• 中文核心期刊
  • 中国科技核心期刊
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (11): 1032-1035.doi: 10.12007/j.issn.0258-4646.2018.11.017

• 综述 • 上一篇    下一篇


李英桐1, 王佳琦1, 王祝宁1, 王美莲2   

  1. 1. 中国医科大学临床医学二系, 沈阳 110122;
    2. 中国医科大学基础医学院病原生物学教研室, 沈阳 110122
  • 收稿日期:2018-03-11 出版日期:2018-11-30 发布日期:2018-12-06
  • 通讯作者: 王美莲
  • 作者简介:李英桐(1997-),女,本科在读.
  • 基金资助:

Immunological Mechanisms of Coinfection with Plasmodium and Schistosoma

LI Yingtong1, WANG Jiaqi1, WANG Zhuning1, WANG Meilian2   

  1. 1. The Second Department of Clinical Medicine, China Medical University, Shenyang 110122, China;
    2. Department of Pathogenic Biology, College of Basic Medical Science, China Medical University, Shenyang 110122, China
  • Received:2018-03-11 Online:2018-11-30 Published:2018-12-06

摘要: 疟原虫和血吸虫混合感染十分常见,但混合感染如何影响机体的免疫应答仍有争议。血吸虫与疟原虫混合感染可避免脑疟疾的发生发展,并可降低原虫血症水平,减轻肝、脾等脏器的病理反应等,因而产生有利作用;血吸虫感染后加重了疟原虫对机体的潜在威胁(增加原虫血症、加重病理反应、加重机体损害等)。本文就血吸虫和疟原虫混合感染免疫机制相关研究进行综述。

关键词: 疟原虫, 血吸虫, 混合感染, 免疫机制

Abstract: Plasmodium and schistosoma coinfection is common,but how it affects the immune response of the body is still controversial. Coinfection with plasmodium and schistosoma can prevent cerebral malaria occurrence and development,decrease the parasite disease levels,reduce visceral pathological reactions such as those in the liver and spleen,and thus plays an important role. However,schistosoma infection has increased the potential threat of plasmodium to the body (increasing the risk of parasitemia,aggravating the pathological reaction,and exacerbating the damage to the body). The article reviewed related studies on the immunological mechanisms of plasmodium and schistosoma coinfection.

