中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2009, Vol. 38 ›› Issue (9): 687–.

• 临床医学 • 上一篇    下一篇

退行性变腰椎间盘MRI信号强度与aggrecan含量的相关性研究

丛琳; 屠冠军   

  1. 中国医科大学附属第一医院骨科
  • 出版日期:2009-09-20 发布日期:2010-03-30
  • 通讯作者: 屠冠军 E-mail:tu188@sina.com

Correlation between MRI Signal Intensity and Aggrecan Content in Degenerative Lumbar Intervertebral Disc

  • Online:2009-09-20 Published:2010-03-30

摘要:

目的探讨退行性变腰椎间盘MRI信号强度和聚集蛋白聚糖(aggrecan)含量之间的相关性。方法依据Minnatertti分类法分类的46个腰椎间盘样本取自2007年9月至2008年12月在中国医科大学附属第一医院骨科手术的46例患者(年龄14~51岁,平均35岁)。术前测量椎间盘与脑脊液矢状面MRIT2WI平均信号强度比值;术后经Western
      blot测量椎间盘的aggrecan含量。Pearson相关检验分析二者相关性。结果Ⅰ、Ⅱ、Ⅲ类腰椎间盘的平均信号强度比值与aggrecan含量的相关系数分别为0.877,0.689,0.699(PⅠ=0.00426,PⅡ=0.00156,PⅢ=0.0006)。结论退行性变腰椎间盘MRIT2WI信号强度随aggrecan含量的减少而降低,二者之间有明显的相关性。

关键词: 椎间盘退变, 磁共振成像, MRI信号强度, 聚集蛋白聚糖

Abstract:

Objective To investigate the correlation between the magnetic
      resonance imaging(MRI)signal intensity and Aggrecan content in the
      degenerative lumbar intervertebral disc. Methods Forty-six lumbar
      intervertebral disc samples were selected from 46 hospitalized patients
      (age 14~51 years,average 35 years )with lumbar intervertebral disc
      herniation or trauma of lumbar vertebra undergoing surgery procedure. The
      signal values of MRI T2WI of disc and cerebrospinal fluid in sagittal
      plane were measured before operation and the ratio between them were
      calculated. The protein was extracted from the disc,and the Aggrecan
      content was determined by Western blot. The correlation between the signal
      intensity of MRI T2WI and the Aggrecan content was analyzed with Pearson
      test. Results The correlation coefficient(r)between the ratio of the MRI
      signal intensity and the Aggrecan content in the discs of GradeⅠ,Ⅱ and Ⅲ
      were 0.877,0.689 and 0.699 respectively(PⅠ=0.00426,PⅡ=0.00156,PⅢ=0.0006).
      Conclusion The signal intensity of MRI T2WI declines with the
      decrease of Aggrecan content in the degenerative lumbar intervertebral
      disc,and the correlation between them is statistically significant.

Key words: intervertebral disc degeneration, nuclear magnetic resonance, MRI signal intensity, aggrecan

[1] 季蓉 ,郝丽 ,张森 ,郑穗生 ,单艳棋. 肾性继发性甲状旁腺功能亢进症患者大脑影像学表现与认知 功能的相关性研究[J]. 中国医科大学学报, 2017, 46(8): 720-723.
[2] 李冠,邹明宇,杨本强,张立波,谢磊. 伴有胼胝体压部可逆性病灶的轻微脑炎/脑病3 例报告[J]. 中国医科大学学报, 2017, 46(3): 278-280.
[3] 佟晶 ,卑贵光 ,李松柏 ,吕贵文 ,金蓉 ,祝静雅 ,葛微. 3 例颅内脱髓鞘假瘤的影像学表现[J]. 中国医科大学学报, 2016, 45(11): 1046-1048.
[4] 刘文源,张立波,邹明宇,吴越,赵传胜,杨本强,张怡. 磁共振磁敏感加权成像对脑梗死患者微出血的诊断价值[J]. 中国医科大学学报, 2014, 43(12): 1131-1133.
[5] 刘文源,张立波,邹明宇,吴越,赵传胜,杨本强,张怡. DWI及SWI联合应用对急性弥漫性轴索损伤的诊断价值[J]. 中国医科大学学报, 2014, 43(11): 1033-1035.
[6] 赵彬,商秀丽 ,何志义,范国光,刘虎. 阿尔茨海默病的静息态fMRI低频振幅研究[J]. 中国医科大学学报, 2012, 41(4): 329-332.
[7] 刘文源,韩红光,曲红,秦海明,杨本强,张立波,赵明光. 磁共振弥散加权成像监测急性脑静脉性血栓形成的实验研究[J]. 中国医科大学学报, 2012, 41(11): 1041-1046.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!

中国医科大学学报版权所有©2018

未经允许,严禁擅自转载本站图文资料

地址:中国 沈阳市沈北新区蒲河路77号 110122

辽ICP备05014850

JOURNAL OF CHINA MEDICAL UNIVERSITY

ADDRESS: NO.77 PUHE ROAD

SHENYANG NORTH NEW AREA, SHENYANG

LIAONING PROVINCE, P.R. CHINA