中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2012, Vol. 41 ›› Issue (1): 69–72.

• 临床医学 • 上一篇    下一篇

脑血管病患者高Hcy血症发生机制的初步研究

郑伟1,杨智2,安殿梅1, 3,孟冬娅1,胡晓芳1   

  1. (1.沈阳军区总医院检验科,沈阳 110840;2.沈阳市胸科医院检验科,沈阳 110044;3.辽宁医学院研究生院,辽宁锦州 121001)
  • 收稿日期:2012-09-19 修回日期:2012-09-19 出版日期:2012-01-01 发布日期:2012-09-21
  • 通讯作者: 胡晓芳,E-mail: hxf630212@msn.com.
  • 作者简介:郑伟(1976-),男,副主任医师,博士.
  • 基金资助:
    辽宁省科学技术计划课题(2007225004-6);沈阳军区总医院重点基金课题(06Y-Z13).

Preliminary Study on the Mechanism of Hyperhomocysteinemia in Cerebrovascular Disease Patients

ZHENG Wei1, YANG Zhi2, AN Dian-mei1, 3, MENG Dong-ya1, HU Xiao-fang1   

  • Received:2012-09-19 Revised:2012-09-19 Online:2012-01-01 Published:2012-09-21

摘要: 目的 探讨脑血管病患者高同型半胱氨酸(Hcy)血症的发生机制。方法 分别检测脑血管病患者和健康对照者血清Hcy、叶酸和维生素B12水平。应用TaqMan实时PCR技术检测各组MTHFR C677T基因多态性。结果 脑血管病组血清Hcy水平显著高于对照组(P0.05)。结论 高Hcy血症是导致脑血管病发生的危险因素。MTHFR C677T基因突变及低水平的叶酸和维生素B12是引起血清Hcy水平升高的遗传和营养因素。

关键词: 高同型半胱氨酸血症, 脑血管病, 机制, 高同型半胱氨酸血症, 脑血管病, 机制

Abstract: Objective To investigate the mechanism of Hyperhomocysteinemia in cerebrovascular disease patients. Methods Serum Hcy level was measured by enzyme method. Auto chemiluminescence immunoassay (CLIA) was applied for detecting serum folate and vitamin B12 levels in all groups. The gene polymorphism of MTHFR C677T of patients with cerebral infarction (CI), cerebral hemorrhage (CH) and healthy controls were analyzed by a TaqMan real-time PCR technology. Results Serum Hcy levels in cerebrovascular disease group were significantly higher than that of control group (P0.05). Conclusions Hyperhomocysteinemia was a risk factor resulting in occurrence of cerebrovascular diseases. The mutation of MTHFR C677T and low levels of serum folate and VitB12 were genetic and nutritional factors elevating the levels of serum Hcy.

Key words: hyperhomocysteinemia, cerebrovascular diseases, mechanism, hyperhomocysteinemia, cerebrovascular diseases, mechanism

中图分类号: 

  • R743.34
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