中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2019, Vol. 48 ›› Issue (5): 442-445.doi: 10.12007/j.issn.0258-4646.2019.05.015

• 论著 • 上一篇    下一篇

羟考酮与舒芬太尼用于腹腔镜辅助全子宫切除术术后镇痛的效果比较

李鑫, 吴秀英   

  1. 中国医科大学附属盛京医院麻醉科, 沈阳 110004
  • 收稿日期:2018-03-22 出版日期:2019-05-30 发布日期:2019-05-15
  • 通讯作者: 吴秀英 E-mail:wuxiuying0415@163.com
  • 作者简介:李鑫(1982-),男,主治医师,本科.

Comparison of Oxycodone and Sufentanil for Patient-Controlled Postoperative Analgesia after Laparoscopic Hysterectomy

LI Xin, WU Xiuying   

  1. Deparment of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang 110004, China
  • Received:2018-03-22 Online:2019-05-30 Published:2019-05-15

摘要: 目的对比观察羟考酮和舒芬太尼用于腹腔镜辅助全子宫切除手术术后经静脉自控镇痛(PCIA)的有效性、安全性及患者满意度。方法选择80例患者,随机分为羟考酮(O组)和舒芬太尼(S组)2组,每组40例。术毕前30 min给予0.1 mg/kg羟考酮或0.1 μg/kg舒芬太尼,术毕开启PCIA泵行术后镇痛48 h。于术后2 h(T1)、6 h(T2)、12 h(T3)、24 h(T4)、48 h(T5),行动静态视觉模拟评分(VAS)评分,记录术后48 h内补救镇痛、PCIA实际和无效的按压次数、镇痛满意度以及不良反应情况。结果 O组术后T1~T5动静态VAS均显著低于S组(P<0.05);O组术后实际按压次数及无效按压次数均显著低于S组(P<0.05);2组患者补救镇痛率比较无统计学意义(P>0.05);O组患者满意度显著高于S组(P<0.05)。结论羟考酮用于腹腔镜辅助全子宫切除术术后镇痛较舒芬太尼镇痛效果好,患者术后满意度高。

关键词: 羟考酮, 舒芬太尼, 经静脉自控镇痛, 子宫全切术

Abstract: Objective To observe the efficacy,safety,and satisfaction of intravenously administered oxycodone and sufentanil in patient-controlled postoperative analgesia after laparoscopic hysterectomy. Methods Eighty patients who required patient-controlled postoperative analgesia after laparoscopic hysterectomy were randomly divided into two groups:oxycodone injection(O)group and sufentanil injection(S)group,with forty patients in each group.Both groups received an opioid,oxycodone(0.1 mg/kg)or sufentanil(0.1 μg/kg),30 min before the end of surgery. After the operation,both the groups received patient-controlled intravenous analgesia(PCIA). Pain scores (VAS,visual analogue scale; at rest and when coughing)were recorded at 2 h(T1),6 h(T2),12 h(T3),24 h(T4),48 h(T5)after the end of surgery. Requirement for a rescue analgesic,the number of the unsuccessfully delivered doses,the number of attempts,the level of patient satisfaction,and the incidence of adverse events were recorded within 48 h after operation. Results VAS scores at rest and when coughing from T1 to T5 were significantly lower in group O than in group S(P<0.05). The number of unsuccessfully delivered doses and attempts were also significantly lower in group O than in group S(P<0.05). The level of patient satisfaction was significantly different between the two groups(P<0.05). There was no significant difference in the requirement for rescue analgesic and incidence of adverse events. Conclusion PCIA with oxycodone hydrochloride is more potent than sufentanil after laparoscopic hysterectomy,in addition to yielding higher levels of patient satisfaction.

Key words: oxycodone, sufentanil, patient controlled intravenous analgesia, hysterectomy

中图分类号: 

  • R614.2
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