中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (5): 448-453.doi: 10.12007/j.issn.0258-4646.2018.05.015

• 论著 • 上一篇    下一篇

癌组织中CD45RO表达水平与肺腺癌患者临床病理特征及生存率的关联分析

俞达辉, 吴道立, 袁冲, 褚文炎   

  1. 余姚市人民医院心胸外科, 浙江 余姚 315400
  • 收稿日期:2017-04-20 出版日期:2018-05-30 发布日期:2018-04-27
  • 通讯作者: 褚文炎 E-mail:chuwenyan@163.com
  • 作者简介:俞达辉(1981-),男,主治医师,硕士.

Correlation of Tissue CD45RO with the Clinicopathological Properties and Prognosis in Surgical Patients with Lung Adenocarcinoma

YU Dahui, WU Daoli, YUAN Chong, CHU Wenyan   

  1. Department of Cardiothoracic Surgery, Yuyao People's Hospital, Yuyao 315400, China
  • Received:2017-04-20 Online:2018-05-30 Published:2018-04-27

摘要: 目的 评估肿瘤组织CD45RO表达水平与肺腺癌手术患者的临床病理参数及预后的相关性。方法 选取121例进行手术的肺腺癌患者,采集肿瘤组织和癌旁组织样本。采用anti-CD45RO抗体进行免疫组织化学染色检测CD45RO表达水平,计算染色强度分数和染色面积分数的乘积得到总表达评分,并分为高、中和低表达。结果 相对于癌旁组织,CD45RO在肺腺癌组织中高表达;肿瘤组织CD45RO表达水平与肿瘤大小、淋巴结转移呈负相关;Kaplan-Meier (K-M)曲线显示,肺腺癌组织中的CD45RO表达水平越高,无病生存期(DFS)和总体生存期(OS)越长;多因素COX回归发现,肺腺癌组织CD45RO表达量能独立预测良好的DFS,然而,低分化和淋巴结转移均能独立预测不良的DFS;肺腺癌组织CD45RO表达量是较长OS的独立预测因素,而低分化、淋巴转移及远端转移均是OS的独立危险因素。结论 肿瘤组织中CD45RO的表达水平可作为新的、可靠的生物标记物,用于评估肺腺癌手术患者的临床病理特征和预后情况。

关键词: 肺腺癌组织, CD45RO, 临床病理特征, 预后, 肺腺癌手术患者

Abstract: Objective To evaluate the association between tumor tissue CD45RO expression and the clinicopathological properties and prognoses in surgical patients with lung adenocarcinoma (LAC).Methods One hundred and twenty-one patients with LAC were recruited for the study. LAC tissues and paired adjacent LAC tissue samples were collected. CD45RO expression was evaluated based on immunohistochemistry.Results CD45RO expression was higher in tumor tissue samples than in paired adjacent LAC tissue samples. Tumor tissue CD45RO expression was positively associated with tumor size but was negatively associated with lymph node metastasis (LYM). Kaplan-Meier curves revealed that high tumor tissue CD45RO expression was correlated with better disease-free survival (DFS) and overall survival (OS) compared to those of low tumor tissue CD45RO expression. Univariate COX regression indicated that high tumor tissue CD45RO expression predicted prolonged DFS,while poor differentiation,LYM,and tumor-node-metastasis (TNM) stage predicted worse DFS. Multivariate COX regression revealed that high tumor tissue CD45RO expression was an independent protective factor of DFS,while poor differentiation and LYM acted as independent risk factors of DFS. Furthermore,univariate analysis indicated that high tumor tissue CD45RO expression predicted prolonged OS,while poor differentiation,LYM,distant metastases,and TNM stage predicted worse OS. Multivariate analysis revealed that poor differentiation,LYM,and distant metastases acted as independent risk factors of shorter OS.Conclusion CD45RO expression could serve as a novel and convincing prognostic biomarker in surgical patients with LAC.

Key words: tumor tissue, CD45RO, clinicopathological, prognosis, lung adenocarcinoma

中图分类号: 

  • R734.2
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