中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2012, Vol. 41 ›› Issue (2): 139–142.

• 临床医学 • 上一篇    下一篇

绝经后女性类风湿关节炎患者骨密度与生化免疫指标相关性的研究

田百玲, 刘旭东, 吴春玲, 杨娉婷, 肖卫国   

  1. 中国医科大学附属第一医院风湿免疫科,沈阳 110001
  • 收稿日期:2012-09-20 修回日期:2012-09-20 出版日期:2012-02-20 发布日期:2012-09-21

Correlation of Bone Mineral Density and Biochemico-immunological Markers in Postmenopausal Female Patients with Rheumatoid Arthritis

TIAN Bai-ling; LIU Xu-dong; WU Chun-ling; YANG Ping-ting; XIAO Wei-guo   

  1. Department of Rheumatology, The First Hospital, China Medical University, Shenyang 110001, China
  • Received:2012-09-20 Revised:2012-09-20 Online:2012-02-20 Published:2012-09-21

摘要: 目的 寻找血生化免疫指标中与类风湿关节炎(RA)患者骨密度(BMD)相关的参数。 方法 选择32例绝经后女性RA患者,测定其血沉(ESR)、C-反应蛋白(CRP)、类风湿因子(RF)、纤维蛋白原(Fib)、血小板(PLT)、血红蛋白(HB)、碱性磷酸酶(ALP)、钠(Na+)、钙(Ca2+)、免疫球蛋白(IgG,IgA,IgM)及补体(C3,C4)值;采用双能X射线骨密度检测仪测量患者的腰椎(L1~L4)及髋部BMD。 结果 绝经后女性RA患者腰椎和髋部BMD与年龄呈显著负相关(腰椎r=-0.505,P<0.01;右髋部r=-0.424,P<0.05;左髋部r=-0.487,P<0.01);多元线性回归分析显示髋部BMD与ALP、RF及Na+关系密切,前两者与BMD呈负相关,后者与BMD呈正相关。 结论 绝经后女性RA患者的BMD随年龄增长呈下降趋势,ALP、RF及Na+与髋部BMD关系密切。

关键词: 类风湿关节炎, 骨质疏松, 骨密度, 生化免疫指标

Abstract: Objective To investigate the correlation between the level of serum biochemico-immunological markers and bone mineral density(BMD) in postmenopausal female patients with rheumatoid arthritis (RA). Methods 32 postmenopausal female patients with RA hospitalized in our wards from 2011.6-2011.11 were selected, and erythrocyte sedimentation rate(ESR), C-reactive protein (CRP),rheumatoid factor(RF),fibrinogen(FIB),platelet(PLT),hemoglobin(HbB), serum alkaline phosphatase(serum-ALP),Na+,Ca2+,immunoglobulin(IgG,IgA,IgM) and complement(C3,C4) were determined,and BMD at of the lumbar lumberspine (L1~L4) and hip waswere measured by dual energy X-ray absorptiometry(DEXA). Results Lumber and hip BMD BMD of the lumbar spine and hip in postmenopausal female patients with RA was significantly negatively correlated with age(Lumber r=-0.505,P≤0.01;right hip r=-0.424,P≤0.05;left hip r=-0.487;P≤0.01);Multiple linear regression analysis showed there was a strong linear relation between hip BMD and ALP、RF、Na+ ,.ALP and RF was were negatively correlated with BMD,and Na+ was positively correlated with BMD. Conclusion BMD in postmenopausal female patients with RA wasis decreased with aging,and there wasis a strong correlation between hip BMD and ALP、RF、Na+.

中图分类号: 

  • R593.22
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