中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (12): 1057-1062.doi: 10.12007/j.issn.0258-4646.2018.12.001

• 论著 •    下一篇

中国东北地区人群饮用绿茶与结直肠癌发病关系的病例对照研究

吴鑫1, 石晶1, 李智1, 李贺明2, 曲秀娟1, 刘云鹏1, 张凌云1   

  1. 1. 中国医科大学附属第一医院肿瘤内科, 沈阳 110001;
    2. 大连大学附属中山医院肿瘤科, 辽宁 大连 116001
  • 收稿日期:2018-04-02 出版日期:2018-12-06 发布日期:2018-12-06
  • 通讯作者: 张凌云 E-mail:lyzhang@cmu.edu.cn
  • 作者简介:吴鑫(1992-),女,医师,硕士研究生.
  • 基金资助:
    国家自然科学基金(81372546);辽宁省中央引导地方科技发展专项资金(2016007010);沈阳市重点科技研发计划(17-230-9-01);辽宁省“百千万人才工程”项目(2014921032)

Green Tea Consumption and Colorectal Cancer Risk: a Case-Control Study in Northeast China

WU Xin1, SHI Jing1, LI zhi1, LI Heming2, QU Xiujuan1, LIU Yunpeng1, ZHANG Lingyun1   

  1. 1. Department of Medical Oncology, The First Hospital, China Medical University, Shenyang 110001, China;
    2. Department of Medical Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China
  • Received:2018-04-02 Online:2018-12-06 Published:2018-12-06

摘要: 目的 探讨饮用绿茶与结直肠癌(CRC)发病的关系。方法 采用病例对照研究,收集2009年6月至2011年11月在中国医科大学附属第一医院确诊的新发CRC病例763例,及同期内经年龄、性别及居住地区1:1匹配的体检人员763例。应用非条件logistic回归计算饮绿茶及相关变量与CRC发病风险的调整OR值及95%CI结果 饮绿茶可降低结直肠癌的发病风险(aOR=0.40,95%CI:0.30~0.52)。饮茶杯数的增加、饮茶年限的延长、干茶叶消费量的增多均与CRC的发病风险降低有关(P < 0.05)。饮茶>1杯/d者,CRC发病风险降低65%(aOR=0.35,95%CI:0.23~0.52);饮绿茶年限1~10年与干茶叶消费量500~1 000 g/年者,CRC发病风险分别降低61%(aOR=0.39,95%CI:0.28~0.55)和71%(aOR=0.29,95%CI:0.18~0.49)。发病部位和性别的亚组分析表明,饮绿茶可以降低近端结肠癌、远端结肠癌、直肠癌的发病风险,并降低男性、女性CRC的发病风险。结论 饮绿茶是CRC发病的保护因素。

关键词: 绿茶, 结直肠癌, 病例对照研究

Abstract: Objective To evaluate the association between green tea consumption and colorectal cancer (CRC) risk in northeast China. Methods This was a matched case-control study involving 763 patients with CRC that had been confirmed by pathological diagnosis,as well as 763 healthy controls that were matched in terms of age frequency,sex and location. All participants were recruited at the China Medical University 1st Hospital between June 2009 and November 2011. Unconditional logistic regression was used to calculate adjusted odds ratios (aORs) and corresponding 95% confidence intervals (CI) to assess the association between green tea consumption and CRC. Results Green tea consumption was associated with a decreased risk of CRC. Moreover,greater daily quantity,longer duration of tea drinking,and greater consumption of dry tea were all related to decreased risk (P < 0.05). In participants who drank more than one cup of green tea per day,the risk of CRC was reduced by 65% (aOR=0.35,95% CI:0.23-0.52). In those who drank green tea for 1 to 10 years,the risk of CRC was reduced by 61% (aOR=0.39,95% CI:0.28-0.55),while in those who consumed 500 to 1 000 g of dry tea per year,it was reduced by 71% (aOR=0.29,95% CI:0.18-0.49). When CRC was stratified in terms of subsite,green tea drinking was inversely associated with the risk of proximal colon cancer,distal colon cancer,and rectal cancer. When the participants were stratified by sex,green tea consumption was found to reduce CRC risk in both men and women. Conclusion Green tea drinking is protective against CRC.

Key words: green tea, colorectal cancer, case-control study

中图分类号: 

  • R735
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