中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (10): 929-932,938.doi: 10.12007/j.issn.0258-4646.2018.10.015

• 论著 • 上一篇    下一篇

中国5市育龄妇女微小病毒B19流行病学调查

齐莹1, 王博1, 谭美玉2, 朱海燕3, 李荣4, 岳化葵5, 盛慧明2, 骆建云4, 阮强1   

  1. 1. 中国医科大学附属盛京医院病毒室, 沈阳 110004;
    2. 上海交通大学医学院附属同仁医院检验科, 上海 200336;
    3. 中国人民解放军海军总医院妇产科, 北京 100048;
    4. 重庆医科大学附属第一医院妇产科, 重庆 630014;
    5. 深圳市人民医院检验科, 广东深圳 518001
  • 收稿日期:2017-09-08 出版日期:2018-10-30 发布日期:2018-09-30
  • 通讯作者: 阮强 E-mail:ruanq@sj-hospital.org
  • 作者简介:齐莹(1975-),女,副教授,博士.

Seroprevalence of Human Parvovirus B19 among Reproductive-aged Women from Five Different Areas of China

QI Ying1, WANG Bo1, TAN Meiyu2, ZHU Haiyan3, LI Rong4, YUE Huakui5, SHENG Huiming2, LUO Jianyun4, RUAN Qiang1   

  1. 1. Virus Laboratory, Shengjing Hospital, China Medical University, Shenyang 110004, China;
    2. Department of Clinical Laboratory, Tongren Hospital, Shanghai Jiao Tong University, Shanghai 200336, China;
    3. Department of Gynaecology and Obstetrics, Navy General Hospital, Beijing 100048, China;
    4. Department of Gynaecology and Obstetrics, The First Hospital of Chongqing Medical University, Chongqing 630014, China;
    5. Department of Clinical Laboratory, Shenzhen People's Hospital, Shenzhen 518001, China
  • Received:2017-09-08 Online:2018-10-30 Published:2018-09-30

摘要: 目的 通过检测微小病毒B19(简称B19病毒)IgM和IgG抗体,评估B19病毒在我国不同地区育龄妇女中的流行情况。方法 采用全自动化学发光免疫分析法检测2016年7月至12月来自北京、重庆、上海、深圳以及沈阳5座不同城市5家医院的1 401名育龄妇女(18~42岁)血清标本中的B19病毒IgM和IgG抗体水平。结果 B19病毒IgM抗体的阳性率为0.36%(5/1 401),IgG抗体的阳性率为15.20%(213/1 401)。孕前、孕早、中及晚期育龄妇女B19病毒IgG抗体阳性率依次为16.92%、15.49%、14.79%及14.59%,差异无统计学意义(P > 0.05)。在北京、重庆、上海、深圳及沈阳B19病毒IgG抗体阳性率分别为23.97%,18.90%,17.85%,13.88%及10.18%,有统计学差异(P < 0.01)。未发现学龄前和学龄儿童的母亲、幼儿园保育员以及学校教师等与婴幼儿和儿童密切接触人群具有更高的B19病毒既往感染率(P > 0.05)。结论 中国不同地域B19病毒既往感染率存在明显差异;约85%的中国育龄妇女是B19病毒的易感者,约0.36%为急性感染者,其危害应该引起高度重视。

关键词: 人微小病毒B19, 血清阳性率, 育龄妇女

Abstract: Objective To assess the seroprevalence of human parvovirus B19 among reproductive-aged women from different areas of China. Methods In total,1 401 women (aged 18-42 years)from five cities in China were included in the study. Specific IgG and IgM antibodies for human parvovirus B19 detected in the women were measured using LIAISON® Biotrin Parvovirus B19 Chemiluminescence Immunoassay,from July to December 2016. Results The rate of positive IgM antibodies for parvovirus B19 in the studied population was 0.36% (5/1 401)and that of positive IgG antibodies was 15.20% (213/1 401). The rates of IgG-positive antibodies for parvovirus B19 before pregnancy,and during early,mid-,and late pregnancy were 16.92%,15.49%,14.79%,and 14.59%,respectively. The distribution of women with IgG-positive antibodies for parvovirus B19 in the different stages of pregnancy did not differ statistically (P > 0.05). The rates of IgG-positive antibodies for parvovirus B19 in women from Beijing,Chongqing,Shanghai,Shenzhen,and Shenyang were 23.97%, 18.90%,17.85%,13.88%,and 10.18%,respectively,and the difference was statistically significant (P < 0.01). In addition,there was no association between past infection with parvovirus B19 and close contact with young children (P > 0.05). Conclusion The rates of past infection with parvovirus B19 significantly differed among the different Chinese provinces. Approximately 0.36% of reproductive-aged women in China were observed to have acute infection,and approximately 85% of the women were susceptible to primary parvovirus B19 infection,which could adversely affect their pregnancy. Hence,careful attention must be paid to reproductive-aged women with parvovirus B19 infection.

Key words: human parvovirus B19, seroprevalence, reproductive-aged women

中图分类号: 

  • R373.9
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