中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2019, Vol. 48 ›› Issue (7): 638-642.doi: 10.12007/j.issn.0258-4646.2019.07.014

• 论著 • 上一篇    下一篇

术前中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对非肌层浸润性膀胱癌的预后评估价值

高翔, 刘志宇, 王梁, 戴志红, 汪鑫, 蔡凯   

  1. 大连医科大学附属第二医院泌尿外科, 辽宁 大连 116023
  • 收稿日期:2018-02-23 出版日期:2019-07-30 发布日期:2019-07-17
  • 通讯作者: 刘志宇 E-mail:letter89@163.com
  • 作者简介:高翔(1993-),男,硕士研究生.

Prognostic Evaluation Values of Preoperative Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in Non-muscular Invasive Bladder Cancer

GAO Xiang, LIU Zhiyu, WANG Liang, DAI Zhihong, WANG Xin, CAI Kai   

  1. Department of Urinary Surgery, The Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China
  • Received:2018-02-23 Online:2019-07-30 Published:2019-07-17

摘要: 目的 探讨术前中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)对非肌层浸润性膀胱癌(NMIBC)预后评估的影响。方法 回顾分析行经尿道膀胱肿瘤切除术治疗的247例NMIBC患者的临床资料,采用受试者工作特征(ROC)曲线确定NLR和PLR的最佳临界值,采用Kaplan-Meier法进行生存分析,比较患者无复发生存时间(RFS),并采用Cox回归模型确定影响NMIBC患者预后的独立因素。结果 根据ROC曲线,按NLR<2.6(135例)及≥2.6(112例)、PLR<149(120例)及≥149(127例)分组。高NLR组患者的肿瘤分期、肿瘤分化程度与低NLR组差异有统计学意义(P<0.05)。高PLR组患者的肿瘤分期、肿瘤大小与低PLR组差异有统计学意义(P<0.05)。高NLR及PLR组患者的RFS分别较低NLR及PLR组明显缩短。Cox多因素分析结果显示,PLR≥126是NMIBC患者RFS的独立危险因素(P<0.001)。结论 PLR和NLR对于预测NMIBC患者的预后具有较高的应用价值,PLR还是影响患者预后的独立因素。

关键词: 中性粒细胞, 淋巴细胞, 血小板, 非肌层浸润性膀胱癌, 预后

Abstract: Objective To investigate the clinical significance of the preoperative neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)in evaluating the prognosis of patients with non-muscular invasive bladder cancer(NMIBC). Methods A total of 247 patients with NMIBC who underwent surgical treatment were retrospectively analyzed. All the patients underwent transurethral resection of bladder tumor. The receiver-operating characteristic(ROC)curve was used to determine the best critical values of NLR and PLR. The Kaplan-Meier curve method was used to analyze the recurrence-free survival(RFS)of patients. The COX regression model was used to determine the independent factors that affect the prognosis of patients with NMIBC. Results According to the ROC curve analysis,the optimal cut-off points of the NLR and PLR were 2.6 and 149,respectively. Compared with the low NLR group,the difference in tumor stage and differentiation in the high NLR group was statistically significant(P<0.05). The tumor stage and size in the high PLR group were significantly different from those in the low PLR group(P<0.05). The survival analysis showed that RFS in patients with high NLR and PLR was significantly shorter than those in the low NLR and PLR groups. Multivariate COX regression analysis showed that PLR ≥ 126 was an independent risk factor affecting RFS in patients with NMIBC(P<0.001). Conclusion The PLR and NLR have a high value in predicting the prognosis of patients with NMIBC. The PLR can also be an independent factor affecting the prognosis of patients.

Key words: neutrophil, lymphocyte, platelet, non-muscular invasive bladder cancer, prognosis

中图分类号: 

  • R737.14
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