Key words: plasmodium, schistosoma, coinfection, immunological mechanism


  • R382.3
[1] LEMAITRE M,WATIER L,BRIAND V,et al. Coinfection with Plasmodium falciparum and Schistosoma haematobium:additional evidence of the protective effect of schistosomiasis on malaria in Senegalese children[J]. Am J Trop Med Hyg,2014,90(2):329-334. DOI:10.4269/ajtmh.12-0431.
[2] DOUMBO S,TRAN TM,SANGALA J,et al. Co-infection of long-term carriers of Plasmodium falciparum with Schistosoma haematobium enhances protection from febrile malaria:a prospective cohort study in Mali[J]. PLoS Negl Trop Dis,2014,8(9):e3154. DOI:10.1371/journal.pntd.0003154.
[3] WANG ML,FENG YH,PANG W,et al. Parasite densities modulate susceptibility of mice to cerebral malaria during co-infection with Schistosoma japonicum and Plasmodium berghei[J]. Malar J,2014,13:116. DOI:10.1186/1475-2875-13-116.
[4] GARCIA LS. Malaria[J]. Clin Lab Med,2010,30(1):93-129. DOI:10.1016/j.cll.2009.10.001
[5] YAM XY,PREISER PR. Host immune evasion strategies of malaria blood stage parasite[J]. Mol Biosyst,2017,13(12):2498-2508.
[6] LI C,SEIXAS E,LANGHORNE J. Rodent malarias:the mouse as a model for understanding immune responses and pathology induced by the erythrocytic stages of the parasite[J]. Med Microbiol Immunol,2001,189(3):115-126.
[7] SHAHABI S,MOHAMMADZADEH HAJIPIRLOO H,KERAMATI A,et al. Evaluation of the adjuvant activity of propranolol,a Beta-adrenergic receptor antagonist,on efficacy of a malaria vaccine model in BALB/c mice[J]. Iran J Allergy Asthma Immunol,2014,13(5):307-316.
[8] SINA BJ,WRIGHT C,ATKINSON CT,et al. Characterization of a sporozoite antigen common to Plasmodium falciparum and Plasmodium berghei[J]. Mol Biochem Parasitol,1995,69(2):239-246.
[9] LAU AO,SACCI JB JR,AZAD AF. Host responses to Plasmodium yoelii hepatic stages:a paradigm in host-parasite interaction[J]. J Immunol,2001,166(3):1945-1950. DOI:10.4049/jimmunol.166.3.1945.
[10] TANIGUCHI T,MD MANNOOR K,NONAKA D,et al. A unique subset of γ δ T cells expands and produces IL-10 in patients with naturally acquired immunity against falciparum malaria[J]. Front Microbiol,2017,8:1288. DOI:10.3389/fmicb.2017.01288.
[11] KARADJIAN G,BERREBI D,DOGNA N,et al. Co-infection restrains litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice[J]. Parasite,2014,21:16. DOI:10.1051/parasite/2014017.
[12] UEFFING K,ABBERGER H,WESTENDORF AM,et al. Conventional CD11chigh dendritic cells are important for T cell priming during the initial phase of Plasmodium yoelii infection,but are dispensable at later time points[J]. Front Immunol,2017,8:1333. DOI:10.3389/fimmu.2017.01333.
[13] KOBAYASHI F,MORⅡ T,MATSUI T,et al. Production of interleukin 10 during malaria caused by lethal and nonlethal variants of Plasmodium yoelii yoelii[J]. Parasitol Res,1996,82(5):385.
[14] KESWANI T,BHATTACHARYYA A. Differential role of T regulatory and Th17 in Swiss mice infected with Plasmodium berghei ANKA and Plasmodium yoelii[J]. Exp Parasitol,2014,141(6):82-92. DOI:10.1016/j.exppara.2014.03.003.
[15] KESWANI T,SARKAR S,SENGUPTA A,et al. Role of TGF-β and IL-6 in dendritic cells,Treg and Th17 mediated immune response during experimental cerebral malaria[J]. Cytokine,2016,88:154-166. DOI:10.1016/j.cyto.2016.08.034.
[16] SOUZA JBD,WILLIAMSON KH,OTANI T,et al. Early gamma interferon responses in lethal and nonlethal murine blood-stage malaria[J]. Infect Immun,1997,65(5):1593-1598.
[17] KOBAYASHI F,ISHIDA H,MATSUI T,et al. Effects of in vivo administration of anti-IL-10 or anti-IFN-gamma monoclonal antibody on the host defense mechanism against Plasmodium yoelii yoelii infection[J]. J Vet Med Sci,2000,62(6):583-587.
[18] GETIE S,WONDIMENEH Y,GETNET G,et al. Prevalence and clinical correlates of Schistosoma mansoni co-infection among malaria infected patients,Northwest Ethiopia[J]. BMC Res Notes,2015,8(1):480. DOI:10.1186/s13104-015-1468-2.
[19] HOFFMANN KF,CHEEVER AW,WYNN TA. IL-10 and the dangers of immune polarization:excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis[J]. J Immunol,2000,164(12):6406-6416.
[20] MACDONALD AS,ARAUJO MI,PEARCE EJ. Immunology of parasitic helminth infections[J]. Infect Immun,2002,70(2):427-433.
[21] WAKNINE-GRINBERG JH,GOLD D,OHAYON A,et al. Schistosoma mansoni infection reduces the incidence of murine cerebral malaria[J]. Malar J,2010,9(1):5. DOI:10.1186/1475-2875-9-5.
[22] YOSHIDA A,MARUYAMA H,KUMAGAI T,et al. Schistosoma mansoni infection cancels the susceptibility to Plasmodium chabaudi through induction of type 1 immune responses in A/J mice[J]. Inter Immunol,2000,12(8):1117.
[23] BAZZONE LE,SMITH PM,RUTITZKY LI,et al. Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis[J]. Infect Immun,2008,76(11):5164. DOI:10.1128/IAI.00673-08.
[24] SANGWEME D,SHIFF C,KUMAR N. Plasmodium yoelii:adverse outcome of non-lethal P. yoelii malaria during co-infection with Schistosoma mansoni in BALB/c mouse model[J]. Exper Parasitol,2009,122(3):254. DOI:10.1016/j.exppara.2009.04.003.
[25] LEWINSOHN R. Anaemia in mice with concomitant Schistosoma mansoni and Plasmodium berghei yoelii infection[J]. Trans R Soc Trop Med Hyg,1975,69(1):51-56.
[26] THAWANI N,TAM M,BELLEMARE MJ,et al. Plasmodium products contribute to severe malarial anemia by inhibiting erythropoietin-induced proliferation of erythroid precursors[J]. J Infect Dis,2014,209(1):140-149. DOI:10.1093/infdis/jit417.
[27] MBOERA LE,SENKORO KP,RUMISHA SF et al. Plasmodium falciparum and helminth coinfections among schoolchildren in relation to agro-ecosystems in Mvomero district,Tanzania[J]. Acta Trop,2011,120(1/2):95-102. DOI:10.1016/j.actatropica.2011.06.007.
[28] LWIN M,LAST C,TARGETT GA,et al. Infection of mice concurrently with Schistosoma mansoni and rodent malarias:contrasting effects of patent S. mansoni infections on Plasmodium chabaudi,P. yoelii and P. berghei[J]. Ann Trop Med Parasitol,1982,76(3):265.
[29] ANSARI MT,SAIFY ZS,SULTANA N,et al. Malaria and artemisinin derivatives:an updated review[J]. Mini Rev Med Chem,2013,13(13):1879-1902. DOI:10.2174/13895575113136660097.
[30] WANG ML,CAO YM,LUO EJ,et al. Pre-existing Schistosoma japonicum infection alters the immune response to Plasmodium berghei infection in C57BL/6 mice[J]. Malaria J,2013,12(1):322. DOI:10.1186/1475-2875-12-322.
[31] BUCHER K,DIETZ K,LACKNER P,et al. Schistosoma co-infection protects against brain pathology but does not prevent severe disease and death in a murine model of cerebral malaria[J]. Int J Parasitol,2011,41(1):21.
[32] PEARCE EJ,MACDONALD AS. The immunobiology of schistosomiasis[J]. Nat Rev Immunol,2002,2(7):499-511. DOI:10.1016/j.ijpara.2010.06.008.
[33] HELMBY H,KULLBERG M,TROYEBLOMBERG M. Altered immune responses in mice with concomitant Schistosoma mansoni and Plasmodium chabaudi infections[J]. Infect Immun,1998,66(11):5167.
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