中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2010, Vol. 39 ›› Issue (2): 153–.

• 临床医学 • 上一篇    下一篇

系统性红斑狼疮患者血清λ1干扰素的测定及临床意义

方芳; 肖卫国   

  1. 中国医科大学附属第一医院风湿免疫科
  • 出版日期:2010-02-27 发布日期:2013-06-07
  • 通讯作者: 肖卫国 E-mail:XOnet5670@163.com

Serum Levels and Clinical Significance of Interferon-λ1 in Systemic Lupus Erythematosus Patients

  • Online:2010-02-27 Published:2013-06-07

摘要:

目的检测系统性红斑狼疮(SLE)患者血清中λ1干扰素(IFN-λ1)的水平,探讨其水平与SLE其他指标的关系及其在SLE发病中的作用。方法采用ELISA法检测60例SLE患者和20名正常对照者血清IFN-λ1水平,统计分析其与SLE活动指数(SLEDAI)及其他实验室指标的相关性。结果SLE患者血清IFN-λ1水平为(74.2±16.1)pg/ml,其中病情活动组为(75.1±17.3)pg/ml,病情非活动组为(72.5±17.3)pg/ml,均高于正常对照组(70.4±12.6)pg/ml,但差异无统计学意义,且病情活动组高于病情非活动组,差异也无统计学意义。SLE患者中白细胞减少组血清IFN-λ1水平为(80.1±18.1)pg/ml,高于正常对照组,但差异无统计学意义(P=0.052),同时也高于SLE患者中白细胞正常组(70.6±13.7)pg/ml,差异有统计学意义(P=0.024)。血清IFN-λ1与SLEDAI、C3、C4、24h尿蛋白定量等临床指标不相关。结论IFN-λ1可能参与SLE白细胞减少的过程,本研究未证实IFN-λ1水平与疾病活动相关。

关键词: 系统性红斑狼疮, λ1干扰素

Abstract:

Objective To investigate the clinical significance of serum
      interferon-λ1(IFN-λ1)levels in patients with systemic lupus
      erythematosus(SLE).Methods ELISA was used to evaluate the serum level of
      interferon-λ1 in 60 patients with SLE and 20 healthy individuals as normal
      control.SPSS10.0 statistic software was employed to investigate the
      relation between the serum IFN-λ1 level,the laboratory index and SLE
      disease activity index(SLEDAI).Results The serum IFN-λ1 level in SLE
      patients(74.2±16.1 pg/ml)was higher than that of the normal
      controls(70.4±12.6 pg/ml,P =0.339).The serum IFN-λ1 level in SLE patients
      with leucopenia(80.1±18.1 pg/ml)was higher than those of the normal
      contro(lP =0.052)and the SLE patients without leucopenia(70.6±13.7 pg/ml,P
      =0.024).The serum IFN-λ1 level was not correlated with SLEDAI,complements
      C3,C4,24-hour-proteinuria.Conclusion IFN-λ1 may be involved in the
      pathogenesis of leukopenia in SLE and it has not been proved that its
      level was correlated with the disease activity.

Key words: systemic lupus erythematosus, interferon-lambda 1

[1] 陈向华 ,王建吉 ,耿学丽 ,丁萌 ,华正祥. Tim-1 蛋白表达及其基因多态性与系统性红斑狼疮患者 营养功能的相关性[J]. 中国医科大学学报, 2017, 46(7): 623-627.
[2] 孙涛,肖卫国. 33例系统性红斑狼疮患者死亡原因分析[J]. 中国医科大学学报, 2014, 43(9): 850-851.
[3] 徐京京,王晓非. CCN1在系统性红斑狼疮患者血清中变化的研究[J]. 中国医科大学学报, 2013, 42(5): 429-430.
[4] 刘昌妍,王晓非,张晓莉,郭韵, 蒋莉,刘伟霞. 系统性红斑狼疮患者中活化蛋白C抵抗的测定及临床意义[J]. 中国医科大学学报, 2012, 41(4): 354-356.
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