中国医科大学学报

中国医科大学学报
  • 中文核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
  • BA、CA收录

中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (12): 1107-1110,1115.doi: 10.12007/j.issn.0258-4646.2018.12.012

• 论著 • 上一篇    下一篇

1 757例住院类风湿关节炎患者临床特点分析

赵滢, 王晓非   

  1. 中国医科大学附属盛京医院风湿免疫科, 沈阳 110004
  • 收稿日期:2018-05-10 出版日期:2018-12-06 发布日期:2018-12-06
  • 通讯作者: 王晓非 E-mail:wangxf@sj-hospital.org
  • 作者简介:赵滢(1990-),女,硕士研究生.
  • 基金资助:
    辽宁省科学技术计划(2014225017)

Clinical Characteristics of 1 757 Hospitalized Patients with Rheumatoid Arthritis

ZHAO Ying, WANG Xiaofei   

  1. Department of Rheumatology and Immunology, Shengjing Hospital, China Medical University, Shenyang 110004, China
  • Received:2018-05-10 Online:2018-12-06 Published:2018-12-06

摘要: 目的 探讨类风湿关节炎(RA)患者的临床特点。方法 回顾性分析2015年1月至2016年12月于中国医科大学附属盛京医院风湿免疫科住院的1 757例RA患者的临床资料,并根据RA疾病活动评分(DAS28)规则对患者的病情活动度进行评分,将DAS28<2.6分计为病情稳定组,DAS28 ≥ 3.2计为病情活动组,对其临床表现及实验室检验指标等进行分析。结果 在规律治疗且检查指标完善的复诊患者中,病情活动期患者占77.2%,病情稳定期患者占22.8%。比较2组患者的血清白蛋白、胆固醇、高密度脂蛋白(HDL)、血小板(PLT)、D-二聚体、血沉(ESR)、C反应蛋白(CRP)水平及生活环境、病程长短,差异有统计学意义(P < 0.05)。logistic回归结果显示,生活环境、病程、ESR及CRP升高是患者疾病复发及病情活动的危险因素。结论 提高对RA的认识,通过完善系统化验及检查,做到早诊断、早治疗,可以改善患者的关节功能,提高生活质量,从而改善疾病预后。

关键词: 类风湿关节炎, 临床特点, 回顾性分析

Abstract: Objective To investigate the clinical characteristics of rheumatoid arthritis (RA). Methods The clinical manifestation and laboratory test records of 1 757 patients with RA who were treated in the Department of Rheumatology and Immunology at Shengjing Hospital of China Medical University from January 2015 to December 2016 were retrospectively analyzed. The enrolled patients were divided according to the disease activity score in 28 joints (DAS28) into stable (DAS28 <2.6) and active (DAS28 ≥ 3.2) groups. Results Levels of albumin (ALB),total cholesterol (TC),high-density lipoprotein (HDL),platelet (PLT),D-dimer (D-D),rheumatoid factor (RF),and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were significantly different between the two groups (P < 0.05) in patients who were regularly treated and had perfect indexes,including 77.2% in the active group and 22.8% in the stable group. Moreover,ESR,CRP level,living environment,and disease course were also statistically different between the groups (P < 0.05). Further logistic analysis revealed that living environment,disease course,increased ESR,and increased CRP level were the risk factors for disease recurrence and activity. Conclusion Raising the awareness on RA and achieving an early diagnosis and treatment using system testing and examination can improve patients' joint function and quality of life and further improve the disease prognosis.

Key words: rheumatoid arthritis, clinical characteristics, retrospective analysis

中图分类号: 

