中国医科大学学报

中国医科大学学报
  • 中文核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
  • BA、CA收录

中国医科大学学报 ›› 2019, Vol. 48 ›› Issue (1): 7-11.doi: 10.12007/j.issn.0258-4646.2019.01.002

• 论著 • 上一篇    下一篇

TC1和β-连环蛋白在宫颈癌和癌前病变组织中表达的关系和意义

兰翀1, 聂小毳1, 史玉林1, 徐洪涛2   

  1. 1. 沈阳市妇婴医院妇科, 沈阳 110011;
    2. 中国医科大学基础医学院病理学教研室, 沈阳 110122
  • 收稿日期:2018-04-19 出版日期:2019-01-30 发布日期:2019-01-05
  • 通讯作者: 徐洪涛 E-mail:xuht@cmu.edu.cn
  • 作者简介:兰翀(1977-),女,副主任医师,硕士.
  • 基金资助:
    国家自然科学基金(81372497);辽宁省自然科学基金(20170540833)

Expression of TC1 and β-catenin in Cervical Carcinoma and Precancerous Lesions and Their Significance

LAN Chong1, NIE Xiaocui1, SHI Yulin1, XU Hongtao2   

  1. 1. Department of Gynecology, Shenyang Women and Children's Hospital, Shenyang 110011, China;
    2. Department of Pathology, College of Basic Medical Science, China Medical University, Shenyang 110122, China
  • Received:2018-04-19 Online:2019-01-30 Published:2019-01-05

摘要: 目的 探讨甲状腺癌相关因子1(TC1)和β-连环蛋白(β-catenin)在宫颈癌和癌前病变组织中表达的关系和意义。方法 采用免疫组化方法检测TC1和β-catenin在80例宫颈鳞癌、40例低级别鳞状上皮内病变(LSIL)、40例高级别鳞状上皮内病变(HSIL)和30例宫颈正常组织中的表达情况。结果 TC1在宫颈鳞癌中的表达率显著高于LSIL(P=0.002)和正常宫颈组织(P<0.001),而与HSIL组织相比无统计学差异(P=0.576);TC1的表达与宫颈鳞癌的低分化程度(P=0.005)和高分期(P=0.004)相关。β-catenin在宫颈鳞癌中的异常表达率显著高于LSIL(P<0.001)和正常宫颈组织(P<0.001),而与HSIL组织相比无统计学差异(P=0.907);β-catenin的表达与宫颈鳞癌的低分化程度(P=0.025)和高分期(P=0.001)相关。TC1在宫颈癌前病变(r=0.549,P<0.001)和宫颈鳞癌组织(r=0.249,P=0.008)中的表达均与β-catenin显著相关。结论 TC1和β-catenin在宫颈鳞癌和HSIL组织中的表达显著高于LSIL和正常宫颈组织。TC1在宫颈鳞癌中的表达与β-catenin的异常表达相关,并与宫颈鳞癌的低分化程度和高分期相关。

关键词: 甲状腺癌相关因子1, β-连环蛋白, 宫颈癌, 癌前病变

Abstract: Objective To investigate the expression of thyroid cancer-1 (TC1) and β-catenin in cervical carcinoma and precancerous lesions and their significance. Methods Immunohistochemical methods were used to examine the expression of TC1 and β-catenin in 80 cervical squamous cell carcinoma (CSCC) tissues,40 high-grade squamous intraepithelial lesions (HSIL),40 low-grade squamous intraepithelial lesions (LSIL),and 30 normal cervical tissues. Results Although TC1 expression in CSCC was significantly higher than that in LSIL (P=0.002) and normal cervical tissues (P<0.001),it was similar to that in HSIL (P=0.576). TC1 expression was positively correlated with poor differentiation (P=0.005) and advanced FIGO stage (P=0.004) in CSCC. β-catenin expression in CSCC was significantly higher than that in LSIL (P<0.001) and normal cervical tissues (P<0.001),but was similar to that in HSIL (P=0.907). The abnormal β-catenin expression was also correlated with poor differentiation (P=0.025) and advanced FIGO stage (P=0.001) in CSCC. TC1 expression was positively correlated with the abnormal β-catenin expression in CSCC (r=0.294,P=0.008) and cervical squamous intraepithelial lesions (r=0.549,P<0.001). Conclusion TC1 and β-catenin expression in CSCC and HSIL was significantly higher than that in LSIL and normal cervical tissues. TC1 expression correlated with the abnormal β-catenin expression,and with poor differentiation and advanced FIGO stage of CSCC.

