[20] BARR AJ,CAMPBELL TM,HOPKINSON D,et al. A systematic review of the relationship between subchondral bone features,pain and structural pathology in peripheral joint osteoarthritis[J]. Arthritis Res Ther,2015,17(1):228. DOI:10.1186/s13075-015-0735-x.
[21] Pritzker KP,Gay S,Jimenez SA,et al. Osteoarthritis cartilage histopathology:grading and staging[J]. Osteoarthritis Cartilage,2006,14(1):13-29. DOI:10.1016/j.joca.2005.07.014.
[22] NAKASA T,ADACHI N,KATO T,et al. Correlation between subchondral bone plate thickness and cartilage degeneration in osteoarthritis of the ankle[J].Foot Ankle Int,2014,35(12):1341-1349. DOI:10.1177/1071100714548061.
[23] PARK DY,JIN LH,MIN BH,et al. Subchondral bone scan uptake correlates with articular cartilage degeneration in osteoarthritic knees[J]. Int J Rheum Dis,2017,20(10):1393-1402. DOI:10.1111/1756-185X.12909.
[24] FINNILÄ MAJ,THEVENOT J,AHO OM,et al. Association between subchondral bone structure and osteoarthritis histopathological grade[J]. J Orthop Res,2017,35(4):785-792. DOI:10.1002/jor.23312.
[25] AHO OM,FINNILÄ M,THEVENOT J,et al. Subchondral bone histology and grading in osteoarthritis[J]. PLoS One,2017,12(3):e0173726. DOI:10.1371/journal.pone.0173726.
[26] WANG J,GARDNER B,LU Q,et al. Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes[J]. J Pathol,2009,219(2):163-172. DOI:10.1002/path.2578.
[27] LEYH M,SEITZ A,DÜRSELEN L,et al. Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes[J]. Arthritis Res Ther,2014,16(5):453. DOI:10.1186/s13075-014-0453-9.
[28] Janssens K,ten Dijke P,Janssens S,et al. Transforming growth factor-beta 1 to the bone[J]. Endocr Rev,2005,26(6):743-774. DOI:10.1210/er.2004-0001.
[29] ZHAO WW,WANG T,LUO Q,et al. Cartilage degeneration and excessive subchondral bone formationin spontaneous osteoarthritis involves altered TGF-β signaling[J]. J Orthop Res,2016,34(5):763-770. DOI:10.1002/jor.23079.
[30] RE'EM T,WITTE F,WILLBOLD E,et al. Simultaneous regeneration of articular cartilage and subchondral bone induced by spatially presented TGF-beta and BMP-4 in a bilayer affinity bindingsystem[J]. Acta Biomater,2012,8(9):3283-3293. DOI:10.1016/j.actbio.2012.05.014.
[31] ZHEN GH,CAO X. Targeting TGF-β signaling insubchondral bone and articular cartilage homeostasis[J].Trends Pharmacolo Sci,2014,35(5):227-236. DOI:10.1016/j.tips.2014.03.005.
[32] XU X,ZHENG LW,BIAN Q. Aberrant activation of TGF-β in subchondral bone at the onset of rheumatoid arthritis joint destruction[J]. J Bone Mineral Res,2015,30(11):2033-2043. DOI:10.1002/jbmr.2550.
[33] ZHEN G,WEN C,JIA X,et al. Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis[J]. Nat Med,2013,19(6):704-712. DOI:10.1038/nm.3143.
[34] 汪听亚,裘敏蕾,樊天佑.软骨下骨在骨关节炎发病机制中的研究进展[J]. 中国骨与关节杂志,2016,5(2):149-153. DOI:10.3969/j.issn.2095-252X.
[35] 刘晓东,张勉,王美青.咬合紊乱导致颞下颌关节髁突异常改建[J].中国实用口腔科杂志,2017,10(6):335-339. DOI:10.19538/j.kq.2017.06.004.
[36] RHEE SH,BAEK GH. A correlation exists between subchondral bone mineral density of the distal radius and systemic bone mineral density[J]. Clin Orthop Relat Res,2012,470(6):1682-1689. DOI:10.1007/s11999-011-2168-4.
[37] SUN YB,SCANNELL BP,HONEYCUTT PR,et al. cartilage degeneration,subchondral mineral and meniscal mineral densities in hartley and strain 13 guinea pigs[J]. Open Rheumatol J,2015,9(1):65-70. DOI:10.2174/1874312901409010065.
[1] 刘一秀,阿良,刘哲. 关节腔清理术联合透明质酸钠关节腔内注射治疗早中期膝骨关节炎的疗效分析[J]. 中国医科大学学报, 2017, 46(2): 179-180.
[2] 唐涛 ,,张继虹 ,孙先润 ,李治 ,王波 ,刘颖 ,李亚国 ,肖壮 ,李连娥 ,李晓云. 绿色荧光蛋白滑膜间充质干细胞抑制大鼠骨关节炎的实验研究[J]. 中国医科大学学报, 2016, 45(10): 913-917.
[3] 潘贤峰, 杨鑫斌, 段培青, 张榕, 肖卫国. 补肾活血方对家兔骨关节炎滑液中IL-6和MMP-13表达的影响[J]. 中国医科大学学报, 2015, 44(10): 909-912.
[4] 蔡琳,王晓非,郭韵,张晓莉,蒋莉,赵海燕. 血清Survivin在关节炎中的变化及其临床相关性的研究[J]. 中国医科大学学报, 2013, 42(10): 907-910.
[5] 李波,卢利,谭学新,刘纯义,易新,刘焱. 代谢型谷氨酸受体5在大鼠颞下颌关节疼痛中的作用研究[J]. 中国医科大学学报, 2012, 41(10): 912-914.
[6] 杨礼庆,付勤,李希. 人工全肘关节置换术1例报告[J]. 中国医科大学学报, 2012, 41(1): 93-93.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!

中国医科大学学报版权所有©2018

未经允许,严禁擅自转载本站图文资料

地址:中国 沈阳市沈北新区蒲河路77号 110122

辽ICP备05014850

JOURNAL OF CHINA MEDICAL UNIVERSITY

ADDRESS: NO.77 PUHE ROAD

SHENYANG NORTH NEW AREA, SHENYANG

LIAONING PROVINCE, P.R. CHINA