中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2009, Vol. 38 ›› Issue (10): 783–.

• 临床医学 • 上一篇    下一篇

胃泌素和生长抑素在糖尿病胃轻瘫中作用的研究

吴波; 杜强; 郑长青; 李倩   

  1. 中国医科大学附属盛京医院内分泌科
  • 出版日期:2009-10-20 发布日期:2010-04-02
  • 通讯作者: 吴波 E-mail:wubo86@163.com

Effects of Gastrin and Somatostatin in Diabetic Gastroparesis

  • Online:2009-10-20 Published:2010-04-02

摘要:

目的探讨胃泌素(GAS)、生长抑素(SS)在糖尿病胃轻瘫(DGP)发生中的作用。方法选患者103例,分为正常对照(CO)组17例、单纯胃轻瘫(GP)组30例、单纯糖尿病(DM)组23例和DGP组33例,应用放免法及RT-PCR方法测定血清中GAS、SS蛋白水平及其组织中mRNA的表达。结果GP组、DM组血清GAS、SS蛋白水平及其组织中mRNA的表达均与CO组存在显著性差异(P<0.05)。GAS及SS在DGP组中的血清蛋白水平及其组织mRNA的表达与CO组比较差异非常显著(P<0.01);与GP组、DM组比较差异显著(P<0.05)。结论GAS的升高、SS的降低是DGP发生、发展的重要因素。

关键词: 糖尿病胃轻瘫, 胃泌素, 生长抑素, 反转录聚合酶链式反应

Abstract:

Objective To investigate the changes of gastrin(GAS)and
      somatostatin(SS)in diabetic gastroparesis(DGP). Methods Totally 103
      patients were divided into normal control group(n =17),simple
      gastroparesis(GP)group(n =30),simple diabetes mellitus(DM) group(n =23)and
      diabetes mellitus complicated with gastroparesis(DGP)group(n =33).
      Radioimmunity and RT-PCR were performed to detect the serum GAS and SS
      levels and the mRNA expression in the gastric mucosa tissue of 4 groups.
      Results There were significant differences in the serum levels and protein
      expression of GAS and SS between simple gastroparesis group,simple
      diabetes mellitus group,DGP group and the normal control group(P < 0.05).
      The differences between DGP group and normal control group was the most
      significant(P < 0.01),the differences between DGP group and the simple
      gastroparesis group or simple diabetes mellitus group were significant (P
      < 0.05). Conlusion The increase of GAS and decrease of SS may play an
      important role in the occurrence and development of DGP.

Key words: diabetic gastroparesis, gastrin, somatostatin, reversed transcript polymerase chain reaction

[1] 张进,李岩. 健脾消食方对脾虚大鼠胃肠运动的影响[J]. 中国医科大学学报, 2015, 44(8): 690-693.
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