Key words: thyroid cancer-1, β-catenin, cervical carcinoma, precancerous lesion

中图分类号: 

  • R737.33
[1] CHUA EL,YOUNG L,WU WM,et al. Cloning of TC1(C8orf4),a novel gene found to be overexpressed in thyroid cancer[J]. Genomics,2000,69(3):342-347. DOI:10.1006/geno.2000.6348.
[2] JUNG Y,BANG S,CHOI K,et al. TC1(C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby[J]. Cancer Res,2006,66(2):723-728. DOI:10.1158/0008-5472.CAN-05-3124.
[3] WANG YD,BIAN GH,LV XY,et al. TC1(C8orf4) is involved in ERK1/2 pathway-regulated G (1)-to S-phase transition[J]. BMB Rep,2008,41(10):733-738.
[4] YANG ZQ,MOFFA AB,HADDAD R,et al. Transforming properties of TC1 in human breast cancer:interaction with FGFR2 and beta-catenin signaling pathways[J]. Int J Cancer,2007,121(6):1265-1273. DOI:10.1002/ijc.22831.
[5] KIM B,KOO H,YANG S,et al. TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer[J]. Clin Cancer Res,2006,12(11 Pt 1):3541-3548. DOI:10.1158/1078-0432.CCR-05-2440.
[6] ZHANG P,CAO HY,BAI LL,et al. The high expression of TC1(C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue[J]. Tumour Biol,2015,36(9):7061-7067. DOI:10.1007/s13277-015-3423-1.
[7] LEI J,LI W,YANG Y,et al. TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074[J]. PLoS One,2014,9(6):e100075. DOI:10.1371/journal.pone.0100075.
[8] LAN C,NIE XC,YANG LH,et al. Expression of TC1(C8orf4),Atonal homolog 1 and β-catenin is associated with the malignant progression of ovarian carcinomas[J]. Int J Clin Exp Pathol,2016,9(3):3845-3851.
[9] ASHLEY N. Regulation of intestinal cancer stem cells[J]. Cancer Lett,2013,3389(1):120-126. DOI:10.1016/j.canlet.2012.04.016.
[10] CAI C,ZHU X. The Wnt/β-catenin pathway regulates self-renewal of cancer stem-like cells in human gastric cancer[J]. Mol Med Rep,2012,5(5):1191-1196. DOI:10.3892/mmr.2012.802.
[11] LUNDIN A,DRISCOLL B. Lung cancer stem cells:progress and prospects[J]. Cancer Lett,2013,338(1):89-93. DOI:10.1016/j.canlet.2012.08.014.
[12] LIN YW,TSAO CM,YU PN,et al. SOX1 suppresses cell growth and invasion in cervical cancer[J]. Gynecol Oncol,2013,131(1):174-181. DOI:10.1016/j.ygyno.2013.07.111.
[13] UZDENSKY AB,DEMYANENKO SV,BIBOV MY. Signal transduction in human cutaneous melanoma and target drugs[J]. Curr Cancer Drug Targets,2013,13(8):843-866. DOI:10.2174/1568009611313080004.
[14] 乔迪,宋静慧. Wnt/β-catenin信号通路激活与宫颈病变研究新进展[J]. 国际生殖健康/计划生育杂志,2016,35(6):510-514.
