中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2009, Vol. 38 ›› Issue (9): 674–.

• 基础医学 • 上一篇    下一篇

替米沙坦与非诺贝特对高脂饮食大鼠血清脂联素水平的影响

尹玉; 赵卫华; 胡健   

  1. 中国医科大学附属第一医院心血管内科
  • 出版日期:2009-09-20 发布日期:2010-03-30
  • 通讯作者: 胡健 E-mail:hujian913@medmail.com.cn

Influence of Telmisartan and Fenofibrate on Adiponectin Level in High-fat-fed Rats

  • Online:2009-09-20 Published:2010-03-30

摘要:

目的研究替米沙坦与非诺贝特对高脂饮食大鼠血清脂联素(APN)水平的影响。方法从60只健康雄性Wistar大鼠中随机抽出12只给予普通饲料喂养,其余48只给予高脂饲料喂养。6周后,再将高脂饲料喂养的48只大鼠随机分为4组,每组12只,其中1组继续给予高脂饲料喂养,其余3组在继续给予高脂饲料喂养同时分别给予替米沙坦、非诺贝特和2种药物联合干预。4周后,比较5组大鼠的血清APN水平。结果高脂饮食组大鼠血清APN水平低于普通饮食组;替米沙坦和非诺贝特组均高于高脂饮食组;替米沙坦与非诺贝特联合干预组高于单独用药组。结论替米沙坦与非诺贝特可以改善高脂饮食大鼠血清APN水平,且联合用药效果更明显。

关键词: 替米沙坦, 非诺贝特, 血脂, 葡萄糖钳夹实验, 葡萄糖输注率, 脂联素, 替米沙坦, 非诺贝特, 血脂, 葡萄糖钳夹实验, 葡萄糖输注率, 脂联素

Abstract:

Objective To investigate the effects of telmisartan and fenofibrate
      on adiponectin level in high-fat-Fed rats. Methods Firstly sixty male
      Wistar rats were randomly divided into 2 groups as follow:group A(n
      =12),fed with normal rat food;group B(n =48),fed with high fat food. After
      six weeks feeding,the rats of group B were divided into 4 groups randomly
      (12 rats per group):the rats in group B1 were fed with high fat food
      continually;the rats in group B2 were fed with high fat food and
      telmisartan;the rats in group B3 were fed with high fat food and
      fenofibrate;the rats in group B4 were fed with high fat food and both of
      telmisartan and fenofibrate. Another 4 weeks later, adiponectin level of
      the rats was analyzed. Results The adiponectin level of group B1 rats was
      lower than that of group A;the adiponectin levels of both of group B2 and
      B3 were higher than that of group B1;the adiponectin levels of group B4
      was higher than group B2 and group B3. Conclusion Both telmisartan and
      fenofibrate can improve adiponectin level in high-fat-fed rat,and
      further effect can be achieved in the combined therapy of telmisartan and
      fenofibrate.

Key words: telmisartan, fenofibrate, lipid, glucose clamp test, glucose infusion rate, adiponectin, Telmisartan, Fenofibrate, Lipid, Glucose clamp test, Glucose infusion rate, Adiponectin

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