中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (7): 604-608.doi: 10.12007/j.issn.0258-4646.2018.07.008

• 论著 • 上一篇    下一篇

结直肠癌患者围手术期肠内外联合营养支持与预后的关系

马艳梅, 常箫匀   

  1. 锦州医科大学附属第一医院护理部, 辽宁 锦州 121001
  • 收稿日期:2017-04-19 出版日期:2018-07-30 发布日期:2018-07-03
  • 通讯作者: 马艳梅 E-mail:qwer7849@163.com
  • 作者简介:马艳梅(1971-),女,副主任护师,硕士.
  • 基金资助:
    辽宁省自然科学基金(2015020350)

Relationship between Perioperative Enteral Nutrition and Prognosis in Patients with Colorectal Cancer

MA Yanmei, CHANG Xiaoyun   

  1. Department of Nursing, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China
  • Received:2017-04-19 Online:2018-07-30 Published:2018-07-03

摘要: 目的 探讨结直肠癌患者围手术期肠内外联合营养支持与预后的关系。方法 选取2015年1月至12月于锦州医科大学附属第一医院手术切除的结直肠癌患者159例,随机分为肠内营养(EN)组、肠外营养(PN)组与肠内外联合营养(EN+PN)组。分析预后相关营养指标、临床指标、免疫指标及疲劳指数的关系。结果 EN+PN组前白蛋白、转铁蛋白、白蛋白明显高于EN组和PN组(P < 0.05);3组术后第1次排气时间、第1次排便时间、住院时间、所需营养费用、并发症发生率差异具有统计学意义(P < 0.05);EN组、EN+PN组患者术后CD3+、CD4+、CD4+/CD8+均高于术前(P < 0.05);3组术后血清免疫球蛋白IgG、IgA、IgM水平均高于术前(P < 0.05);3组疲劳指数差异具有统计学意义(P < 0.05)。结论 结直肠癌患者围手术期肠内外联合营养支持是合理的个体化营养支持方案,值得临床推广。

关键词: 联合营养支持, 结直肠癌, 预后, 围手术期

Abstract: Objective To investigate the relationship between perioperative enteral nutrition and colorectal cancer in patients with colorectal cancer. Methods Prognostic factors and prognosis-related clinical indicators were analyzed with respect to perioperative enteral nutrition, colorectal cancer, and immune system fatigue index. Results The values of pre-albumin (PA), transferrin (TF), and albumin(ALB) in the enteral nutrition(EN)+parenteral nutrition(PN)group were significantly higher than those in the EN and PN groups (P < 0.05). The differences in first exhaustion time, first defecation time, hospitalization time, required nutritional expenses, and complication rate were statistically significant(P < 0.05). The levels of CD3+, CD4+, and CD4+/CD8+in the EN and EN+PN groups were higher than those before surgery(P < 0.05). The levels of serum immunoglobulin IgG, IgA, and IgM in all three groups were significantly higher than those before surgery(P < 0.05). The differences in fatigue index among the three groups were statistically significant(P < 0.05). Conclusion Perioperative enteral nutrition support is an appropriate nutritional support program.

Key words: joint nutrition support, colorectal cancer, prognosis, perioperative period

中图分类号: 

  • R656.9
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