  • R593.22
[1] WANG QT,MA YK,LIU DD,et al. The roles of B cells and their interactions with fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis[J]. Int Arch Allergy Imm,2013,155(3):205-211. DOI:10.1159/000321185.
[2] ESSOUMA M,NOUBIAP JJN. Is air pollution a risk factor for rheumatoid arthritis?[J]. J Inflamm (Lond),2015,12(48):7-10. DOI:10.1186/s12950-015-0092-1.
[3] DESSEIN PH,JOFFE BI. Insulin resistance and impaired beta cell function in rheumatoid arthritis[J]. Arthritis Rheum,2016,54(9):2765-2775. DOI:10.1002/art.22053.
[4] CARPENTIER Y,SCRUEL O. Changes in the concentration and composition of plasma lipoproteins during the acute phase response[J]. Curr Opin Clin Nutr Metab Care,2012,5(2):153-158.
[5] GILES J,LING S,FERRUCCI L,et al. Abnormal body composition phenotypes in older rheumatoid arthritis patients:association with disease characteristics and pharmacotherapies[J]. Arthritis Rheum,2008,59(6):807-815. DOI:10.1002/art.23719.
[6] CHOY E. Understanding the dynamics:pathways involved in the pathogenesis of rheumatoid arthritis[J]. Rheumatology (Oxford),2012,51(5):v3-v11. DOI:10.1093/rheumatology/kes113.
[7] DESHMUKH HA,MAITI AK,KIM-HOWARD XR,et al. Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population:evidence for replication and gene-gene interaction[J]. J Rheumatol,2011,38(9):1866-1870. DOI:10.3899/jrheum.110199.
[8] LAZFROVE I,JOCHMANOVD I,BENHATCHI K,et a1.Autoimmune thyroid disease and rheumatoid arthritis:relationship and the role of genetics[J]. Immunol Res,2014,60(2/3):193-200. DOI:10.1007/s12026-014-8598-9.
[9] CHABCHOUB G,UZ E,MAALEJ A,et a1.Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases[J]. Arthritis Res Ther,2009,11(4):R106. DOI:10.1186/ar2759.
[10] 高志芬,张爽,陈晓玲. 类风湿关节炎病情活动相关实验室指标的测定与分析[J]. 检验医学与临床,2012,9(19):2457-2458. DOI:10.3969/j.issn.1672-9455.2012.19.030.
[11] 孙建,王方明,朱笑夏,等. 河南漯河地区中老年人群类风湿关节炎危险因素调查[J]. 中华老年医学杂志,2017,46(6):802-804. DOI:10.3969/J.issn.1671-8348.2017.06.026.
[12] GORIN AA,SMYTH JM,WEISBERG JN,et a1.Rheumatoid arthritis patients show weather sensitivity in daily life,but the relationship is not clinically significant[J]. Pain,1999,81(1/2):173-177.
[13] IANNACCONE CK,FOSSEL A,TSAO H,et al. Factors associated with attrition in a longitudinal rheumatoid arthritis registry[J]. Arthritis Care Res (Hoboken),2013,65(7):1183-1189. DOI:10.1002/acr.21940.
