中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2009, Vol. 38 ›› Issue (12): 885–.

• 基础医学 • 上一篇    下一篇

不同剂量葛根素在大鼠体内的药代动力学

李煦颖; 张懋璠; 赵妍; 王欣; 孟胜男   

  1. 中国医科大学药学院药剂学教研室
  • 出版日期:2010-01-20 发布日期:2010-04-19
  • 通讯作者: 孟胜男 E-mail:shengnanmeng@yahoo.com.cn

Comparison of Pharmacokinetics between Different Doses of Puerarin in Rats

  • Online:2010-01-20 Published:2010-04-19

摘要:

目的比较不同给药剂量下葛根素在大鼠体内的药代动力学。方法大鼠分别灌胃给予低、中、高剂量(250、500、750mg·kg-1)的葛根素,按实验设计在不同时间点采血,应用高效液相色谱法测定葛根素血药浓度,采用DAS2.0软件计算药动学参数。结果葛根素在大鼠体内药动学过程均符合二室模型;低、中、高3个剂量组的Tmax、MRT均无显著性差异;中剂量组t1/2z与高剂量组、低剂量组均有显著性差异;Vz/F、CLz/F与剂量基本呈线性关系;在250~500mg·kg-1剂量内,AUC与剂量基本呈线性关系,剂量增加至750mg·kg-1时,AUC无明显增加。结论不同给药剂量的葛根素在大鼠体内药动学过程存在差异,给药剂量在250~500mg·kg-1内,葛根素体内药动学行为呈线性关系,给药剂量在500~750mg·kg-1内,葛根素的药动学行为呈非线性关系。

关键词: 葛根素, 药代动力学, 高效液相色谱法, 葛根素, 药代动力学, 高效液相色谱法

Abstract:

Objective To compare the pharmacokineics of Puerarin in rat after
      oral administration of different doses. Methods Rats received 250,500,750
      mg·kg-1 of Puerarin by oral administration respectively. We took blood in
      different time according to the experimental design.The plasma
      concentration of the Puerarin was analyzed by HPLC. The pharmacokinetics
      parameters was calculated with DAS 2.0. Results The pharmacokinetics of
      Puerarin at differernt doses were all best fitted with two-compartment
      models in rats after oral administration. There were no significant
      differences in pharmacokinetic parameter Tmax and MRT among the three
      doses,but Vz/F,CLz/F have sig- nificant differences in the three doses.
      AUC increased with dose rising at 250~500 mg·kg-1,but there was no
      significant increasing at 750 mg·kg-1. Conclusion The pharmacokinetics of
      Puerarin at the three doses were different and showed non-linear
      pharmacokinetics in rats.

Key words: Puerarin, pharmacokinetic, HPLC, Puerarin, Pharmacokinetic, HPLC

[1] 吴越, 周祖华, 闻庆平, 苗壮. 葛根素对大鼠背根神经节神经病理性疼痛的镇痛作用[J]. 中国医科大学学报, 2018, 47(9): 803-806.
[2] 季相禄,田峰,王斌,肖万安. 葛根素治疗急性脊髓缺血再灌注损伤大鼠的神经保护机制[J]. 中国医科大学学报, 2017, 46(4): 313-316.
[3] 张瑛瑛,李季泓. 甘草对高脂血症大鼠模型洛伐他汀药代动力学的影响[J]. 中国医科大学学报, 2017, 46(4): 342-344.
[4] 田峰,王斌,季相禄,田立杰. 葛根素治疗急性脊髓损伤机制的实验研究[J]. 中国医科大学学报, 2013, 42(12): 1126-1129.
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