中国医科大学学报

中国医科大学学报
  • 中文核心期刊
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (4): 350-354.doi: 10.12007/j.issn.0258-4646.2018.04.014

• 论著 • 上一篇    下一篇

反复移植失败患者子宫内膜容受性的超声评价

张倩, 李芷舒, 张宇明, 王英华, 白璐, 鲁海鸥, 于月新   

  1. 解放军第202医院生殖医学中心, 沈阳 110003
  • 收稿日期:2017-04-24 出版日期:2018-04-30 发布日期:2018-04-10
  • 通讯作者: 于月新 E-mail:yuyuexinpingan@163.com
  • 作者简介:张倩(1989-),女,医师,硕士.

Role of Color Doppler Ultrasound in Recurrent Implantation Failure

ZHANG Qian, LI Zhishu, ZHANG Yuming, WANG Yinghua, BAI Lu, LU Haiou, YU Yuexin   

  1. Reproductive Medicine Center, No. 202 Hospital of China People's Liberation Army, Shenyang 110003, China
  • Received:2017-04-24 Online:2018-04-30 Published:2018-04-10

摘要: 目的 探讨超声评估反复移植失败(RIF)患者子宫内膜容受性的特点。方法 选取2014年6月至2016年11月于解放军第202医院生殖医学中心行体外受精/卵泡浆内单精子注射-胚胎移植(IVF/ICSI-ET)治疗的RIF患者(RIF组,n=40),同期IVF/ICSI-ET治疗助孕成功患者(妊娠组,n=104)为对照组,对研究对象进行回顾性分析。所有患者均为冻融胚胎移植,于移植日行经阴道彩色多普勒超声检查,测量子宫内膜容受性相关参数。比较2组间各参数的差异。结果 RIF组患者子宫动脉及子宫内膜螺旋动脉的阻力指数(RI)均高于妊娠组,体质量指数(BMI)低于妊娠组,差异均有统计学意义(P < 0.05)。2组间子宫内膜厚度和形态、子宫动脉及子宫内膜螺旋动脉的搏动指数(PI)、收缩期峰值血流速度与舒张末期血流速度的比值(S/D)以及子宫内膜蠕动波蠕动频率无统计学差异(P > 0.05)。结论 超声测定子宫动脉及子宫内膜螺旋动脉的RI值有助于评价子宫内膜容受性,子宫血供和容受性下降可能与RIF的发生具有相关性。

关键词: 彩色多普勒超声, 子宫内膜容受性, 反复移植失败, 体外受精-胚胎移植

Abstract: Objective To investigate the characteristics of endometrial receptivity in patients with repeated implantation failure (RIF) using color Doppler ultrasound. Methods Between June 2014 and November 2016,40 RIF patients and 104 infertility patients who become pregnant with in vitro fertilization-embryo transfer technology in the Reproductive Medicine Center of No. 202 Hospital of PLA were analyzed retrospectively. All patients underwent frozen embryo transfer. Parameters related to endometrial receptivity were examined with transvaginal Doppler on the embryo transfer day and differences between the two groups were compared. Results Resistance index (RI) values in the uterine artery and uterine spiral artery were higher in RIF patients than in pregnant patients,but body mass index was lower. There were statistically significant differences between the two groups (P < 0.05). However,no difference was found in endometrial thickness,uterine artery pulsatility index (PI),uterine spiral artery PI,systolic/diastolic ratio,or uterine peristalsis between the two groups (P > 0.05). Conclusion Measurements of RI in the uterine artery and uterine spiral artery are useful in evaluation of endometrial receptivity. Uterine artery and descending endometrial receptivity may have a positive correlation in patients with recurrent implantation failure following in vitro fertilization-embryo transfer.

Key words: color Doppler ultrasound, endometrial receptivity, recurrent implantation failure, in vitro fertilization-embryo transfer

中图分类号: 

  • R711.6
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