[1] 方芳, 丁爽, 吴春玲, 段宏梅, 刘海娜, 肖卫国. Noggin阻断BMP-7/Smad信号通路对类风湿关节炎成纤维样滑膜细胞增殖及IL-6、IL-8表达的影响[J]. 中国医科大学学报, 2018, 47(9): 816-819.
[2] 姜文娟, 刘文静, 李晓曦, 沈雪莉. 1例急性原发性胼胝体变性病例的回顾分析[J]. 中国医科大学学报, 2018, 47(7): 657-659.
[3] 范晓蕾, 刘中华, 岳涛, 何东仪. 血清TNF-α、IL-1β、IL-6和IL-17表达水平在阿达木单抗治疗活动性类风湿关节炎中的疗效预测作用[J]. 中国医科大学学报, 2018, 47(6): 556-561.
[4] 于婷婷, 张宁. 类风湿关节炎患者甲状腺相关抗体的临床分析[J]. 中国医科大学学报, 2018, 47(1): 32-35.
[5] 胡巍娜,周东晖,王琦,金元哲. 不同年龄段急性冠状动脉综合征患者临床及冠状动脉造影特点分析[J]. 中国医科大学学报, 2017, 46(6): 566-568.
[6] 赵志国 ,孙寒雪 ,张力平. 76例头颈部淋巴瘤的临床病理回顾性分析[J]. 中国医科大学学报, 2017, 46(1): 75-77.
[7] 丁宁,田霞,孟晨鑫,马玉梅,张明香. 辽宁、黑龙江省1 342例婴幼儿与成人麻疹临床特征分析[J]. 中国医科大学学报, 2016, 45(3): 214-217.
[8] 赵琳,徐京京,王晓非,张晓莉. 类风湿关节炎合并牙周疾病患者的 IL-17A 表达[J]. 中国医科大学学报, 2016, 45(12): 1115-1118.
[9] 刘文静,张惠敏,姜文娟,李晓曦,周志可,沈雪莉. 1 例原发性血小板减少性紫癜合并急性脑梗死病例的回顾分析[J]. 中国医科大学学报, 2016, 45(10): 942-944.
[10] 宋颖,高薇,刘义. 抗骨桥蛋白抗体对胶原诱导大鼠类风湿关节炎作用的研究[J]. 中国医科大学学报, 2015, 44(5): 405-410.
[11] 教婷,张宁. 类风湿关节炎患者血清C-X-C配体10与疾病的相关性[J]. 中国医科大学学报, 2015, 44(11): 992-994.
[12] 宋江美,姜翠清,林栋羚,葛白娟. 7例布鲁菌病合并心内膜炎的临床特征及护理探讨[J]. 中国医科大学学报, 2015, 44(11): 1051-1053.
[13] 崔东源, 王晓非. CCL17在类风湿关节炎患者外周血清中的表达及意义[J]. 中国医科大学学报, 2015, 44(10): 913-916.
[14] 方芳,袁红霞,丁爽,段宏梅,吴春玲,刘海娜,肖卫国. 类风湿关节炎患者血清骨形态发生蛋白7的水平及临床意义[J]. 中国医科大学学报, 2014, 43(9): 814-817.
[15] 胡琰洁,赵丽雅,张颐. 卵巢癌合并皮肌炎2例回顾分析及文献复习[J]. 中国医科大学学报, 2014, 43(4): 363-364.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 尚海,郝志强,傅熙博,华向东,马作红,艾福录,冯照强,王坤,李文心,李博. 中介素通过经典Wnt信号途径促进肝癌细胞增殖[J]. 中国医科大学学报, 2014, 43(7): 631 -634 .
[2] 滕浩, 薛一雪, 王萍, 刘云会. miR-194对人脑胶质瘤U87细胞恶性生物学行为的影响[J]. 中国医科大学学报, 2018, 47(8): 673 -677 .
[3] 盖晴, 冷昶木, 丛树艳. 颅神经受累的吉兰-巴雷谱系疾病35例临床分析[J]. 中国医科大学学报, 2018, 47(9): 769 -772 .
[4] 杜国强, 王立银, 王晓凤, 李君, 张明明, 王瑾. APE1通过NF-κB通路调节PD-L1在喉鳞状细胞癌中的表达[J]. 中国医科大学学报, 2018, 47(10): 865 -870 .
[5] 李羽思, 陈旭. 外泌体调控受体细胞DNA甲基化的研究进展[J]. 中国医科大学学报, 2018, 47(12): 1133 -1136 .
[6] 吴鑫, 石晶, 李智, 李贺明, 曲秀娟, 刘云鹏, 张凌云. 中国东北地区人群饮用绿茶与结直肠癌发病关系的病例对照研究[J]. 中国医科大学学报, 2018, 47(12): 1057 -1062 .
[7] 窦磊, 庞晓燕, 李奇, 尚海, 张颐. 去酰基化ghrelin抑制上皮性卵巢癌细胞的增殖[J]. 中国医科大学学报, 2018, 47(12): 1102 -1106 .
[8] 贡鸣, 何天宇, 裘敬平, 李光. 6种常见肿瘤患者初治时外周血T淋巴细胞亚群数量及临床特征[J]. 中国医科大学学报, 2018, 47(12): 1119 -1122 .
[9] 洪澄英, 陈怀生, 曹静, 杜玉洛, 刘雪燕, 李威. β受体拮抗剂对脓毒症大鼠心肌细胞线粒体损伤的保护作用[J]. 中国医科大学学报, 2018, 47(12): 1123 -1127 .
[10] 呼虹宇, 景治涛, 王运杰. 显微手术治疗侧脑室肿瘤78例临床分析[J]. 中国医科大学学报, 2018, 47(11): 964 -968 .

中国医科大学学报版权所有©2018

未经允许,严禁擅自转载本站图文资料

地址:中国 沈阳市沈北新区蒲河路77号 110122

辽ICP备05014850

JOURNAL OF CHINA MEDICAL UNIVERSITY

ADDRESS: NO.77 PUHE ROAD

SHENYANG NORTH NEW AREA, SHENYANG

LIAONING PROVINCE, P.R. CHINA