中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2010, Vol. 39 ›› Issue (2): 92–.

• 基础医学 • 上一篇    下一篇

两种方式高强度聚焦超声2次辐照兔肝移植瘤的比较

张奕; 邹建中; 马闻; 邹海蓉; 王雁; 欧霞   

  1. 重庆医科大学生物医学工程系重庆市超声医学工程学重点实验室
  • 出版日期:2010-02-27 发布日期:2013-06-07
  • 通讯作者: 邹建中 E-mail:zoujz@haifu.com.cn

Comparison of Two Ways of Twice Irradiation on Rabbit Liver Tumor Using High Intensity Focused Ultrasound

  • Online:2010-02-27 Published:2013-06-07

摘要:

目的比较高强度聚焦超声(HIFU)2次辐照兔肝VX2移植瘤时,两种时间间隔方式对治疗效应的影响。方法45只荷瘤兔随机分为3组:A组(1次辐照组)进行一次性辐照消融;B、C组(2次辐照组)先进行1次低剂量辐照(不消融),然后B组于第2日辐照消融,C组于第3日辐照消融。结果2次辐照组与1次辐照组的总治疗时间无显著性差异,但每次辐照时间、皮肤红斑发生率及能效因子(EEF)与1次辐照组比较减小(P<0.05);3组消融后肿瘤组织均发生典型的凝固性坏死,并有效控制复发与转移。结论2次辐照能达到一次性消融相同的疗效,虽总治疗时间相当,但每次辐照时间减少,损伤效率提高,并发症减少。其中连续2d2次辐照方式效果最佳,是一种较为安全有效的HIFU治疗方法。

关键词: 高强度聚焦超声, 2次辐照, 损伤效率, 辐照方式

Abstract:

Objective To compare the two ways of twice irradiation on the
      rabbit liver VX2 tumor using high intensity focused
      ultrasound(HIFU).Methods Totally 45 tumor-bearing rabbits were randomly
      divided into 3 groups:group A(one-time irradiation group)received a
      one-time ablation;group B and C(twice irradiation group)firstly received a
      low-dose irradiation(without ablation),then group B received ablation on
      the next day while group C received it 2 days later.Results Compared with
      one-time irradiation group,the total treatment time of twice irradiation
      group was not significantly different,but the time of each irradiation,the
      incidence of skin erythema and the energy efficiency factor(EEF)were
      less,and that of group B were the least.After ablation,the typical
      coagulation necrosis in tumor tissues occurred, and the recurrence and
      metastasis were effectively controlled in all the three groups.Conclusion
      The total treatment time and efficacy of twice irradiation were same as
      one-time ablation,but the time and dose of each irradiation
      significantly decreased,the damage efficiency was enhanced and the
      complications were reduced.The way of continuous two-days twice
      irradiation was the most effective,which would be a safe and effective
      method of HIFU treatment.

Key words: high intensity focused ultrasound, twice irradiation, damage efficiency, the way of irradiation

[1] 银丽,邹建中,伍烽,卜锐,王琦,刘芳. 高强度聚焦超声壳式辐照离体牛肝组织的实验研究[J]. 中国医科大学学报, 2012, 41(11): 986-989.
[2] 闵加艳,邹建中*,郭宇,王冬. 基于小波变换的高强度聚焦超声消融兔VX2乳腺肿瘤声像图纹理分析[J]. 中国医科大学学报, 2012, 41(1): 14-17.
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