中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2010, Vol. 39 ›› Issue (1): 31–.

• 护理学 • 上一篇    下一篇

血清乳酸脱氢酶及其同工酶在复治多发性骨髓瘤中的临床意义

  

  1. 中国医科大学附属第一医院血液内科
  • 出版日期:2010-01-20 发布日期:2013-06-07
  • 通讯作者: 李艳 E-mail:liyan2@medmail.com.cn

Clinical Significance of Serum Lactate Dehydrogenase and Its Isoenzymes in the Retreated Patients with Multiple Myeloma

  • Online:2010-01-20 Published:2013-06-07

摘要:

目的研究血清乳酸脱氢酶(LDH)及其同工酶,M,H亚单位值在复治多发性骨髓瘤(MM)中的临床意义。方法收集复治多发性骨髓瘤患者141例随访资料,分析LDH及其同工酶、亚单位与DS分期、ISS分期、肌酐、骨髓浆细胞数,免疫球蛋白,β2微球蛋白等的关系。结果血清总LDH与DS分期、ISS分期均未见显著联系。LDH1百分比与ISS分期呈显著负相关(P<0.01),LDH4百分比与ISS分期呈显著正相关(P<0.05)。骨髓瘤肾病肾功能不全患者LDH值及LDH4绝对值,H亚单位值与肌酐呈显著正相关(P<0.05)。LDH5百分比及绝对值与骨髓浆细胞数呈显著负相关(P<0.01,P<0.05)。结论对于复治复发性骨髓瘤患者,血清LDH同工酶与ISS分期及肾功损害的程度密切相关,LDH同工酶测定比总LDH活性更具有临床价值。

关键词: 乳酸脱氢酶, 同工酶, 多发性骨髓瘤, 乳酸脱氢酶, 同工酶, 多发性骨髓瘤

Abstract:

Objective To investigate the clinical significance of serum lactate
      dehydrogenase (LDH)and its isoenzymes,M or H subunits in the retreated
      patients with multiple myeloma(MM). Methods 141 medical records of
      retreated patients with multiple myeloma were collected,and the
      relationship of LDH and its isoenzymes,subunits with DS staging system,ISS
      staging system,creatinine,bone marrow plasma cell
      percentage,immunoglobulin and microglobin was analyzed. Results Serum
      total LDH activity was not significantly related to DS staging system and
      ISS staging system. LDH1 percentages was negatively correlated with ISS
      staging system(P < 0.01),and LDH4 percentages positively associated with
      ISS staging system (P < 0.05). LDH activity,absolute value of
      LDH1,LDH2,LDH3,LDH4,and H subunits were positively linked to serum
      creatinine in myeloma kidney disease patients with renal inadequacy (P <
      0.05). Both percentage and absolute value of LDH5 were negatively
      correlated with bone marrow plasma cell percentage ( P < 0.01 and P <
      0.05 respectively). Conclusion The detection of serum LDH isoenzyme is
      more valuable than total LDH activity in retreated patients with multiple
      myeloma.

Key words: lactate dehydrogenase, isoenzymes, multiple myeloma, Lactate dehydrogenase, isoenzymes, multiple myeloma

[1] 王金行, 姜繁明, 刘柏新, 宋鉴清, 刘宇思. 轻链表达缺失的IgD型多发性骨髓瘤免疫表型分析[J]. 中国医科大学学报, 2018, 47(7): 577-580.
[2] 于溪 ,张彬彬 ,杨碧洁 ,张哲 ,马铭霞 ,邹佳运 ,赵明芳. 乳酸脱氢酶和神经元特异性烯醇化酶水平与广泛期小细胞肺癌 预后的关系[J]. 中国医科大学学报, 2017, 46(5): 425-428.
[3] 张津京,李艳. 初诊多发性骨髓瘤合并肾功能不全患者的临床特点和疗效分析[J]. 中国医科大学学报, 2016, 45(6): 494-498.
[4] 李迎春,张嵘,王慧涵,杨莹,朱珂,吴斌,姚鲲,廖爱军,杨威,刘卓刚. 沙利度胺联合环磷酰胺和地塞米松治疗复发难治多发性骨髓瘤[J]. 中国医科大学学报, 2013, 42(6): 564-565.
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