[1] 吴思, 吴盈盈, 于淼, 王爽, 崔畅婉, 孙峥嵘. 宫颈组织中Stat5b表达与宫颈病变的关系[J]. 中国医科大学学报, 2019, 48(2): 144-148.
[2] 蒋建发, 邓新粮, 薛敏. 宫颈印戒细胞癌合并透明细胞癌1例报告并文献复习[J]. 中国医科大学学报, 2018, 47(4): 368-370.
[3] 贡鸣, 何天宇, 裘敬平, 李光. 6种常见肿瘤患者初治时外周血T淋巴细胞亚群数量及临床特征[J]. 中国医科大学学报, 2018, 47(12): 1119-1122.
[4] 王敏, 徐翠, 孙静雅, 马桂彦, 郭慧芳. 基于微信的延续护理模式对人乳头瘤病毒感染患者治疗依从性及心理状况的影响[J]. 中国医科大学学报, 2018, 47(11): 1039-1042.
[5] 赵琳,于兆进,何苗,孙明立,魏敏杰. 散发性乳腺癌中 Ezrin 和 β-catenin 蛋白表达的相关性和临床意义[J]. 中国医科大学学报, 2016, 45(8): 673-677.
[6] 张春梅,刘贵鹏,范长友. 宫颈癌术前预置双J管在术后补充放疗前最佳拔管时间的临床研究[J]. 中国医科大学学报, 2016, 45(5): 426-429.
[7] 肖莉,万义增,王宝,李黎. 宫颈上皮内瘤变及鳞癌组织中组蛋白去乙酰化酶1的表达及与HPV16/18感染的关系[J]. 中国医科大学学报, 2015, 44(5): 464-467.
[8] 赵丽雅,庞晓燕,陈青青,孟祥凯,张颐,王化丽. 老年子宫颈高危型HPV感染与子宫颈病变的相关性分析[J]. 中国医科大学学报, 2014, 43(8): 691-693.
[9] 叶郁红,张声,王行富,王密. 宫颈癌相关危险因素分析[J]. 中国医科大学学报, 2014, 43(7): 659-660.
[10] 庞晓奡,张瑶,魏恒,张晶,罗清双,黄成琳,张淑兰. 高迁移率族蛋白1在宫颈癌中的表达及作用[J]. 中国医科大学学报, 2014, 43(12): 1075-1078.
[11] 李朦,刘震,魏力. RUNX3蛋白在宫颈癌中的表达及临床意义[J]. 中国医科大学学报, 2013, 42(9): 812-815.
[12] 张雨芹,李响,王学梅,宛伟娜,李平. 三维能量多普勒对宫颈癌放疗疗效评估的价值[J]. 中国医科大学学报, 2013, 42(9): 836-838.
[13] 穆庆,魏恒,张瑶,罗清双,庞晓奡,张淑兰*. Wnt-11及其受体在宫颈鳞癌中的表达及意义[J]. 中国医科大学学报, 2013, 42(5): 420-424.
[14] 张丹晔,刘娟娟,刘水策,刘冰莹,宫婷婷,林蓓. 妊娠期子宫颈癌22例临床分析[J]. 中国医科大学学报, 2013, 42(2): 175-178.
[15] 张文陆,王言,崔慧霞. 子宫颈癌放疗同步化疗治疗中顺铂用药临床观察[J]. 中国医科大学学报, 2013, 42(12): 1087-1090.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 刘晓默, 张梦琦, 林久祥. 正畸托槽与弓丝间摩擦力性能的实验研究[J]. 中国医科大学学报, 2019, 48(1): 23 -28 .
[2] 张海鑫, 苏琪. 中性粒细胞与淋巴细胞比值在Ⅱ、Ⅲ期中低位直肠癌评估中的临床价值[J]. 中国医科大学学报, 2019, 48(1): 75 -77,84 .
[3] 封宇, 刘颖, 阎雪晶, 欧阳嶷. 双侧颞极白质受累的神经系统遗传疾病12例临床诊断分析[J]. 中国医科大学学报, 2019, 48(1): 90 -93 .
[4] 翟晴, 田阿勇. 富血小板血浆分离应用于体外循环心脏手术的研究进展[J]. 中国医科大学学报, 2019, 48(2): 180 -183 .
[5] 张鑫, 李小寒. 护士循证护理综合能力影响因素分析[J]. 中国医科大学学报, 2019, 48(1): 53 -57 .
[6] 许勇民, 孙大壮, 宋春青, 王蕊, 董雪松. MnTMPyP通过抑制氧化应激和内质网应激减轻百草枯致肺上皮细胞损伤[J]. 中国医科大学学报, 2019, 48(1): 1 -6 .
[7] 兰雨桐, 刘维新, 来爽, 邓秋萍, 杨美琪, 陈轶楠. 小肠结节性淋巴滤泡增生症1例[J]. 中国医科大学学报, 2019, 48(2): 187 -189 .
[8] 冯颜, 潘秋亚, 项阳, 李静. 自身免疫性甲状腺炎血清蛋白质二硫化物异构酶A3抗体的表达[J]. 中国医科大学学报, 2019, 48(1): 12 -16 .
[9] 温行, 李章富, 王辉, 孙绍华, 郭星, 李福才. miR-200c调控肽基脯氨酰顺反异构酶对喉癌Hep-2细胞生物学行为的影响[J]. 中国医科大学学报, 2019, 48(1): 17 -22,28 .
[10] 李思文, 李龙, 李莉. 神经导航系统在经鼻蝶入路垂体瘤手术中的应用及护理体会[J]. 中国医科大学学报, 2019, 48(1): 82 -84 .

中国医科大学学报版权所有©2018

未经允许,严禁擅自转载本站图文资料

地址:中国 沈阳市沈北新区蒲河路77号 110122

辽ICP备05014850

JOURNAL OF CHINA MEDICAL UNIVERSITY

ADDRESS: NO.77 PUHE ROAD

SHENYANG NORTH NEW AREA, SHENYANG

LIAONING PROVINCE, P.R. CHINA