中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2012, Vol. 41 ›› Issue (4): 329–332.

• 临床医学 • 上一篇    下一篇

阿尔茨海默病的静息态fMRI低频振幅研究

赵彬1,商秀丽1 ,何志义1,范国光2,刘虎2   

  1. (中国医科大学附属第一医院1.神经内科; ;2.放射科,,沈阳 110001)
  • 收稿日期:2012-09-24 修回日期:2012-09-24 出版日期:2012-04-20 发布日期:2012-09-26

Amplitude of Study of Amplitude of Low-frequency Fluctuation Fluctuation in Patients with Alzheimer’s Disease based on Resting-state Functional MRI Based on fMRI

ZHA0 ZHAO Bin1 , SHANG Xiu-li1, HE Zhi-yi1 FAN Guo-guang 2 ,LIU Hu2   

  1. (1. Department of Neuorology, The First Hospital, China Medical University , Shenyang 110001, China; 2. Department of radiologyRadiology, The First Hospital, China Medical University, Shenyang 110001, China)
  • Received:2012-09-24 Revised:2012-09-24 Online:2012-04-20 Published:2012-09-26

摘要: 目的 应用静息态功能磁共振成像(fMRI)低频振幅((ALFF)方法对阿尔茨海默病(AD) 基线脑活动变化进行研究。 方法 利用GE Signa 3.0T MRI对AD患者组和正常对照组(各18例)分别进行静息态fMRI扫描。应用低频振幅(ALFF)统计方法计算并对比2组ALFF改变的脑区。 结果 静息状态下,AD组患者右侧海马(BA28)及海马旁回(BA36)、左额下回(BA47) 、双侧小脑后叶脑区ALFF值较正常对照组增高,差异有统计学意义( P < 0.001, 未校正);AD组患者楔前叶(BA 7)、后扣带回(BA31) 、左侧丘脑ALFF值较正常对照组减少,差异有统计学意义( P < 0 .001, 未校正)。 结论 AD患者静息态下脑功能区ALFF值产生显著变化。

关键词: 阿尔茨海默病, 静息态功能磁共振成像, 低频振幅 

Abstract: Abstract Objective To investigate the baseline brain activity level in patients with Alzheimer’s disease (AD) In the current study,we used a measure of amplitude of by amplitude of low-frequency fluctuation (ALFF) based on resting-state functional MRI (fMRI) to investigate the baseline brain activity level of Alzheimer’s disease. Methods Eeighteen AD patients with AD (AD group) and eighteen compared with age-matched healthy volunteers (control group) were examined bywere examined by resting-state fMRI on GE Signa 3.0T. functional magnetic resonance imaging,ALFF values of the two groups were calculated and compared. Results In AD group, ALFF values in the right hippocampus (BA28), right parahippocampal gyrus (BA36), Broca’s gyrus (BA47) and bilateral posterior lobes of cerebellum were higher than those in control group, with statistically significant differences (P<0.001); ALFF values in precuneus (BA7), posterior cingulate gyrus (BA31) and left thalamus were lower than those in control group, with statistically significant differences (P<0.001). Compared with the controls, we found that patients with AD showed increased ALFF in the right hippocampus, right parahippocampal gyrus ,left inferior frontal cortex, bilateral cerebellum posterior lobe and reduced ALFF primarily in precuneus ,posterior cingulate gyrus,left thalamus. Conclusion This resting-state fMRI study suggests that the alteration brain activity in the ALFF contributes to the understanding of thepathophysiological mechanism of AD patients.

Key words: Alzheimer’s disease, resting-state functional MRI, amplitude of low-frequency fluctuation

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[1]. Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. [J] . Magn Reson Med ,1995,34(4):537–541.
[2].Fransson P . Spontaneous low-frequency BOLD signal fluctuations:An fMRI investigation of the resting-state default mode of brain function hypothesis[J]. [J]Hum Brain Mapp,2005,26(1):15–29.
[3] Zang YF, H e Y, Zhu CZ, et al. Altered baseline brain activity in children with ADHD revealed by resting state functional MRI[J]. [J] Brain Dev, 2007, 29( 2) : 83-91.
[4] Pelled G, Goelman G. different Different physiological MRI noise between cortical layers[J]. [J] Magn ResonMed, 2004, 52(4): 913-916.
[5]. Raich le ME, MacLeod AM, Snyder AZ, et al . A default mode of brain function[J]. [J] Proc Natl Acad Sci U S A , 2001,98( 2) :676-682.
[6] Li SJ, Li Z, Wu G, et al. Alzheimer disease: Evaluation of a functional MRI index as a marker[J]. [J] Radiology ,2002, 225 (1): 253–259.
[7] Sorg C, Riedl V, Muhlau M, et al. Selective changes of resting-state networks in individuals at risk for Alzheimer’s disease[J]. [J] Proc Natl Acad Sci USA ,2007,104 (47):18760–18765.
[8].] Wang Gould RL, Arroyo B, Brown RG, et al. Brain mechanisms of successful compensation during learning in Alzheimer disease. [J] [J] Neurology, 2006, 67(6):1011–1017.
[9] Sjobeck M, Englund E. Alzheimer’s disease and the cerebellum: a morphologic study on neuronal and glial changes[J]. [J] Dement Geriatr Cogn Disord ,2001,12(3): 211–218.
[10]Bas O, Acer N, Mas N, et al. Stereological evaluation of the volume and volumefraction of intracranial structures in magnetic resonance [J]. Ann Anat,2009,191(2):186-195.
[11] Ishii K, Sasaki M, Kitagi H, et al. Reduction of cerebellar glucose metabolism in advanced Alzheimer’s disease[J]. [J] Nucl Med ,1997,38(6):925–928.。
[12] Fransson, P, Marrelec G. The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: evidence from a partial correlation network analysis [J]. [J] Neuroimage,2008,42(3):1178–1184.
[13] Greicius MD, Srivastava G, Reiss AL, et al. Default mode network activity distinguishes Alzheimer’s disease from healthy aging: Evidence from functional MRI[J]. [J] Proc Natl Acad Sci USA,2004,101(13):4637–4642.
[14] Volkow ND, Zhu W, Felder CA, et al. Changes in brain functional homogeneity in subjects with Alzheimer’s disease[J]. [J] Psychiatry Res ,2002,114(1):39–50.
[15] Jong LM ,Hiele VD,Veer M, et al.Strongly reduced volumes of putamen and thalamus in Alzheimer’ s disease;: an MRI study [J] . Brain , 2008,131(12): 3277-3285.
[16] Zhang HY, Wang SJ, XingJ, LiuB,et al. Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer’s disease[J]. [J] Behav Brain Res ,2009,197(1):103–108.
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