中国医科大学学报

中国医科大学学报
  • 中文核心期刊
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (7): 593-596,600.doi: 10.12007/j.issn.0258-4646.2018.07.005

• 论著 • 上一篇    下一篇

miR-497-5p在子宫内膜病变组织中的表达及临床意义

孔繁菲, 马剑, 丛蓉, 杨慧, 冷洪锐, 马晓欣   

  1. 中国医科大学附属盛京医院妇产科, 沈阳 110022
  • 收稿日期:2018-02-23 出版日期:2018-07-30 发布日期:2018-07-03
  • 通讯作者: 马晓欣 E-mail:maxiaoxin666@aliyun.com
  • 作者简介:孔繁菲(1989-),女,博士研究生.
  • 基金资助:
    国家自然科学基金(81472438);盛京自由研究者基金(201601);盛京医院优秀课题基金(ME40)

Expression of miR-497-5p in Endometrial Lesions and Its Clinical Significance

KONG Fanfei, MA Jian, CONG Rong, YANG Hui, LENG Hongrui, MA Xiaoxin   

  1. Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang 110022, China
  • Received:2018-02-23 Online:2018-07-30 Published:2018-07-03

摘要: 目的 检测miR-497-5p在不同子宫内膜病变组织中的表达,探讨与子宫内膜癌临床病理参数的关系及其临床意义。方法 采用原位杂交法检测110例子宫内膜癌、20例非典型增生及30例正常子宫内膜组织中miR-497-5p的表达。结果 子宫内膜癌及非典型增生子宫内膜组织中,miR-497-5p的阳性表达率均低于正常内膜组织,其表达强度与临床分期(P < 0.001)、分化级别(P < 0.001)、肿瘤浸润深度(P=0.039)和淋巴结转移(P=0.022)有关。利用癌症和肿瘤基因图谱数据库中数据进行生存分析,提示miR-497-5p高表达组子宫内膜癌患者预后更佳(P < 0.05)。结论 miR-497-5p在子宫内膜癌组织中的表达水平明显降低,可作为判断子宫内膜癌患者预后的指标之一。

关键词: 子宫内膜癌, miR-497-5p, 原位杂交

Abstract: Objective To investigate miR-497-5p expression in different endometrial lesions, determine its relationship with clinicopathological parameters, and explore its clinical significance. Methods miR-497-5p expression in 110 cases of endometrial carcinoma, 20 cases of atypical endometrial hyperplasia, and 30 normal endometria was detected by in situ hybridization. Results The frequency of positive miR-497-5p expression was lower in endometrial carcinoma and atypical hyperplasia than in normal endometrial tissues. miR-497-5p expression was associated with the clinical stage(P < 0.001), differentiation level(P < 0.001), tumor invasion depth(P=0.039), and lymph node metastasis(P=0.022). Survival analysis conducted on data from the TCGA database revealed a better prognosis of patients with endometrial cancer overexpressing miR-497-5p(P < 0.05). Conclusion miR-497-5p expression is significantly decreased in endometrial carcinoma tissues, indicating its utility as a prognostic marker in patients with endometrial cancer.

Key words: endometrial carcinoma, miR-497-5p, in situ hybridization

中图分类号: 

  • R34
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