中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2018, Vol. 47 ›› Issue (12): 1133-1136.doi: 10.12007/j.issn.0258-4646.2018.12.018

• 综述 • 上一篇    下一篇

外泌体调控受体细胞DNA甲基化的研究进展

李羽思, 陈旭   

  1. 中国医科大学口腔医学院儿童口腔科, 辽宁省口腔疾病重点实验室, 沈阳 110002
  • 收稿日期:2018-07-27 出版日期:2018-12-30 发布日期:2018-12-06
  • 通讯作者: 陈旭 E-mail:chenxu@cmu.edu.cn
  • 作者简介:李羽思(1992-),女,硕士研究生.
  • 基金资助:
    国家自然科学基金(81771059);辽宁省自然科学基金(201602842)

Advances in Exosome Regulation of Recipient Cell DNA Methylation

LI Yusi, CHEN Xu   

  1. Department of Pediatric Dentistry, School of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease, Shenyang 110002, China
  • Received:2018-07-27 Online:2018-12-30 Published:2018-12-06

摘要: DNA甲基化是重要的表观遗传学途径之一,可引起DNA构象、DNA稳定性及DNA与蛋白质相互作用方式等改变,从而影响基因的表达。外泌体是一类由多种细胞分泌,具有双层膜结构的细胞外囊泡,可通过转运相关生物活性因子至受体细胞,参与调控受体细胞DNA甲基化过程,影响受体细胞的生物学功能。本文对外泌体调控受体细胞DNA甲基化的研究进展作一综述。

关键词: 外泌体, DNA甲基化, DNA去甲基化, 受体细胞

Abstract: As one of the earliest epigenetic pathways identified,DNA methylation can change DNA structure,stability,and interaction with proteins to affect gene expression. Exosomes are double-membraned extracellular vesicles secreted by a variety of cells. Some of the bioactive factors released by exosomes into recipient cells can regulate DNA methylation and thus influence their biological function. In this article,we review the advances made in the regulation of DNA methylation by bioactive factors released by exosomes.

Key words: exosome, DNA methylation, DNA demethylation, recipient cell

中图分类号: 

  • R392.2
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