中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2012, Vol. 41 ›› Issue (2): 146–150.

• 临床医学 • 上一篇    下一篇

辽宁地区人乳头瘤病毒的感染状态及其高危基因型的分布情况

王诗卓1, 王宁1, 魏恒1, 栾晓梅1, 刘霞1, 吉耀华2, 张淑兰1   

  1. 中国医科大学附属盛京医院 1. 妇产科;2. 病毒室,沈阳 110004
  • 收稿日期:2012-09-20 修回日期:2012-09-20 出版日期:2012-02-20 发布日期:2012-09-21
  • 基金资助:
    国家自然科学基金资助项目(30973191);辽宁省高峰项目(2010696);辽宁省创新团队(2007T180);盛京医院自由研究者项目资助(200806)

The Infection Mode and Common High-risk Genotypes of HPV in Liaoning Province

WANG Shi-zhuo1, WANG Ning1, WEI Heng1, LUAN Xiao-mei1, LIU Xia1, JI Yao-hua2, ZHANG Shu-lan1   

  1. 1. Department of Obstetrics and Gynecology; 2. Department of Virology Laboratory, Shengjing Hospital, China Medical University, Shenyang 110004, China
  • Received:2012-09-20 Revised:2012-09-20 Online:2012-02-20 Published:2012-09-21
  • Contact: 张淑兰 E-mail:zsl0909@sina.com

摘要: 目的 研究辽宁地区人乳头瘤病毒(HPV)的感染状态和其主要高危基因型别的分布情况。方法 应用特异PCR检测辽宁地区24 041名女性HPV DNA及其主要高危型别的分布。结果 辽宁地区女性人群中HPV总感染率为45.6%(95%CI 44.97%~46.23%),其中28.25%(95%CI 27.68%~28.82%)为HPV机会性感染,17.35%(95%CI 16.87%~17.83%)为持续性感染率。持续感染性HPV的主要高危基因型别依次为HPV-16(18.21%,95%CI 17.04%~19.38%)、HPV-58(13.2%,95%CI 12.17%~14.23%)、HPV-18(8.66%,95%CI 7.81%~9.51%)、HPV-52(7.06%,95%CI 6.28%~7.84%)及 HPV-33(6.78%,95% CI 6.02%~7.54%)。结论 在辽宁地区女性人群中主要持续感染HPV-16、HPV-58、HPV-18、HPV-52和HPV-33五种高危基因型别。

关键词: 人乳头瘤病毒, 持续感染, 基因分型, 辽宁地区

Abstract: Objective To investigate the infection mode and the common types of high-risk human papillomavirus (HPV) in Liaoning Province. Methods Specific PCR method was used to test HPV DNA and the HPV genotypes of HPV forin 24041 women in Liaoning province. Results The HPV infection infected rate of HPV in total was 45.6% in Liaoning province (95%CI, 44.97%-46.23%), including 28.25% (95%CI, 27.68%-28.82%) transient infection and 17.35% (95%CI, 16.87%-17.83%) persistent infection. The common persistent high-risk HPV with persistent infections were HPV-16 (18.21%; 95%CI, 17.04%-19.38%), HPV-58 (13.2%; 95%CI, 12.17%-14.23%), HPV-18 (8.66%; 95%CI, 7.81%-9.51%), HPV-52 (7.06%; 95%CI, 6.28%-7.84%) and HPV-33 (6.78%; 95%CI, 6.02%-7.54%). Conclusion The common persistent high-risk HPV with persistent infections were are HPV-16, -58, -18, -52, -33 in Liaoning province.

Key words: HPV, Persistent infection, Genotypes, Liaoning province

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