中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (10): 939-941,947.doi: 10.12007/j.issn.0258-4646.2018.10.017

• 综述 • 上一篇    下一篇

间充质干细胞外泌体免疫调节作用及其机制的研究进展

余思, 刘尧, 陈旭   

  1. 中国医科大学口腔医学院儿童口腔科, 辽宁省口腔疾病重点实验室, 沈阳 110002
  • 收稿日期:2018-01-15 出版日期:2018-10-30 发布日期:2018-09-30
  • 通讯作者: 陈旭 E-mail:chenxu@cmu.edu.cn
  • 作者简介:余思(1992-),女,硕士研究生.
  • 基金资助:
    国家自然科学基金(81771059);辽宁省自然科学基金(201602842)

The Immunomodulatory Properties and Underlying Mechanisms of Exosomes Derived from Mesenchymal Stem Cells

YU Si, LIU Yao, CHEN Xu   

  1. Department of Pediatric Dentistry, School of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease, Shenyang 110002, China
  • Received:2018-01-15 Online:2018-10-30 Published:2018-09-30

摘要: 外泌体是一类由真核细胞分泌的细胞外微囊泡,能够介导细胞之间的信息交流。间充质干细胞(MSCs)外泌体具有和MSCs相似的生物学功能,在修复组织损伤、抑制局部炎症和调节免疫中发挥重要作用。与MSCs相比,外泌体更稳定而且易保存,免疫排斥反应的风险较低,为多种疾病的细胞治疗提供了新选择。本文将对MSCs外泌体免疫调节作用及其机制的研究进展做一综述。

关键词: 间充质干细胞, 外泌体, 免疫调节

Abstract: Exosomes are a type of extracellular microvesicles that can be released by multiple nuclear cells. The functions of exosomes derived from mesenchymal stem cells (MSCs)are similar to those of MSCs. Moreover,exosomes play an important role in repairing tissue damage,suppressing local inflammatory responses,and modulating the immune system. Compared with the whole cell,exosomes are more stable and easier to store;furthermore,they have a lower risk of immune rejection. Therefore,they can serve as a novel agent for cell therapy of many diseases. In this paper,the immunomodulatory properties and underlying mechanisms of exosomes derived from MSCs are reviewed.

Key words: mesenchymal stem cells, exosomes, immunmodulation

中图分类号: 

  • R329.2
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