中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2019, Vol. 48 ›› Issue (9): 833-836,851.doi: 10.12007/j.issn.0258-4646.2019.09.014

• 论著 • 上一篇    下一篇

血清sTWEAK和MMP-9在急性ST段抬高型心肌梗死患者中的表达及其与预后的关系

段秋艳1, 杜秋红2, 宋文玲1, 苏嘉利1, 徐萍2   

  1. 1. 沈阳医学院 研究生院, 沈阳 110034, 沈阳 110002;
    2. 沈阳医学院 附属第二医院心内科, 沈阳 110002
  • 收稿日期:2018-10-25 出版日期:2019-09-30 发布日期:2019-09-12
  • 通讯作者: 徐萍 E-mail:xuping61@126.com
  • 作者简介:段秋艳(1990-),女,医师,硕士研究生.
  • 基金资助:
    沈阳市科技计划(F16-206-9-20)

Expression of sTWEAK and MMP-9 and Their Relationship with Prognosis in Acute ST-Segment Elevation Myocardial Infarction

DUAN Qiuyan1, DU Qiuhong2, SONG Wenling1, SU Jiali1, XU Ping2   

  1. 1. Graduate School, Shenyang Medical College, Shenyang 110034, China;
    2. Department of Cardiology, The Second Affiliated Hospital, Shenyang Medical College, Shenyang 110002, China
  • Received:2018-10-25 Online:2019-09-30 Published:2019-09-12

摘要: 目的 探讨血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)和基质金属蛋白酶-9(MMP-9)在急性ST段抬高型心肌梗死(STEMI)患者中的表达及其与预后的关系。方法 收集我院冠状动脉粥样硬化性心脏病患者120例,包括急性STEMI(STEMI组)40例,不稳定性心绞痛(UAP组)40例,稳定性心绞痛(SAP组)40例;收集非冠状动脉粥样硬化性心脏病患者40例作为对照组。采用ELISA检测血清中sTWEAK及MMP-9浓度,并门诊或电话随访出院后3个月主要不良心脏事件(MACE)发生率。结果 STEMI组sTWEAK、MMP-9水平显著高于其他组(P<0.05);UAP组、SAP组及对照组sTWEAK、MMP-9水平的差异无统计学意义(P> 0.05)。sTWEAK、MMP-9可能是STEMI的危险因素(P<0.05);高水平sTWEAK和MMP-9组MACE发生率均高于低水平组(P<0.05)。结论 血清sTWEAK、MMP-9表达水平在STEMI患者中较高,可帮助临床医生判断患者病情的严重程度及预后。

关键词: 血清可溶性肿瘤坏死因子样凋亡弱诱导因子, 基质金属蛋白酶-9, 急性ST段抬高型心肌梗死, 诊断, 预后

Abstract: Objective To investigate the expression of serum soluble tumor necrosis factor-like weak inducer of apoptosis(sTWEAK) and matrix metalloproteinase -9(MMP-9) and their relationship with prognosis in acute ST-segment elevation myocardial infarction(STEMI). Methods The study included 120 patients with coronary heart disease(CHD)in our hospital,including 40 with acute STEMI,40 with unstable angina pectoris(UAP),and 40 with stable angina pectoris(SAP). A control group included 40 patients without CHD. The sTWEAK and MMP-9 levels were measured with an enzyme-linked immunosorbent assay,and the incidence of major adverse cardiac events (MACE)within 3 months after discharge was followed up in the clinic or by telephone. Results The levels of sTWEAK and MMP-9 in the STEMI group were significantly higher than those in the other groups(P<0.05). There was no significant difference in the levels of sTWEAK and MMP-9 between the UAP,SAP,and control groups(P>0.05). The presence of sTWEAK and MMP-9 may be a risk factor for STEMI(P<0.05). The incidence of MACE events in the high-level sTWEAK and MMP-9 groups was higher than in the low-level group(P<0.05). Conclusion Serum sTWEAK and MMP-9 levels are higher in STEMI patients and can help evaluate the severity and prognosis.

Key words: soluble tumor necrosis factor-like weak inducer of apoptosis, matrix metalloproteinase-9, ST-segment elevation myocardial infarction, diagnosis, prognosis

中图分类号: 

  • R541.4
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