中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (11): 1032-1035.doi: 10.12007/j.issn.0258-4646.2018.11.017

• 综述 • 上一篇    下一篇

疟原虫和血吸虫混合感染免疫机制研究进展

李英桐1, 王佳琦1, 王祝宁1, 王美莲2   

  1. 1. 中国医科大学临床医学二系, 沈阳 110122;
    2. 中国医科大学基础医学院病原生物学教研室, 沈阳 110122
  • 收稿日期:2018-03-11 出版日期:2018-11-30 发布日期:2018-12-06
  • 通讯作者: 王美莲 E-mail:wangmeilian_m@hotmail.com
  • 作者简介:李英桐(1997-),女,本科在读.
  • 基金资助:
    国家自然科学基金青年基金(81501769);中国医科大学大学生创新项目(201710159000164)

Immunological Mechanisms of Coinfection with Plasmodium and Schistosoma

LI Yingtong1, WANG Jiaqi1, WANG Zhuning1, WANG Meilian2   

  1. 1. The Second Department of Clinical Medicine, China Medical University, Shenyang 110122, China;
    2. Department of Pathogenic Biology, College of Basic Medical Science, China Medical University, Shenyang 110122, China
  • Received:2018-03-11 Online:2018-11-30 Published:2018-12-06

摘要: 疟原虫和血吸虫混合感染十分常见,但混合感染如何影响机体的免疫应答仍有争议。血吸虫与疟原虫混合感染可避免脑疟疾的发生发展,并可降低原虫血症水平,减轻肝、脾等脏器的病理反应等,因而产生有利作用;血吸虫感染后加重了疟原虫对机体的潜在威胁(增加原虫血症、加重病理反应、加重机体损害等)。本文就血吸虫和疟原虫混合感染免疫机制相关研究进行综述。

关键词: 疟原虫, 血吸虫, 混合感染, 免疫机制

Abstract: Plasmodium and schistosoma coinfection is common,but how it affects the immune response of the body is still controversial. Coinfection with plasmodium and schistosoma can prevent cerebral malaria occurrence and development,decrease the parasite disease levels,reduce visceral pathological reactions such as those in the liver and spleen,and thus plays an important role. However,schistosoma infection has increased the potential threat of plasmodium to the body (increasing the risk of parasitemia,aggravating the pathological reaction,and exacerbating the damage to the body). The article reviewed related studies on the immunological mechanisms of plasmodium and schistosoma coinfection.

Key words: plasmodium, schistosoma, coinfection, immunological mechanism

中图分类号: 

  • R382.3
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